ANZCTR search results

The study will determine the efficacy of an 8 week (x 6 session) face-to-face education and skill development program targeting the self-management of nutrition, physical activity and healthy weight management for cancer survivors who have finished active cancer treatment, and their partners/caregivers.

This project is part of a research program examining the efficacy of Internet based education and treatment programs for people with social phobia and other commmon mental disorders. This project compares the effectiveness of simple written motivational strategies at encouraging people with social phobia to complete the 8 lessons in the Program. We expect that people who receive the motivational exercises (in addition to weekly reminder emails) will complete more lessons and report greater benefit from the program than participants who do not receive access to the motivational strategies, but do receive email reminders.

This study aims to evaluate the impact of a brief intervention delivered by community nurses in routine practice on the change in clients’ lifestyle risk factors.The trial will use a quasi experimental design involving four generalist community nursing sites in NSW Australia. Sites will be randomly allocated to ‘early intervention’ group or ‘late intervention’ (comparison) group. ‘Early intervention’ sites will be provided with training and support for nurses in identifying and offering brief lifestyle intervention for clients during routine consultations. ‘Late intervention’ sites’ will provide usual care and be offered the study intervention following the final data collection point. A total of 720 eligible generalist community nursing clients will be recruited at the time of referral from both early and late intervention sites. Data collection consists of 1) telephone surveys with clients at baseline, three months and six months to examine change in SNAP risk factors and readiness change 2) nurse survey at baseline, six and 12 months to examine changes in SNAP risk factor confidence, attitudes and practices 3) semi-structured interviews/focus with nurses, managers and clients in ‘early intervention’ sites to explore the feasibility, acceptability and sustainability of the intervention. The study will provide evidence about the effectiveness and feasibility of brief lifestyle interventions delivered by generalist community nurses as part of routine practice. This will inform future community nursing practice and Primary health care (PHC) policy.

The aims of this study will address the following hypotheses, that: The daily topical application of EMLA cream to the wound bed reduces pain levels for patients with a chronic leg ulcer. Improvement in pain levels will be associated with reduced need for oral analgesia, particularly opiates. Topical application of EMLA cream to the wound bed decreases healing time for chronic leg ulcers Improvement in leg ulcer pain and/or wound healing will be associated with gains in health-related quality of life. Hypothesis Our hypothesis is that the daily topical application of EMLA 5% cream to the wound bed of painful chronic leg ulcers as the primary dressing, will reduce wound-related pain and analgesic requirements, and improve the quality of life for patients with painful chronic leg ulcers. The secondary outcome measure is decreased wound healing times. As the primary outcome measure is pain reduction, this study will investigate painful chronic leg ulcers of varying aetiology, including venous, arterial and/or mixed ulceration.

The hypothesis that this trial will test is that the citrate/calcium approach for regional anticoagulation is more effective than the heparin/protamine method at maintaining functional filter life in patients receiving continuous renal replacement therapy (CRRT). CRRT is the form of dialysis that is used in the intensive care unit for critically ill patients. Blood is removed from the patients body and circulated through a membrane before being returned. This circuit outside the body causes the blood to start clotting unless a drug is used to prevent this happening. We will compare two different methods of preventing this clotting to see which one can prevent the blood clotting for the longer time. Prevention of blood clotting in the circuit is desirable because of the interruptions in treatment that this causes.

The primary purpose of this study is to determine whether participating in a 6-month strength training program can improve the strength, body shape and self-esteem of teenage boys. It is anticipated that at completion of the 6-month strength training program participants who took part in the intervention will show greater improvements in their self-esteem, strength and body shape relative to those participants who did not take part in the intervention.

This study looks at the effectiveness of early treatment intensification with R-ICE chemotherapy followed by high dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) if positive PET/CT, or a further 2 cycles of R-CHOP-14 if negative PET/CT in patients with lymphoma which is classified as CD20 positive diffuse large B cell type who have received an initial 4 cycles of R-CHOP-14 chemotherapy. Who is it for? You can join this study if you: have lymphoma which is CD20 positive diffuse large B cell type (DLBCL) have either low intermediate, high intermediate, or high risk disease, or low risk disease with bulky tumour (> 7.5 cm) are considered fit and eligible for high dose chemotherapy(HDCT) and autologous stem cell transplantation (ASCT) have not received previous treatment for lymphoma. Trial details All participants will receive treatment with R-CHOP-14 chemotherapy every fourteen days over four cycles. They will then undergo PET/CT scanning. Participants who have scans that show the disease remains active will have their treatment intensified with R-ICE chemotherapy followed by HDCT with Z-BEAM (a special chemotherapy regimen) and ASCT. If the scans show that the cancer is no longer active, they will receive a further two cycles of the R-CHOP-14 chemotherapy. The study aims to monitor participants to see the effectiveness of this new treatment, particularly in relation to an expected increase in the number of patients who remain disease free after two years.

Patients with advanced liver disease and ascites (intra-abdominal fluid) are at high risk of bacterial infections such as spontaneous bacterial peritonitis. Once daily antibiotics such as trimethoprim-sulfamethoxazole is considered standard treatment to prevent bacterial infections in this setting. However, breakthrough infections are still common. The study hypothesis is that a higher dose of antibiotics may be more effective in preventing bacterial infections in advanced liver disease. The purpose is therefore to conduct a trial to examine whether twice daily trimethoprim-sulfamethoxazole is more effective than the standard once daily dose at reducing bacterial infections and admissions to hospital in these high risk patients.

The Kids - 'Go for your life' initiative aims to improve healthy eating and physical activity levels of children and in do so reduce the risk of overweight and obesity. To achieve this aim Kids - 'Go for your life' primarily works with primary schools and early childhood services, such as child care, family day care, and kindergartens, to support healthy eating and physical activity through and Award Program, using a health promoting schools approach. Schools and services join the program as member and receive a range of resources, training and support as they work through a number of crieteria to improve their policies and practices and reach award status. This Award program is supported within local communities by local government and community organisations.

To evaluate the hypotheses: (i) that both oral and small intestinal exposure to oleic acid (C18:1) will modulate antropyloroduodenal pressures, gut peptide, OEA and serum triglyceride responses, and suppress energy intake (ii) that combined oral and small intestinal exposure to oleic acid will interact to enhance the stimulation of antropyloroduodenal pressures, gut peptide, OEA and serum triglyceride responses, and suppression of energy intake, when compared with either oral or small intestinal infusion alone, and (iii) that these effects will occur in “tasters”, but not “non-tasters”, of oleic acid.