ANZCTR search results

The study hypothesis is that implementation of a nursing program in hospital to reduce noise and interruptions overnight will improve patient's sleep. To investigate the effect of a nursing program to reduce noise and operational interruptions (measurement of vital signs, administration of medications) overnight on a cardiorespiratory ward in an Australian tertiary hospital. Observational study before and after implementation of nursing program. 1. Baseline data collection hospital ward- noise levels overnight, patient sleep duration and quality. 2. Data collection hospital ward after implementation of nursing program- noise levels overnight, patient sleep duration and quality.

The AMLM28/A3 study is part of the ADAPT platform trial (ACTRN12623000900617), which is testing new ways to treat acute myeloid leukaemia (AML). The ADAPT trial will enroll patients unfit for intensive chemotherapy and planned to receive Venetoclax and Azacitidine (VEN-AZA) as standard of care. This study is looking at whether ambulatory management for fever related hospitalisation is more effective than the current standard of care. Who is it for? Patients enrolled on the ADAPT platform trial who have achieved a remission of their AML after VEN-AZA treatment and require hospitalisation due to a fever. Study Details. This is a randomised study where patients will be randomised 1:1 to either receive the ambulatory management compared to the standard of care for fever-related hospitalisation in AML patients enrolled in the ALLG ADAPT platform trial. A total of 100 patients will be recruited across Australian sites. This study aims to determine if ambulatory management can reduce the duration of the time spent in the hospital when AML patients are readmitted due to a fever, after responding to treatment VEN-AZA.

This study aims to evaluate whether an online, individualised exercise and physical activity program is practical, feasible and acceptable for females going through menopause. Participants will complete five individual telehealth sessions with an Accredited Exercise Physiologist, including tailored exercise planning and education to support health during this life stage. The study will assess recruitment, retention, and participant satisfaction, as well as explore changes in physical activity, wellbeing, and menopause symptoms. Findings will guide future research and potential integration into routine care.

Effective postoperative pain management is essential for patient recovery, satisfaction, and prevention of complications. Opioid analgesics are routinely used for the management of acute pain following surgery, and pain in practice often has been assessed using unidimensional scales such as the Numeric Rating Scale. The Australian Commission on Safety and Quality in Healthcare has released a Clinical Care Standard for opioid analgesic stewardship in acute pain recommending that clinicians assess a patient’s functional activity using an evidence-based tool before prescribing opioid analgesics, with the Functional Activity Score (FAS) provided as an example. The FAS offers a multidimensional approach by assessing how pain interferes with activity. Despite these recommendations to include functional assessments, evidence supporting the FAS in Australian hospital settings remains limited. Thus, there is a clear need to address this gap by providing data on the utility and impact of the FAS in an Australian hospital population. This trial addresses that gap by assessing whether integrating the FAS into postoperative care reduces opioid use and improves pain related outcomes.

Consuming adequate amounts of vegetables is crucial for children’s growth, development and long-term health. It is associated with longer life expectancy, better mental health, a healthy heart, reduced risk of cancer, obesity and diabetes, improved gut health and stronger immunity. Yet, in 2022, only 3.5% of Australian adolescents met the Australian Dietary Guidelines target for vegetable intake (5.5 daily serves for girls and 6 for boys) . Around 40% consumed one serve or fewer each day, with vegetable consumption lowest in low socioeconomic areas . Clearly, there is an urgent need to improve adolescent vegetable intake. School food services play a significant role in influencing the foods and drinks students are exposed to and consume. This research aims to evaluate the feasibility of the Chef in Schools Plus program as a strategy to increase sales and consumption of vegetables from secondary school canteens. Tailored to individual secondary schools, the program combines previously successful strategies to increase vegetable consumption, including co-design, professional chef support for canteen staff to improve the availability, appearance, taste and price of vegetable dishes, and an associated co-designed promotion program likely focused on environmental sustainability and planetary health. Six secondary schools will be selected from metropolitan (2 pairs, n=4) and regional (1 pair, n=2) areas. One of each pair of schools will be randomly chosen to try the Chef in Schools Plus Program, while the others will continue with their usual lunch options (to compare results). We’ll gather information about school meals for 2 weeks in one term and for 8 weeks in the next term.

In Australia, many cancer survivors live with bothersome vasomotor symptoms (i.e., hot flushes and night sweats) after cancer treatment. These symptoms can affect daily life. Although supportive treatments exist, barriers such as geographical location, limited specialist clinics hinder accessibility. To address this, efficient models of care to improve access to existing healthcare services are necessary. The MySurvivorCare website, an online health tool designed to help cancer survivors manage hot flushes and night sweats after cancer, was developed to address the unmet. Why this study? This study aims to find out whether it is feasible to conduct a large trial of the MySurvivorCare website before it is launched or made publicly available. Who is it for? You may be eligible for this study if you are a breast cancer survivor and are experiencing hot flushes/night sweats. Study details Participants in this study will be, by chance, allocated to use either the MySurvivorCare website or be provided with access to menopause information from the Australasian Menopause Society website. The MySurvivorCare website will provide users with a self-help guide and information to provide to your GP regarding how to manage symptoms according to the current best practice guidelines. The Australasian Menopause Society website provides educational resources on menopause, including how best to manage symptoms. Participants will be followed up for 6 months via questionnaires. It is hoped that this study will assess how acceptable and easy to use the MySurvivorCare website is, and whether it shows early signs of helping women manage their symptoms over time.

This is a Phase 1b, randomized, double-blind, placebo-controlled, dose escalation study of TRX-100 tablets evaluating the safety, pharmacokinetics (PK), and food effect of single ascending doses of TRX-100 in healthy volunteers. Participants will be enrolled in two cohorts evaluating two dose levels. Each cohort will use a two period design to assess the effect of food (fed vs fasted conditions) on the PK of TRX-100. A total of up to 16 healthy volunteers are planned to be enrolled across 2 cohorts.

Only 25% of individuals with an eating disorder receive treatment, and this includes gay men, who are one of the most vulnerable populations for experiencing these debilitating disorders. Our eHealth intervention, SEED, was co-designed with clinicians, researchers, and gay men to treat eating disorder symptoms, and is intended to be a freely available resource that fills the gap between non-evidence-based but freely available psychoeducation on the Internet (e.g., self-help articles) and evidence-based but expensive psychotherapy (e.g., a $220 session with a clinical psychologist). Our study examined whether SEED is effective in reducing eating disorder symptoms, and whether providing personalised recommendations as part of the app improves how effective it is.

A multicentre, randomised parallel group, open superiority trial. 900 patients 65 years old or older admitted to the general medicine ward with a primary presentation of dyspnoea will be allocated in a 1:1 ratio to receive a) usual care or b) usual care and POCUS of the heart, lungs and proximal lower limb veins, performed within 24 hours of ward admission. The main outcome assessed in length of hospital stay. Secondary outcomes include dyspnoea improvement, mortality and major adverse cardiovascular (MACE) measure at day 30 and 1 year

People with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, often become pregnant during their reproductive years, but active disease during pregnancy can increase the risk of complications for both mother and baby. This observational study will assess standard of care investigations (eg. routine blood tests, intestinal ultrasound, fetal scans) and combine with research blood tests (placental biomarkers) and placental assessment using advanced histological imaging to better understand how immune activity in pregnant people with IBD is linked to changes in the placenta as well as how it can impact complications in the mother and the baby. The study aims to identify blood based biomarkers that may help identify high risk pregnancies early. We hypothesise that higher levels of inflammation in pregnant people with active IBD are associated with changes in placental function and subsequently lead to maternal and fetal complications.