ANZCTR search results

investigators decided to decline the sponsorship offer.

Aim: This study aims to test the effectiveness of a childhood obesity prevention intervention delivered to first-time parents and focused on parenting skills which support the development of positive diet and Physical Activity (PA) behaviours, and reduced Sedentary Behaviours (SB) in infants. Hypotheses: In comparison to the control group infants, over the course of the intervention, the intervention group infants will: 1. Demonstrate greater increases in consumption of fruits and vegetables, and smaller increases in consumption of cordials, soft-drinks and juices and energy-dense snack foods 2. Demonstrate greater increases in time spent being physically active and smaller increases in time spent in sedentary behaviours, specifically Television (TV) viewing 3. Exhibit reduced incremental Body Mass Index (BMI) gain In comparison to the control group parents, the intervention group parents will demonstrate greater increases in: 4. The frequency with which they offer fruit and vegetables, water and milk (rather than cordials, soft-drinks and juices), and smaller increases in the frequency with which they offer energy-dense snack foods to their child 5. Knowledge regarding infant eating, physical activity and sedentary behaviours and greater development of positive attitudes/beliefs regarding their capacity to influence these behaviours 6. The adoption of desired feeding strategies, including the division of responsibility in feeding and in providing opportunities for modelling of healthy eating 7. The adoption of strategies, including modelling, for increasing opportunities for physical activity and reducing opportunities for sedentary behaviours

19 clinicians within an AOD service on the Central Coast of New South Wales, Australia, will be recruited to the trial. Consenting clinicians will participate in a baseline focus group discussion designed to explore their experiences and perceived barriers to adopting innovation in their clinical practice. Computer comfort and openness to innovation will also be assessed. Throughout the trial, current, new and wait-list clients will be referred to the research program via the clinical service, which will involve clients completing a baseline and 15-week follow-up clinical assessment with independent research assistants, comprising a range of mental health and AOD measures. Clinicians will also complete session checklists following each clinical session with a client, outlining the extent to which the SHADE computer program was used. Therapeutic alliance will be measured at intake and discharge from both the clinician and client perspectives. This study will provide comprehensive data on the factors associated with the adoption of an innovative, computer-delivered evidence-based treatment program, SHADE, by clinicians working in an AOD service. The results will contribute to the development of a model of dissemination of SHADE, which could be applied to a range of technological innovations.

There is abundant observational evidence that midazolam, a benzodiazepine drug used for sedation, use is associated with delirium in ICU patients. However, despite the availability of an equally effective alternative, benzodiazepines usage remains high. The most likely explanation for is that clinicians are not sufficiently convinced by the quality of the observational studies. This is a reasonable criticism, as it is unlikely that it was possible to adjust for all sources of indication bias in these studies. We hypothesise that introducing a clinical guideline for intubated patients in the Austin Hospital ICU that restricts midazolam use to patients with one of a select list of indications will a. reduce the use of midazolam and b. reduce the incidence of surrogate markers of delirium in ICU patients, without c. significantly increasing cost of sedative medications in the ICU.

Infection after c/section is a concern for women and health workers. Prophylactic antibiotics are used to prevent infection but some will still develop the complication. betadine is routinely used for skin preparation prior to c/section. It is believed that its use again immediately prior to skin closure may further reduce the infection rate. This is an open randomsied controlled trial. Hospital infection control dept routinely make contact with all c/section women. This source will be used to gather information on women who develop any problem with ht ewound. They routinely provide consent to be contacted for this purpose and therefore no additional consent will be required .

This pilot study will investigate quality of life issues related to having brain cancer, other cancers which spread to the brain or advanced cancer of other types; where the person is required to take regular dexamethasone (a corticosteroid) for disease management and/or chemotherapy. The study will enable us to follow how patients are doing during their treatment for cancer by looking at the severity and frequency of side effects that occur with dexamethasone, in particular by using a new instrument which assist patients and their caregivers to tell us about the possible side effects they might be experiencing in relation to dexamethasone treatment and their severity. The study will also look at factors that might help us decide how to improve the management of dexamethasone use.

This project is a randomised controlled trial of an established online bulletin board for depression. It has been estimated that millions of people worldwide use peer-to-peer bulletin boards, forums or internet support groups (ISGs) for health conditions. However, little is known about the effectiveness of these groups in terms of symptom reduction or improvement in quality of life. To our knowledge, this is the first randomised controlled trial of the effectiveness of a pre-existing, well-established online bulletin board for depression in the community. The aims of the project are to determine whether BlueBoard, an established online bulletin board for depression, improves mental health, quality of life, and related outcomes among members of the community with high levels of self-reported psychological distress and previous history or current experience of depression.

Around 30-50% of adults will experience neck pain over a 12 month period, and many are treated with manual therapy. Although evidence supports manual therapy treatment when combined with exercise, the dose is not defined. Up until now, there were few methods for objectively quantifying a manual technique to establish its optimal dose. This pilot randomised controlled trial will investigate two specific doses of posterior-to-anterior (PA) mobilisation, the most common manual technique therapists use when treating the cervical spine. Sixty patients will be randomised to receive either a high force or low force PA mobilisation, or sham treatment, with patients’ pressure pain threshold, resting pain, cervical range and stiffness measured before, immediately after and 3-5 days post-treatment. We will utilise innovative equipment we developed to standardise the manually applied forces, conducting the trial using demonstrable methods from our previous research. Determining dose-response relationships for manual therapy is essential for establishing optimal treatment strategies for patients with neck pain. The cost of neck pain is increasing, and many patients do not achieve symptom resolution. Therefore there is an urgent need for physiotherapists to provide effective treatment dosages with demonstrated patient outcomes, impacting spinal pain and advancing physiotherapy as the preferred treatment choice.

The purpose of this study is to assess the safety and tolerability of BMS-919373 in healthy subjects.