ANZCTR search results

Aboriginal children living in remote areas of the Northern Territory have the world’s highest rates of eardrum perforation reported in the medical literature. The disease can have significant effects on a child’s hearing, language, education and associated social disadvantage. Studies show that a child with chronic suppurative otitis media (CSOM) requires frequent daily ear cleaning and antibiotic drops. This may be needed for many months. Regular review of the eardrum is required to monitor progress and provide treatment. Families living in remote communities struggle to provide the level of care needed for effective cure of perforations. Our research will look at ways to increase the rates of Aboriginal children with a history of eardrum perforation participating in follow-up exams. We will randomise families caring for a child with CSOM to receive regular reminders by mobile phone calls, text messages or standard practice. Clinic attendance rates will be the primary outcome.

This study will investigate whether providing cognitive behaviour therapy provides better reduction of postconcussive syndrome symptoms than education about postconcussive syndrome in patients following mild traumatic brain injury. Patients will be randomly allocate patients with postconcussive syndrome to either (a) cognitive behavior therapy, or (b) education, and assessed for postconcussive symptoms following treatment.

A randomised controlled trial (RCT) will be used to evaluate the effectiveness of the BO program; an internet-based CBT program for BN. Participants will be randomly assigned to one of three conditions; (1) BO with therapist assistance (BO-TA); (2) BO automated self help (BO-ASH); or (3) a wait-list control (WLC) group. Participants in the BO-TA condition will be allocated an online therapist (who will be a fully or provisionally registered psychologist) who will email them once per week and whom they can email as often as they wish. Participants in the BO-ASH condition will be sent a weekly automated email reminding them to complete the modules and encouraging them to think about important points from each module. Participants in the WLC condition will have access to the BO-ASH condition after three months. Participants randomised to the intervention conditions (BO-TA and BO-ASH) will complete online assessments at pre, post- and 3-month follow-up. Participants randomised to the waitlist control condition will complete online assessments at pre and post waitlist, as well as post and 3- month follow-up BO. This study is a repeated measures design with three time points. We will employ multi-level modelling to allow for the comparison of the two BO programs and waitlist control condition in terms of changes in clinical diagnosis, BN specific symptomatology, general psychological functioning and quality of life, drop-out, and program engagement while controlling for and testing for any important participant variables such as age, gender and education. In addition, pre-, post- and follow-up variables will be subjected to correlational and multiple regression analyses to determine significant correlates of treatment adherence and attrition and potential predictors and discriminators of successful intervention outcome.

The incidence of bacteria in the urine after radical prostatectomy when patients still have their catheters is not known. How qucikly the bacteria clears after the catheter is removed is also not known. Presence of bacteria is a risk for infection which can increase patient morbidity. We want to investigate the rate of bacteria in the urine before and after catheter removal and the incidence of symptomatic urinary tract infection

This project aims to determine if 12 weeks (three times per week) of high intensity intermittent exercise (HIIE) and green tea consumption leads to significant fat loss and improvements in metabolic markers for diabetes and cardiovascular disease in overweight men. We have shown that HIIE leads to significant fat loss and increase in insulin sensitivity in women and now want to demonstrate this effect in men. The ability of HIIE to increase catecholamline secretion may be the reason why this form of exercise combined with green tea consumption results in more fat loss compared to exercise such as walking and jogging. We hypothesize that exposure to 12 weeks of HIIE and green tea will result in: - significant subcutaneous and visceral fat loss - significant increases in insulin sensitivity - significant increases in aerobic and anaerobic fitness We also hypothesize that: - greater hepatic fat loss will occur when green tea is consumed with HIIE

Due to the results of previous studies both in vivo and in vitro, we hypothesised that curcumin may decrease paraproteinemia and bone turnover in MGUS and indolent myeloma patients. A pilot study conducted by us showed a reduction in paraprotein levels and the uNTX bone turnover marker in a select group of MGUS patients. This trial is a continuation of the pilot study and we aim to prove that curcumin may act to prevent the progression of MGUS to active myeloma.

This study is designed to evaluate the pharmacokinetics, safety and tolerability EMA401 in healthy elderly subjects (56 years and over) after two single oral doses of EMA401 Sodium Salt administered on the same day with a 10 hour interval between doses, for a total daily dose of 200 mg.

This study will involve taking a venous sample from the same venepuncture uses as a part of their normal routine treatment and an additional two capillary finger stick samples from all participants. Samples collected are tested on both the medical device and the laboratory reference.

The purpose of the trial is to conduct a prospective randomised controlled trial of Versajet hydrosurgery debridement (removal of necrotic/ non-viable tissue) of burns versus conventional tangential excisional debridement in paediatric patients. To date no trial has compared excisional debridement with Versajet hydrosurgery in paediatric burns patients. Our hypotheses is that 1.Versajet debridement leads to increased dermal preservation and accuracy of debridement 2.Versajet debridement is faster than conventional tangential excision in areas that are difficult to debride such as the hands, feet or perineum. 3.Graft healing time is equivalent following Versajet or classical blade debridement 4.Versajet debridement leads to improved outcomes post skin grafting such as hypertrophic scarring and contracture 5.Bacterial load is lower in the Versajet group following debridement

Obesity and asthma are two of the most common conditions affecting Australian children and adolescents. Epidemiological studies have indicated a link exists between obesity and asthma. Obesity is associated with chronic systemic inflammation. Given that asthma is characterised by chronic inflammation of the airways, we hypothesise that obesity is amplifying airway inflammation and impacting adversely on clinical asthma outcomes in children and adolescents.