ANZCTR search results

The objective of the study is to determine how effective imiquimod cream is in curing lentigo maligna and whether it is a possible replacement for surgical excison as the primary treatment.

The primary objective is to determine whether or not a rehabilitation physician appointment can help with return to work (full or suitable duties) and usual activities after a motor vehicle accident..

Primary Aim: To assess the effect of recombinant LH (rLH) use in patients undergoing IVF/ICSI who experience a 50% or more reduction in serum LH concentrations from the early to mid follicular phase. IVFAustralia has performed a retrospective pilot cohort study, which in 701 cycles of IVF/ICSI revealed that a reduction 50% or greater from early to mid-follicular LH concentrations resulted in significant reduction in live-birth rate (Lahoud et. al., 2006). Research Design:Prospective Randomised Controlled Trial Study population: Patients undergoing IVF/ICSI treatment at IVFAusralia. Intervention: The treatment group will receive 75 IU of rLH (Luveris) from day 7 of FSH administration until and including the day of HCG administration. Primary outcome: Clinical Pregnancy Rate

The ‘Using the Internet to support breastfeeding duration’ project will be conducted from 2009-2013. Women from regional WA will be invited to take part in the project where they will be exposed to a high level of support through the Internet. The breastfeeding outcomes of these women will be compared with women from regional WA who only access those services normally available to them.

The current study aims to evaluate the efficacy of an internet based psychological program for people who are concurrently depressed and drinking alcohol at harmful levels. This study is a randomised controlled trial with 3 comparison treatment, each with 200 participants who will be followed up for 12 months. The 3 treatments to be compared are: 1) brief intervention (BI) (1 module of motivation enhancement) 2) BI + self-guided modules (SG) (1 module of motivation enhancement + 5 modules of self-guided integrated treatment 3) BI + therapist-support (TS) (1 module of motivation enhancement + 5 modules of integrated treatment with email support from a therapist) Primary predictions are that 1) TS and SG interventions will have superior alcohol and depression outcomes at 3, 6, 9 and 12 months compared with BI and 2) TS will elicit greater client satisfaction and completion rate than SG, but SG will have similar treatment outcomes.

to assess the effect of lenalidomide consolidation (vs observation with no further therapy) in previously untreated CLL patients with measurable disease after at least 4 cycles of FCR therapy.

Mild zinc deficiency has been reported in general aging populations due to numerous factors as previously reported by the International Zinc Nutrition Consultative Steering Committee. Zinc deficiency may cause impaired immunity, increased DNA damage, delayed wound healing, depression, impaired cognitive function and increased oxidative stress. As zinc deficiency can affect the health of ageing individuals, it is important to maintain an adequate zinc status within this population. To date, there is no data available on the benefits of zinc supplementation in an ageing Australian population.The findings of this research may provide knowledge on the effect of zinc supplementation in an elderly population in relation to DNA health (i.e. prevention of DNA damage). We believe there is a strong likelihood that these outcomes will be achieved by this study. Study hypotheses is zinc supplementation increases zinc status, reduces DNA damage and improves cell growth in both lymphocytes and buccal cells in elderly individuals.

The target population for this study includes CML patients of any age residing in Australia or New Zealand with CML who have stopped TKI for any reason. Patients will be observed by there regular clinician and data submitted to the central trial coordinating centre.

Longitudinal Cohort study of outcomes in children with Joint hypermobility and the relationships between signs and symptoms, function, participation and outcomes.

This study examines whether patients presenting to emergency with chest pain can be managed more rapidly than current standard care. The current process involves blood tests over 6-24 hours. The study study examines the safety of an ‘accelerated chest pain algorithm’ . That is whether combining the results of blood tests such as Troponin I, creatine-kinase MB fraction (CK-MB), and myoglobin over a 2 hour time period from presentation with a risk stratification process allows early futher testing or discharge of patients with potential acute coronary syndrome (ACS). These results will be used to develop a pathway for investigation of pateints with potential acute coronary syndrome (ACS) in the Emergency Department.