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Periodontitis is a chronic infection, which is mainly associated with Gram-negative bacteria. The aim of the systematic periodontal therapy is to reduce the number of periodontal pathogens to avoid a further progression of the disease, thus to avoid further attachment/bone loss. Systematic periodontal therapy involves, after completion of the initial hygiene phase, debridement of the exposed root surfaces by means of scaling and root planning (SRP). However, some periodontal pathogens have shown to be very resistant to the conventional treatment of periodontitis: SRP and/or surgical periodontal therapy. Even the additional use of systemic and/or local antibiotics has not been able to completely eliminate the pathogens or to maintain periodontal health over a longer period of time so far. In recent times a novel approach, the so called Air Polishing (Ap) has been developed for the removal of subgingival biolfim during SPT with the use a fine powder delivered via a commercially available injection abrasive water jet. Due to the small particle sizes of the powder the damage to the root surfaces compared to sonic, piezoelectric ultrasonic and magnetoconstrictive ultrasonics, is considerably lower. The aim of this study is to investigate whether an adjunct use of a recently introduced Erythritol Powder (Ep) could further improve the clinical and/or microbiological parameters in patients with a mild or moderate type of chronic periodontitis who already received initial therapy (SRP) but are still showing probing pocket depths (PPD) of greater than, or equal to 5mm including bleeding on probing (BOP).

This study will evaluate strategies to implement evidence-based guidelines for screening, assessment and management of cancer pain in adult outpatients presenting at oncology and palliative care services. Who is it for? You may be eligible to join this study if you are aged 18 years or above, have been diagnosed with any cancer and are attending a participating cancer centre as an outpatient. Study details All centres will start in the control arm and transition to intervention arm, but the order in which they transition will be allocated randomly (i.e. by chance). The control arm will receive screening for cancer pain with feedback to medical team to inform treatment and care according to local practice. The intervention includes the addition of strategies to implement evidence-based guidelines for screening, assessment and management of cancer pain. Strategies will include: An audit tool to enable centres to monitor how well they are implementing core standards of cancer pain assessment and management; a toolkit for identifying barriers and facilitators to practice change and implementing strategies to overcome these; QStream online health professional education to test and consolidate knowledge of cancer pain assessment and management; patient-held resources to ensure management remains centred on individual patient needs, support patient-health professional communication and coordination and help patients advocate for evidence-based, person-centred care. The study will compare a time before the strategies are introduced with the time when they are being used to see if there is a difference in the probability of a clinically important reduction in pain for patients with moderate-severe pain. It will also test the effects of the strategies on patient quality of life and empowerment, carer experience, and cost-effectiveness of care.

The primary purpose of this study is to evaluate whether acute supplementation with either of two nutraceutical combination formulas (ErgGo Mom and ErgGo POP), relative to placebo, reduces self-rated mental fatigue associated with performing cognitively demanding tasks.

Previous research has shown that pre-sleep cognitive and emotional arousal increases adolescents' bedtime and sleep onset latency and decreases their total sleep time. We will test whether brief intervention can decrease pre-sleep cognitive and emotional arousal, therefore improving sleep. We hypothesis that the constructive worry and mindfulness body scan groups will lower pre-sleep arousal, and therefore improve sleep, over the no treatment group. Perfectionism may also play a role in how effective treatment is, with treatment being less effective at decreasing arousal for adolescents who score higher on a perfectionism scale, and more effective for those who score lower. Perfectionism will therefore be explored as a moderator (not an outcome measure).

Radiographic evaluation using RSA method to measure migration and stability of the Paragon femoral stem over 2 years post-surgery. Functional evaluation using the Oxford Hip Score. Health related quality of life evaluation using the EQ-5D questionnaire.

Otitis externa (swimmers ear) is a frequent problem worldwide, especially in the tropics. The pain and swelling often makes proper topical treatment difficult. This study aims to evaluate the effect of oral corticosteroids (an anti-inflammatory drug) on swimmers ear.

TaylorActive is a physical activity project for Australian adults. This project is investigating the effectiveness of tailored videos in promoting physical activity using the Internet.

The primary purpose of this study on healthy volunteers is to determine the safety and tolerability of oral AD-6626 without and without alcohol administration in normal healthy volunteers and subjects heterozygous (HeZ) for the aldehyde dehydrogenase 2 (ALDH2)*1/*2 genetic variant

Allocation of an analgesia information sheet following tonsillectomy in children. The primary purpose of the study was to find that if allocation of an information sheet improved post operative analgesia in children and to assess if parents were more knowledgeable regarding analgesia

The aim of this project is to decrease the number of infantry trainees being removed from training and placed into SSW due to preventable injuries. These injuries can be partially attributed to intrinsic risk factors such as poor biomechanics, poor footwear/fitness/body awareness, over training, history of prior injury and BMI <20 or >27. Data collection from six training platoons between 7th February 2011 and 12th August 2011 revealed a mean of 26% of trainees per platoon being injured during the course of training. Of these 53% were classified as preventable injuries and 46% of those trainees were removed from training. This represents a significant number of members incurring injuries that may otherwise have been avoided. From this the concept for implementing some injury prevention training and education evolved and a collective decision was made to examine the implementation and effectiveness of such a program. This will be a randomly controlled trial conducted at the Physiotherapy Department, School Of Infantry, Singleton. It will consist of several components: 1. All members in both the control and intervention groups will be given a questionnaire to fill in regarding intrinsic risk factors to injury. BMI will be assessed. 2. The intervention group will receive a one hour theoretical session on intrinsic risk factors for injuries and how to take active steps to avoid injury (ten tips for injury prevention). 3. The intervention group will then receive a one hour small group practical session looking at biomechanics, posture and body awareness. 4. Trainees identified as having significant risk factor (for example pronating feet) will be given an individual assessment and intervention if required. Potential outcomes of the trial include: - Decrease the number of trainees removed from training and placed in SSW due to preventable injuries - Provide the SOI with an injury prevention strategy that is simple and cost effective - Increase throughput of Infantry members - Reduce number of staff required to manage soldier support wing - Decrease costs associated with trainees moved into soldier support wing (medical, physiotherapy, psychology support, staffing for SSW) - If the program is successful it could be utilised within other areas of the ADF - Increasing retention rates - Decreasing rehabilitation costs and TRW burden - Improve morale amongst trainees by improving health outcomes - Data collection may reveal secondary trends.