ANZCTR search results

This study will investigate whether two interventions; omega-3 fatty acids supplements (fish oil) and the antidepressant, sertraline, are able to reduce or prevent depression and cognitive change. The study will run over 12 months and participants will be randomly allocated to one of the interventions or to a placebo condition. Participants will be assessed at different time points by telephone interviews, self report surveys, medical examinations and brief psychological assessments. These assessments will look at the effectiveness of the two interventions in reducing symptoms of depression and/or new cases of depression and reducing cognitive decline (e.g. changes in memory, concentration and thinking) associated with ageing. Additionally, because depression is believed to have a biological basis and because both these interventions influence brain activity, participants will also be invited to have three brain scans over the time of the study. We hope to track the effects of fish oil and sertraline on the brain changes associated with the normal ageing.

To determine the efficacy of iCBT in anxiety and depression

Circulating testosterone levels in young healthy women exceed those of oestrogen and by the time women reach their 40s, their blood testosterone levels are about half those of women in their 20s. Restoration of testosterone levels in postmenopausal women to those of younger women improves several aspects of cognitive function using conventional tests of cognitive performance. More recently, in a pilot study of postmenopausal women given transdermal testosterone over a period of 26 weeks we observed improved verbal and visual learning and memory using highly sensitive measures of cognitive performance. The aim of this study is to use these sensitive measures of cognitive function, which can detect subtle changes in cognitive performance in well older individuals, in a randomised placebo-controlled trial to determine whether restoration of blood testosterone levels in older women to those of premenopausal women over 26 weeks enhances cognitive performance when compared with placebo therapy.

After anaesthesia children frquently become irritable and distressed. This is termed Emergence Delirium (ED). Sometimes this can lead to intravenous lines and surgical drains becoming dislodged. The child rarely remember this period and it rarely has any longterm consequences. A number of studies have suggested that a commonly used anaesthetic drug called propofol can be used to reduce the chance of this happening. We plan to administer a dose of propofol at the end of an anaesthetic to see whether it will reduce the rate of ED.

This study will compare the new insulin pump with low glucose suspend feature with current pump therapy to see if there is any change in rates of hypoglycaemia.

The primary purpose of the study is to provide investigators with the information necessary to carry out a clinical evaluation of the SJM Epic Valve. In doing so the study will collect information to establish the adverse effect rates, clinical status as indicated by NYHA functional classification and hemodynamic performance.

To obtain “real-world” clinical outcomes of neuromodulation in patients with St. Jude Medical Neuromodulation Division devices. An observational registry is defined as non-interventional research that involves the collection of scientifically valuable information for the purpose of answering important research questions. The term 'non-interventional' means that the healthcare provider's decisions regarding the proper treatment and care of the patient are made in the course of normal clinical practice.

The primary objective of the study is to evaluate the safety and effectiveness of the AqueSys Implant for the treatment of ocular hypertension and open angle glaucoma.

Helicobacter pylori (H. pylori) infection is a common stomach infection affecting ~50 % of people worldwide. In most cases, patients have no symptoms. H. pylori infection does induce immune responses, however they are not protective. For these reasons Ondek Pty Ltd is developing H. pylori as a live bacterial delivery system for vaccines and other therapeutic agents. The aim of this study is to find strains of Helicobacter pylori which can be safely used as a vehicle for the delivery of vaccines such as that used to treat Influenza in humans. Here we would like to assess the suitability of H. pylori strains as a live bacterial vector, and identify clinical isolates with a safe profile in humans.

This study will randomly allocate patients with PTSD to either (a) imaginal exposure, (b) in vivo exposure, (c) combined imaginal and in vivo exposure, or (d) combined imaginal, in vivo exposure, and cognitive restructuring.