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Insulin pumps are increasingly being used to deliver insulin for people with type 1 diabetes. The two main components of insulin pump delivery are firstly "bolus" insulin, used with meals or to correct high glucose levels, and secondly "basal" insulin which provides the background insulin requirements. The rate of basal insulin delivered is adjustable, and may vary according to the time of day, stress, illness or exercise. Basal insulin rate reductions are typically made by patients prior to exercise to account for changing insulin requirements that occur with physical activity. Information regarding the effects of exercise, and exercise-related changes in basal insulin rate, on insulin and glucose levels is essential to guide clinical decision-making. The purpose of this study is to investigate the impact of exercise, preceded by a major reduction in basal insulin delivery, on insulin levels and associated glucose levels.

The cocooning strategy, which was implemented in Australia in 2009, can have a strong protective effect (indirect) against pertussis in infants. To achieve high maternal coverage, understanding maternal attitudes and other potentially influential factors is important. In this study, we examined the influence of baseline attitudes, modifiable factors and health message framing on pertussis booster vaccine uptake among postpartum women in the hospital setting.

The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress synthesis of the omega-6 pro-inflammatory eicosanoids, prostaglandin E2 and leukotriene B4. Meta-analysis of 10 randomised controlled trials (RCTs) in 1995 reported that fish oil supplementation reduced tender joint count and duration of morning stiffness. Meta-analysis in 2007 of 17 RCTs of fish oil in inflammatory joint pain included 14 RA studies and reported a benefit of fish oil for patient assessed pain, morning stiffness, number of painful and/or tender joints and NSAID consumption. Collectively, these studies determined that symptomatic benefits were seen above doses of 2.7g EPA+DHA per day after a delay of 2 to 3 months. There were at least two features common to these RCTs that are problematic for demonstrating the potential for use of fish oil in RA. Firstly, participants had established disease with the average disease duration being 10.2 +/- 5.2 years across all studies. Secondly, DMARD use was not ‘real life’. DMARDs were held constant with the need for change being a withdrawal criterion, or if drug variation was allowed, it was not according to pre-defined rules. This is an investigator-initiated, double-blind RCT with fish oil in recent onset RA with disease duration < 12 months, using a study design which addresses some of the shortcomings of previous RCTs of fish oil in RA. A treatment algorithm for DMARD use that is responsive to disease activity and tolerability / toxicity, according to pre-defined rules, allows the extent of DMARD to be used as an outcome measure.

We intend to assess the effects of negative suggestion / communication styles on the patient's perception of pain and anxiety during subsequent multiple painful procedures (Local anaesthetic injection, IV cannulation and combined spinal epidural insertion). We will compare these outcomes with the effects that positive suggestion / communication styles has on perception of pain and anxiety during subsequent multiple painful procedures (local anaesthetic injection, IV cannulation and epidural insertion). Null hypothesis = negative or positive styles of communication before painful procedures will have no effect on patient's perception of pain and anxiety during subsequent multiple painful procedures.

A nasogastric tube (NGT) may be inserted into the nostril and passed down through the pharynx (throat) to the stomach to feed patients who are unable to swallow or are unable to eat and drink adequate amounts. If a patient starts or continues eating with a NGT in place, clinical experience suggests the presence of a NGT within the pharynx may in fact interfere with swallowing and hinder a patient’s return to oral intake. Changes in swallowing due to NGT presence have been shown in young volunteers, but not investigated in older individuals. With increasing age we get changes to the normal swallow. As a large proportion of patients requiring NGT feeding are elderly it is important to understand what impact, if any, a NGT might have on an ageing swallow. The aims for this study were to determine what effects, if any, fine-bore and/or wide-bore NGTs have on: (1) airway penetration-aspiration, (2) pharyngeal residue, and (3) duration of pharyngeal transit in older healthy adults.

