ANZCTR search results

BACKGROUND Operative treatment (surgery) is currently the standard way of treating displaced fractures of the olecranon. There is some evidence that good results can be achieved by treating these injuries non-operatively (without surgery). A direct comparison of these treatment methods is needed. AIM This study aims to determine if operative fixation (surgery) is superior to non-operative treatment for isolated displaced fractures of the olecranon (elbow tip) in patients presenting with recent fractures who are aged 75 years or older. HYPOTHESIS It is our hypothesis that operative treatment yields superior elbow pain and function after one year, compared to non-operative treatment. PARTICIPANTS Participants will be selected from patients who present to participating hospitals with olecranon fractures that have occurred within the last 2 weeks, who are eligible for the study. They will be randomised to one of the two treatment arms of the study (operative or non-operative treatment). OUTCOMES Participants will be followed for one year, and the function and pain in the elbow, as well as any complications and their X-rays will be compared.

The purpose of this study is to assess how clonidine as an additive to local anaesthetics works when used for abdominal wall pain blocks (transversus abdominis plane blocks) after gynaecological surgery. One hypothesis is that it causes blood vessel constriction and slows the washout of local anaesthetic into the blood stream, therefore leaving it at its site of action for longer. We will assess this by measuring the levels of local anaesthetic in the blood over time. Simultaneously, we will assess the abdominal wall sensation to determine if and by how long clonidine improves the duration of postoperative pain relief in these patients.

A group-based positive mental health and PTSD symptom management program will be implemented into a residential Alcohol and Other Drug treatment facility. Clients will receive education on the causes and effects of trauma, and will be taught trauma symptom management strategies using an Acceptance and Commitment Therapy approach. The aim is to keep clients in treatment and support them with PTSD symptom management strategies until they can access specialist services post treatment. The evaluation of the project will involve a number of formal assessments as well as retention and self-report data.

An observational, questionnaire based study in which the effectiveness of DRG stimulation as a treatment for chronic low back pain will be assessed in patients routinely scheduled for this treatment

The World Health Organisation has highlighted the importance of preventing weight gain in adults who are of healthy weight and women of reproductive age are a key population to target. Overweight and obesity (defined as a body mass index of 25kg/m2 or more) is a significant health problem, associated with many adverse health outcomes. High rates of weight gain during pregnancy increases the risk of becoming overweight, as it may difficult to lose excess weight gained in pregnancy. It is estimated that approximately 60% of women have high degrees of weight gain during pregnancy, which in turn is recognised as a significant risk factor for adverse maternal and infant outcomes during pregnancy and childbirth. Women with high weight gain during pregnancy are at increased risk of developing diabetes and heart disease as they get older and are more likely to retain weight after they give birth increasing the likelihood that they will commence subsequent pregnancies overweight or obese.  High pregnancy weight gain is a well-recognised risk factor for high infant birth weight (also call macrosomia), and is associated with an increased risk of pre-school obesity. This study is a randomised trial; women will be randomly allocated to receive access to dietary advice (including access to a qualified dietitian throughout pregnancy, to help you adopt a healthy diet and lifestyle) or continue to receive standard antenatal care which does not usually include access to lifestyle advice from a dietitian. The aims of the OPTIMISE Randomised Trial are to evaluate the effects of dietary, lifestyle and exercise advice to optimise gestational weight gain on maternal, fetal and infant health outcomes, among pregnant women of normal body mass index.

The primary purpose of the study is to analyze the effects of topical tranexamic acid in total knee arthroplasty and to compare it with intravenous tranexamic acid. The study is based on the hypothesis that toipical/intrarticular tranexamic acid is more not inferior in reducing blood loss in total knee arthroplasty and is safer as compared to intravenous total knee arthroplasty.

This is a 12 month single blinded parallel randomised controlled trial with 3 arms: control (usual care), intervention (multidisciplinary lifestyle support). A 3rd arm comprises intervention + a food supplement . Participants will be randomised into a control or one of the intervention groups testing the effect of a novel versus conventional form of individualised health care targeting diet, exercise and health behaviour. An additional 12 month long term follow-up will be offered to all participants. Consenting participants will attend quarterly visits with a dietitian

The purpose of this study is to see if general exercise and education are helpful for patients who have had pelvic cancer (colorectal cancer, gynaecological cancer, or urological cancer). Who is it for? Patients may be eligible to join this study if they are aged 18 - 85 years, have undergone surgery for stage I – III pelvic cancer, and are able to walk and manage self-care, out of bed more than 50% of waking hours (Eastern Cooperative Oncology Group performance status 0 – 2). Trial details All eligible patients will be invited to join the general exercise and education group 6 weeks after all their surgical and medical treatments are finished. The general multidisciplinary rehabilitation will consist of a group education and exercise program, which will be provided twice weekly for 8 weeks. Each session will last approximately one hour. The education component will include advice about nutrition, exercise, fatigue management, health behavior change, and coping with stress. Information will be delivered by a range of clinicians (physiotherapists, occupational therapists, psychologists, and dieticians). The exercise component will include a general (combined aerobic and resistance) exercise training program supervised by a physiotherapist. All participants will be required to complete some questionnaires and tests (e.g. six-minute walk test, shuttle walk test etc) at the end of the intervention, and at 6, 12, 24 and 60 months from baseline.

A group-randomised controlled trial of a parenting intervention aimed to improve parenting skills in ways that facilitate the development of emotional competence in youth, and emotional communication in the family, thereby improving youth externalising and internalising difficulties.

This study will use and test a memory training program to improve self-care in patients with heart failure. It is hypothesised that this training will improve memory and heart failure self-care and reduce the number of hospital readmissions