ANZCTR search results

The purpose of this study is to determine the effect of potassium supplementation in a single meal on blood vessel function. A high potassium intake is associated with reduced risk of heart disease however effect of potassium on blood vessel function is not known. We propose potassium supplementation will improve blood vessel function.

The purpose of this project is to develop a quality of life instrument specific to autoimmune bullous disease. Patients with clinically and histologically diagnose autoimmune bullous disease will be recruited and interviewed regarding the ways their disease affects their quality of life. Based on these responses, a pilot questionnaire will be developed and given to 70 patients. Statistical analysis will then be performed based on the results of these questionnaires to determine whether the instrument is statistically sound or not. If it is validated, the instrument can then be used as a tool to measure quality of life in patients with autoimmune blistering skin diseases.

Obesity in men is one of the greatest public health challenges facing Australia. Obesity is an independent risk factor for cardiovascular disease (CVD) and a major cause of preventable death and disability. With 70% of Australian men overweight or obese, the current and predicted financial and human costs are alarming. Despite men being more susceptible than women to many of the serious consequences of obesity such as CVD, men rarely engage in weight loss (WL) programs, and when they do lose weight they rarely maintain the WL. There is an urgent need to develop and evaluate novel and cost effective approaches that achieve long-term WL in men. The aim of this pilot study is to develop and evaluate the feasibility and efficacy of a WL maintenance (WLM) program specifically for men.

The Dietary Approaches to Stop Hypertension (DASH) diet, which is high in fruit, vegetables and dairy and lower in fats, signficantly reduced blood pressure in people without diabetes. At present their has been no investigation of the effect of the DASH diet in people with diabetes. The aim of this pilot study is to investigate the feasibility of a DASH like diet in people with diabetes

The data in this study offer evidence for the value of Spaced Education Diabetes (SED), a tailored, adaptive, online diabetes education program, in improving evidence-based management of type 2 diabetes, by GPs. Spaced Education Diabetes (SED) is an innovative approach that can be delivered by email and tailored to individual GP knowledge levels. It will deliver education to improve management of hyperglycaemia, hypertensive and hyperlipidaemia. The study aims to improve GP management and control of metabolic targets in type 2 diabetics, and improve patient outcomes.

This study aims to investigate the safety, toxicity and efficacy of a treatment combination of the drugs Iodine-131-Rituximab and Panobinostat in patients with Relapsed and Refractory Indolent B-cell Lymphoma. The trial will be conducted in Melbourne at the Peter MacCallum Cancer Centre and in Fremantle at Fremantle Hospital. Who is it for? To be eligible for this study, you must be aged 18 or above with a histologically confirmed relapsed indolent B-cell non Hodgkin's lymphoma. Further details of the inclusion criteria for this trial can be found in the corresponding section of this trial record. Trial Details There are two phases for this study, with three dose levels of panobinostat considered in phase I of the study, which is the dose finding phase. This will be followed by phase II, which consists of an expanded cohort at the phase I determined dose of panobinostat. In phase I, you will receive oral panobinostat which will be administered at a dose of 20, 30 or 40mg in 5, 15 and 20mg tablets. This will commence on day one on a Monday and will continue to be given on Monday, Wednesday and Friday weekly for four weeks. A tracer activity of 200 MBq131I-rituximab will then be administered intravenously after an intravenous dose of 375 mg/m2 rituximab unlabeled antibody, with both given on day four. Whole-body imaging and background scans will be performed within one hour in the administering department, and be repeated four and seven days later under the same imaging conditions. Full details of the treatment regime can be found in the Description of intervention(s)/ Exposure field of this trial record.

Childhood Apraxia of Speech (CAS) is a motor speech disorder. Children with CAS have difficulties planning the movements required for speech sounds and melody. The difficulties associated with CAS often persist through life and are deterimental to academic, social and vocational development, despite normal intelligence. Currently a number of single case designs are available yet few treatments have been tested or replicated. We intend to complete the first randomised control trial to compare two treatments for CAS. The speech therapy treatments we want to compare are 1) the Rapid Syllable Transition Treatment (Ballard et al, 2010) and 2) the Nuffield Dyspraxia Programme (3rd edition) (Williams & Stephens, 2004). Both treatments have preliminary promising evidence. We want to know if these treatments improve speech sounds and melody in children with CAS age 4-12 years. We also want to know which treatment will make better gains in treated sounds/words/sentences AND untreated but similar sounds/words/sentences.

Physical inactivity is one of the major causes of many chronic preventable diseases such as obesity, diabetes and cardiovascular disease. There is a growing understanding that low energy activity or sedentary behaviour and breaks in sedentary time are also independently linked to cardiometabolic risk factors. Furthermore, in the “technological” age, occupational physical activity has reduced. Currently, it is estimated that office workers spend approximately 75% of their working hours sedentary (sitting) and are therefore at risk of many of the adverse health consequences associated with prolonged sedentary behaviour. Workplace activity intervention programmes have focussed on increasing moderate/vigorous physical activity typically by encouraging walking before and after work or during breaks. To date, there is no research that has examined the effect of modifying office work to incorporate short bouts of light intensity physical activity and encouraging breaks in sedentary behaviour. Aims 1) To assess if a participatory work-based programme to encourage incidental and light intensity physical activity can reduce sedentary time of office workers 2) To assess if a participatory work task focussed intervention to promote reduced sustained sedentary time and increased incidental activity is more effective at reducing sedentary time than interventions focussed on physical activity in discretionary time or an office workstation ergonomics intervention 3) To assess if changes that result from a participatory work-based intervention programme are sustained 3 months following the intervention 4) To determine if there is a relationship between participatory workplace health programmes and musculoskeletal pain and job satisfaction

The aim of this study is to develop, implement and evaluate a practice pharmacist role in primary care practices to improve the quality use of medicines by patients and health professionals. Part-time practice pharmacists will be located in two primary healthcare clinics in Victoria. The pharmacists provide long and short patient consultations, education sessions, drug information services and quality assurance activities. Patients receiving long consultations with a pharmacist will be followed over 6 months. Medication-related problems, medication adherence, health and well-being, and patient satisfaction will be assessed. Patient and staff experiences with the service will also be explored.

The purpose of the study is to evaluate whether Grandparent Triple P is effective in assiting grandparents supporting their grandchildren. Specifically it is hypothesised that compared to a control group, grandparents participating in Grandparent Triple P would have increased parenting self-efficacy; increased relationship satisfaction with biological son or daughter (the parent); decreased reliance on dysfunctional parenting strategies; and decreased levels of depression, stress, and anxiety. Additionally, it was hypothesised that grandparent participation in the intervention would result in positive childhood outcomes, specifically a reduction in childhood behavioural problems. The secondary hypotheses were that grandparents would experience higher marital relationship satisfaction and decreased partner conflict over parenting strategies. It was predicted that these positive treatment outcomes would be maintained at six-month follow-up. Finally, a secondary outcome hypothesized was that parents would report an increase in relationship satisfaction with the grandparents, and that parents would also report a reduction in childhood behavioural problems.