ANZCTR search results

This is an observational study, where we will use a catheter pre- and post-coronary procedures to look for damage to the radial artery caused by trans-radial access. The primary hypothesis is that the radial artery sheath protect the radial artery from spasm and radial artery injuries, and looking at the distribution of injuries along the artery before and after the procedure will allow us to investigate this and guide strategies to protect patients (potential surgical candidates) at higher risk of radial artery injury. We will also study demographic data to help identify these patients that are more susceptible to injury.

To create scalable solutions for the growing number of people living with dementia, we developed MATCH. MATCH is an eHealth solution – Music Attuned Technology for Care via eHealth – developed to support care staff to use music intentionally to support care with people with dementia. The MATCH App has been developed for home and professional care (RAC/hospital) settings, and preliminary trials have been conducted in Victoria, South Australia, and Western Australia. MATCHplus integrates the MATCH App with a bespoke agitation detection system via wearable sensors and an AI-based music recommender system. In this study we will recruit across different professional care settings to: a) Assess the feasibility of implementing MATCH in dementia care in different professional aged care settings; b) Understand the impact of using MATCH Strategies during care on their job satisfaction and care outcomes using self-reported data from care staff; c) Collect data via clinical assessment tools to understand the impact of using MATCH Strategies during personal care and in moments of agitation on neuropsychiatric symptoms of dementia; d) Explore the feasibility, acceptability and utility of the MATCH agitation detection and prediction system; e) Explore the feasibility, acceptability and utility of the MATCH music recommender system for suggesting appropriate individualised music; f) Understand care staff experiences of using MATCH Strategies during care using post-trial interviews; and g) Understand nursing (registered nurse/nurse-in-charge) and management perspectives on the acceptability and utility of implementing MATCH in their professional care setting using post-trial interviews.

The administration of furosemide (a diuretic drug designed to increase production of urine) has been shown to predict a critically ill patient's requirement for dialysis (CRRT). This has been termed the frusemide stress test (FST). Critically ill patients often require dialysis in ICU for severe injury to the kidneys. There is a large amount of evidence around when to start, however there is little to guide clinicians on when the optimal time to stop dialysis is. This is important as whilst dialysis may be life saving, once the kidneys have started to recover it can result in harm. We aim to seek the proportion of patients who respond to the FST and identify whether a future randomised trial to aid clinicians in stopping dialysis at an appropriate time is feasible.

Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery. Current diagnostic methods rely on blood tests and urine output, which often detect AKI only after significant kidney damage has occurred. This prospective cohort study will assess whether the urine albumin-to-creatinine ratio (uACR), a simple and inexpensive urine test, can predict AKI earlier. We will enroll 200 adult patients undergoing cardiac surgery at Austin Hospital. Urine samples will be collected at three time points: before surgery, at admission to the intensive care unit, and the following morning. Our hypothesis is that patients with rising uACR after surgery will have a higher risk of developing acute kidney injury. Early identification could allow timely preventive strategies and improve patient outcomes.

The AQUA Pilot Trial is testing whether giving hypotonic fluids (such as 5% glucose or enteral free water) helps critically ill patients with ICU-acquired hypernatraemia (high sodium levels) recover faster compared to usual care. Patients will be randomly assigned to receive either a structured hypotonic fluid protocol or standard treatment to determine which approach leads to quicker sodium normalisation. The study hypothesis is that the protocolised administration of hypotonic fluid will result in a shorter time to normal serum sodium levels (equal or less than 145 mmol/L) compared to usual care. This research aims to help doctors develop better treatment strategies for managing hypernatraemia in intensive care patients, potentially improving outcomes and reducing complications. The trial will also assess safety by monitoring glucose levels, electrolyte balance, and other important clinical measures.

This study aims to test a new way to deliver radiation therapy to people with cancer that has spread to their bones to enhance local control of metastatic lesions while maintaining acceptable toxicity profiles. Who is it for? You may be eligible to join this study if you are aged 18 years and older, are with Pathological diagnosis of a solid tumour, no planned change to main medication on the first day of protocol radiotherapy. You must have a imaging confirmed bone metastases, estimated life expectancy greater than 3 months. Study details All participants who meet the eligibility criteria in this study will be given either: once a day for 5 days over 1 week, or once a day for 10 days over 2 weeks (Monday to Friday, with weekends off unless needed). The treatment includes a standard radiation dose to the affected bone area, along with a more focused, higher-dose boost to the main tumour area using advanced imaging. This boost is designed to better target the cancer while protecting healthy tissue. During and after completion of the treatment participants will be assessed for pain response and patient outcomes using questionnaires, fractures using imaging, and need for reirradiation and salvage surgery to treatment sites through clinical follow-up and medical record review. It is hoped that this research project will help determine if this combined approach is safe, effective, and practical to deliver in routine care to improve pain relief and tumour control while keeping side effects low

People with pulmonary fibrosis (PF) are 70% less active than healthy individuals. Low levels of physical activity increases fatigue and worsens breathlessness and quality of life. Pulmonary rehabilitation is a recommended intervention to improve physical function, breathlessness, and quality of life in people with PF. Finding strategies that prolong the benefits of pulmonary rehabilitation such as improving physical activity are needed. This study will explore whether a physical activity counselling session, combined with using a physical activity tracker can increase physical activity levels and make pulmonary rehabilitation benefits last longer in people with PF.

The aim of this study is to compare the views of the larynx or voice box obtained by two different commonly used laryngoscopes. A laryngoscope is a device designed to visualize a voice box to place a breathing tube into the trachea for airway support and safety during surgery. The two laryngoscopes are a Macintosh laryngoscope and a GlideScope Spectrum DirectView MAC™ video laryngoscope which are both commonly used throughout Australia and internationally in current practice. Video laryngoscopes, such as the GlideScope Spectrum DirectView MAC™, are commonly used for teaching medical professionals how to place breathing tubes. However, there is no evidence to confirm that the view of the voice box obtained with the GlideScope Spectrum DirectView MAC™ is the same as the standard Macintosh laryngoscope and this may have implications for quality of training.

DALE is a prospective, multi-site registry and biorepository, established to facilitate the collection of clinical data and biospecimens with the aim of furthering drug allergy research. Research questions which may be addressed relate to the epidemiology of drug allergy, our mechanistic understanding of the immune response to drugs in allergic patients, predictors of true or false drug allergy, diagnostic methods to identify causative drugs and quality of care in the management of drug allergy and delabelling.

This study aims to capture information regarding the effect of immune checkpoint inhibitor (ICI) treatment for melanoma on reproductive organ function and sex hormone levels. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with melanoma (Stage II, III or IV) and you are planning to receive ICI treatment. Additional criteria will apply dependent upon your biological sex characteristics. Study details All participants who choose to enrol in this study will be asked to complete a series of questionnaires and provide blood at 4 of their scheduled treatment visits. These visits are anticipated to add 30 minutes to the scheduled visit time. Male participants will also be asked to provide semen samples at 2 of their scheduled treatment visits. These visits are anticipated to add an additional 30 minutes to the scheduled visit time. No additional or novel treatments will be offered to participants who choose to enrol in this study, this is an observational study only. It is hoped this research will contribute important information regarding the potential toxic effects of ICI treatment on sexual and reproductive function in patients with melanoma who are receiving ICI treatment.