ANZCTR search results

Mechanical bowel preparation causes a marked imbalance in the colonic microflora. This altered microflora may play a significant role in post-preparation symptoms and delay in return of the normal bowel function for that patient. AIM Evaluate the benefit of probiotic use, and associated restoration of the balance of intestinal microflora, for patients undergoing colonoscopy after mechanical bowel preparation. METHODS Prospective double-blinded randomised control trial. Use of probiotics vs placebo in the setting of patients who have undergone full mechanical bowel preparation and colonoscopy A commercially available probiotic or placebo at recommended daily dose for 7 days after the procedure END POINTS Evaluation of post-colonoscopy symptoms - Abdominal pain - Time taken for patient bowel function to return to normal (the usual bowel habit for them)

When nutrients, including fat, empty from the stomach after a meal, they pass into the small intestine where they stimulate signals that initiate contractions in the stomach, and alter sensations like fullness. These responses to fat appear to differ between lean and obese individuals. We do not fully understand how the small intestine senses or “tastes” the presence of fat, but studies have recently identified a number of molecules, or “sensors”, that are present in the small intestine and interact with fat. We want to determine the number and location of these fat sensors in the intestine, and to evaluate whether there are any differences in their levels between lean and obese individuals. We also want to determine whether there are any relationships between the occurrence of these fat sensors in the small intestine with the way in which the stomach and small intestine respond to fat. Therefore, we will determine how fat, infused directly into the small intestine, changes the number of these sensors, contractions in the stomach and small intestine, and the secretion of hormones in the gut.

A study to evaluate the safety, tolerability and metabolism of MK8226 in healthy volunteers. MK8226 is being developed for treatment of patients with moderate to severe atopic dermatitis. However, this study is in healthy volunteers only.

We propose to conduct a 6-month, randomised, double-blinded placebo-controlled trial to assess the effectiveness of daily calcium and vitamin D supplementation in improving bone material properties at the distal tibia and radius in young male jockeys. The three-dimensional capacity of peripheral quantitative computed tomography (pQCT) to assess bone strength and estimates of fracture risk will be superior to previous reports using Dual X-ray Absorptiometry and will contribute new knowledge to the literature. Bone scans at baseline and 6-months will provide a better understanding of the relationship between supplementation and bone properties, including fracture risk. Project Aims We will test the hypothesis that 800 mg calcium (citrate and carbonate) and 400 IU vitamin D per day is effective in improving bone material properties and reducing fracture risk in young male jockeys by; (i) comparing changes to strength stain index (bone strength) at the tibia and radius in participants assigned to receive a 6-month calcium and vitamin D supplementation or a placebo Secondary aims are to: (i) monitor the proportion of young male jockeys who meet the recommended daily intake of calcium (1300 mg/day) (ii) compare the effects of supplementation on weight-bearing (tibia) and non weight-bearing (radius and ulna) bones

Aim: 1.To develop, implement and evaluate family interventions for supporting families of children with ABI in paediatric inpatient rehabilitation. 2.To compare outcomes of families who receive the family intervention to families who receive the “usual care” social work service during their child’s inpatient rehabilitation. Study Design: A sequential comparison group design. Procedure: Eligible participants will be invited to participate in the study at the time of their child’s admission to rehabilitation. During the child’s admission families will be recruited into the Comparison Group or Intervention Group and will receive “usual care” social work service or family intervention respectively. Participants will complete questionnaires at admission (T1), discharge (T2) and 6 weeks post discharge (T3). Data Analysis: The study will compare outcomes of the Intervention Group and Comparison Group at six weeks post discharge.

The aim of this study is to assess the impact of commercial contact lenses on the global peripheral aberrations and retinal image quality.

To evaluate, in overweight/obese patients with type 2 diabetes mellitus the chronic effects (24 months) of an energy restricted, very low carbohydrate (<50 g/day), low saturated fat (<10%) diet compared to an isocaloric high unrefined carbohydrate, low fat diet on: Primary outcomes: glycemic control, cardiovascular disease risk factors and endothelial function Secondary outcomes: weight loss, body composition, appetite, diet acceptance, renal/bone health.

"GIVE UP FOR GOOD" (Copyright) is a research study, evaluating the effectiveness of a pharmacist-led multidisciplinary system change smoking cessation intervention for smokers admitted to Victorian hospitals. Approximately 200 smokers will be recruited from each of three participating Victorian hospitals (The Alfred, Austin Health & Barwon Health). Participants will have an equal chance of being randomly allocated to either the intervention or usual care (control) group. Participants randomized to "Give up for Good" program will receive a series of smoking cessation counseling sessions by a specially trained pharmacist over the course of at least three sessions. The first during the hospital stay, second on discharge or immediately after the discharge and third within one month post-discharge. All smoking cessation medications during the hospital stay and for at least one week after discharge will be provided free of charge. When participants are discharged from hospital, the pharmacist will communicate with the participant's General Practitioner and community pharmacist about further smoking cessation support. Participants randomized to usual care group receive the current routine care provided by the hospital. All the participants will be followed up for a period of 12 months. All measurements at baseline, discharge, 1 month, 6 months and 12 months will be performed by a Research Assistant blinded to group allocation. The main outcome measures are abstinence from smoking on discharge, and 1 month, 6 months and 12 months post-discharge.

This study aims to compare standard full immobilisation protocols with partial immobilisation for 3 weeks on the functional and treatment outcomes and redislocation rates of individuals with first time patella dislocations. It also aims to examine the effect of generalised joint hypermobility on outcomes after first-time patella dislocation. Hypotheses This study will test the hypothesis that those treated with the partial immobilisation brace will have better functional outcomes with no change in redislocation rates compared to full immobilisation. In addition, it is hypothesised that those treated with full immobilisation, will require more physiotherapy than those treated with a partial immobilisation stabilising brace, in order to regain the same level of function. It is also hypothesised that participants with generalised joint hypermobility will have greater redislocation rates than those who are not hypermobile in both groups.

The aim of this pilot study is to determine the feasibility of a 12-week multi-component anxiety management program for the treatment of anxiety symptoms in people with cognitive impairment.