ANZCTR search results

This study :Healthy and Unhealthy Eating Behaviours in Male Gym Users (18-65years)" is aimed at working with male gym users who have low self-esteem, poor body image and unhealthy eating behaviours. It is designed to provide them with education around body image and the influence of the media as well as the signs and sympomts of unhealthy eating behaviours.

Open Label Extension Study to Evaluate the Safety, Tolerability and Cognitive Effects of VEL015 (Sodium Selenate) in Patients with Alzheimer’s Disease

Skin cuts are common injuries sustained by children. There are two main to stitch cuts. The first method is to use stiches on the outside of the skin and the other method is to use a deeper stitch that would not be able to be seen on the skin surface. The purpose of this project is to study whether one of these two methods of stitching results in better healings of cuts. We do not know whether one method of closing facial skin cuts is better than the other. Both methods have their advantages and disadvantages. Stitches under the skin (or buried stitches) provide good support for facial wound closure while stiches on the skin (external stitches) have a lower risk of complications but may result in a more visible scar. Previous research studies on adults have found that the both buried and external stiches have healed in a similar fashion

The hypothesis is that the use of Aquablation will provide a clinically effective cutting and coagulation action on prostatic tissue without the need for thermal energy thereby reducing perioperative complications such as bleeding, catheterisation, shorter recovery time and dysuria. It is hypothesised that the more effective operative technique will provide an earlier improvement in patients' quality of life as evidenced by a reduction in symptoms, no deterioration of erectile dysfunction and improvements in peak urinary flow rate and post void residual volume.

Some adults with cerebral palsy have more difficulty with walking as they get older. Impaired balance and reduced balance confidence have been suggested to be contributing factors to this decline. This project will conduct a small randomised trial to examine the effect of a physiotherapy program of balance training on the walking self-confidence and balance of adults with cerebral palsy, compared to a different program of a variety of meditation, relaxation and lifestyle activities.

The main aim of this study is to compare two products for preventing or reducing the severity of radiation induced dermatitis (RID). RID is a common side effect of radiation therapy. RID is characterised by skin redness and in severe cases, the skin thins and begins to weep and may be susceptible to infection. With ongoing radiation, the skin condition and appearance often worsens. This trial aims to compare sorbolene cream which is the standard product that is recommended for use by patients at the Royal Adelaide Hospital with a lotion containing extract of Calendula officinalis (marigold flower), called Calendula lotion. Calendula is reported to have anti-inflammatory properties and may encourage skin healing. The hypothesis for the study is that Calendula lotion offers significant benefits compared to sorbolene when used for the prevention or treatment of RID. Who is it for? This study is open to women 18 years and over who have undergone prior lumpectomy or mastectomy and are due to undergo post-surgical radiotherapy for breast cancer using standard treatment pathways. Participants will need to provide informed consent, and not be undergoing any concurrent chemotherapy at the time of participation. Full exclusion criteria for this study can be found in the relevant section of this form. Trial details You will be randomised to receive either Calendula officinalis lotion (marigold extract 32%v/v) or Sorbolene lotion with 10% glycerine, which will be topically applied to skin twice a day every day of the week during radiotherapy treatment (typically a 5 week period) and for up tp 6 weeks. Participants will be instructed to apply lotion generously to entire irradiated skin using an amount approximately in size to a 20cent-50cent piece (dependent on physique).

The aim of the study is to identify patients with poor medication-taking behaviour and implement personalised interventions to improve medication-taking behaviour. We hope to learn about changes in medication-taking behaviour over time and to determine the degree to which improvements in this behaviour are sustained. We also want to learn if using the MAQ and Beliefs about Medicines Questionnaire - Specific was helpful to improve medication-taking behaviour. We hypothesise that: - Personalising interventions to patients known to have poor medication-taking behaviour will improve medication-taking behaviour at three months. - Improvements in medication-taking behaviour at three months will not be sustained at six months. - Medication-taking behaviour, and the reasons for poor medication-taking behaviour, will change over time in all groups studied.

This study aims to examine whether extra support from a midwife in early labour, before arrival at hospital, can safely reduce the number of women who give birth by caesarean. Women who agree to take part are allocated by chance to receiving this extra care, or to the usual support provided at the hospital. Once they arrive at hospital, care is provided according to the usual hospital practices.

This study is looking at methods used to intubate (insert a breathing tube that connects to a ventilator) sick infants. The standard method, which has been used internationally for many years, involves the doctor first inserting a laryngoscope into the infant’s mouth. This is an L-shaped device with a light at the tip. When it is manipulated correctly, it moves the infant’s tongue and jaw allowing a view of the infant’s airway. The doctor can then insert the breathing tube through the voice-box into the airway. This is a difficult procedure for doctors to learn and more than one attempt is often required to insert the breathing tube correctly. A more senior supervising doctor is usually present to assist during the procedure but is limited by the fact that he/she cannot see in the infant’s mouth. The devise being examined in this study is a videolaryngoscope. This is structurally the same as a traditional laryngoscope but displays real time images on to a nearby monitor. This essentially means that the assisting doctor can now see what the intubating doctor sees and can therefore potentially offer improved guidance and assistance. This is a randomised controlled trial and any infant at the Royal Women’s Hospital, Melbourne, who requires intubation, is eligible for inclusion. If the infant is very sick and needs urgent intubation, they are excluded. All intubations in the study will be performed by neonatal registrars, who are junior doctors in training. The enrolled infants will be allocated randomly into the intervention group or the control group. In the intervention group, the registrar will attempt to intubate the infant using the videolaryngoscope and standard breathing tubes. A supervising doctor will be present and view the videolaryngoscope screen. They will offer instruction to the registrar based on the images they see. In the control group, the registrar will attempt to intubate using the videolaryngoscope and standard breathing tubes. However this time, the monitor will remain covered during the intubation attempt. The registrar will still be offered verbal guidance, as would be standard current practice. In both groups it will be recorded if the first attempt resulted in correct placement of the breathing tube. The main result of the study will be a comparison of the rate of correct tube placement between the two groups.

Damage to the Anterior cruciate ligament (ACL), a ligament vital for the stability of the knee joint, affects the ability to perform daily activities and physical exercise. The reduced physical activity caused by knee injury can cause changes in the muscle of the leg, causing decreased muscle strength, size and endurance. This study proposes to test the effect of ACL injury (knee injury) on muscle on a microscopic or molecular level, and investigate how such molecular changes in the muscle can affect knee function. A second aim of the study is to investigate the role of inflammation in the knee joint and how it affects leg strength and physical activity levels. This will be achieved by measuring strength, balance, physical activity levels, and muscle samples in patients undergoing ACL reconstructive surgery compared to a matched control group. It is hypothesized that after acute ACL trauma, functional changes in quality of life and muscle function of the injured limb will be associated with adverse changes in knee extensor muscle contractility on a biochemical level.