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Broad Health Condition Cognitive Decline
Specific Health Condition
A randomised control study of metformin in people with mild cognitive impairment and without diabetes mellitus to determine effects on cognitive decline and neuroimaging over 3 years.
Key inclusion criteria
Inclusion Criteria: - overweight or obese (body mass index >25.0 kg/m2, waist: women>80 cm, men>94cm; - Mild cognitive impairment (Mild Neurocognitive Disorder), based on DSM-5 criteria; - Fasting blood glucose <7.0 mmol/L and HbA1c <6.5%; - Able to undertake neurocognitive testing in English. - Not participating in another trial of drugs or lifestyle modification to reduce cognitive decline. Exclusion Criteria: - Life-threatening illnesses to preclude participation in a 3-year study; - Contraindications to the use of metformin (severe heart failure or eGFR <40).
Minimum age60 Years
Maximum age80 Years