Sedentary behaviours have become a predominant feature of most adults waking hours. Specifically, prolonged sitting time is now understood to have adverse effects on glycaemic control and other health parameters, adversely impacting on those with Type 2 Diabetes (T2D). Physical activity, including structured resistance exercise, is recommended for the treatment and management of T2D. Resistance activities utilise the larger muscle groups, potentially providing a greater stimulus for glucose uptake; however, many people with T2D may be unable or insufficiently motivated to meet these recommendations. Encouraging recent evidence shows that walking breaks throughout the day are an effective strategy to offset the deleterious effects of prolonged uninterrupted sitting in older, overweight adults. However, these experimental findings are yet to be verified in those with T2D – who could derive the greatest benefit. This study will examine the acute effects of a single bout of prolonged sitting on postprandial blood glucose, insulin and lipids with and without intermittent bouts of light-intensity walking or simple resistance activities in adults with T2D. Twenty four inactive and injury free participants aged between 35-75 years with diagnosed T2D (longer than 3 months) who are either diet or Metformin controlled will be recruited. Participants will visit the lab on 5 separate occasions. First, they will attend a 120 minute screening and medical exam, then a 60 minute familiarisation session one week prior to the commencement of the experimental trial. During screening, participants will complete a standard Glycated Haemoglobin (HbA1c) test to verify diabetes status (>=6.5%, but <=9%) and will be assessed on their suitability and safety to participate in the study. Familiarisation will ensure they are comfortable with the equipment and exercises, and suitable technique and movement consistency are achieved. The energy expenditure of the two activity breaks will also be measured a this visit. Participants will then complete three experimental conditions in a random order (each 8 hours duration with an initial 1 hour steady-state period) separated by a minimum 6 day washout period. The experimental conditions are: (A) Uninterrupted sitting (control condition): Participants will sit quietly in a lounge chair for 8 hours, with breakfast and lunch provided during this period; (B) Sitting + light-intensity walking breaks: Following baseline measurements and after sitting quietly for 1 hour (steady state) and allowing for consumption of the breakfast meal (20 minutes), participants will complete a 3 min bout of light-intensity walking on the treadmill (level, firm surface, slow pace – 3.2 km.hr-1). They will then return to the seated position. This procedure will be repeated on a further 11 occasions every 30 min (except where a lunch meal is consumed) for a total of 36 min of light-intensity activity; (C) Sitting + simple resistance activities: Identical procedure to condition B, however, participants will complete a 3 min bout of simple resistance activities. The activities will be allocated into nine 20 second segments, alternating between body weight half-squats, calf raises and brief gluteal contractions in-between single leg knee raises. This interchange between movements will provide rest for the corresponding muscle groups between each activity segment. To ensure appropriate standardisation, participants will complete each activity in a controlled manner within their range of motion (knee/hip 45 to 90° for half-squats/knee raises). Exercise tempo and correct ‘form’ will be achieved by participants mimicking a pre-prepared video recording, with which they have been previously familiarised. Fasting and postprandial blood samples (glucose/lipids, insulin/C-peptide, incretins, catecholamines and full blood examination) will be measured half-hourly throughout each trial, while blood pressure will be collected at each hour time point. Perceived fatigue will be assessed every 2 hours. With high volumes of sitting becoming a growing concern, there are potentially important and practical benefits of breaking up sitting time with brief bouts of light intensity activities. This research will provide insights into whether breaking up sitting time with light intensity walking and simple resistance activities has the potential for health benefits in those with T2D. The results of this study have potential to provide more detailed, practical and potentially prescriptive information to help shape clinical and public health approaches in T2D.

The cardiovascular system is made up of the heart, blood vessels and blood, and is responsible for the delivery of nutrients and removal of waste from the body. Blood flow is primarily regulated by the very small blood vessels. Examination of the skin blood vessels using laser Doppler flowmetry is an easy method that provides an index of global microvasculature function. Statins are a class of drug that reduce cardiovascular events and mortality. In addition to lowering cholesterol levels, statins demonstrate a number of other effects that protect the heart. After a heart attack, statins improve patient outcomes by improving the function of the large and small blood vessels. Rosuvastatin is more potent and effective than other statins. However, no studies have investigated the effect of Rosuvastatin on the very small skin blood vessels in patients who have had a minor heart attack. This pilot study aims to evaluate the effect of 1-week low- vs. high-dose Rosuvastatin therapy on very small blood vessel function in patients who present with a minor heart attack compared to a healthy population. We hypothesise that 1-week high-dose Rosuvastatin in minor heart attack patients and healthy controls does not improve the function of the very small blood vessels when compared to 1-week low-dose Rosuvastatin.

Pharmacists and pharmacy staff frequently deal with customers who have limited ability to understand information about their medicines and health care. This project aims to adjust the services and counselling provided by pharmacists and pharmacy staff to accommodate the needs of people with low levels of health literacy without necessarily detecting health literacy issues. The hypothesis for the study is that Australian pharmacists lack the ability to effectively communication with consumers who have health literacy issues, and are unaware of particular communication techniques to overcome health literacy barriers when interacting with consumers

This experimental study will examine the effectiveness of increasing motivation and self-control to reduce alcohol consumption among undergraduate students..It is proposed that motivation and self-control are two psychological factors that can influence alcohol consumption. Adopting theoretical perspectives from the Pham and Taylor’s (1999) model on mental simulations and the strength model of self-control (Baumeister et al., 1998), people who are motivated via a process mental simulation manipulation and have self-control practice on a Stroop task will be more likely to reduce their alcohol consumption.The aim of this research is to test the hypothesis that individuals who receive motivation and self-control manipulations will have higher reduction in alcohol consumption than a control group comprising individuals that did not receive manipulation. Also, we hypothesise that combined experimental manipulations of motivation and self-control is more effective than either of the motivation and self-control manipulations alone in reducing alcohol consumption

This project aims to encourage healthy eating behaviours in people with mental illness who are residing in a Community Rehabilition Care centre. We will investigate the impact of healthy eating and daily fish oil supplementation on participants' mental and cardiometabolic health over 6 months.