ANZCTR search results

This study draws on the observation that there are genetic, clinical and neuropsychological similarities between Borderline Personality Disorder (BPD) and Attention-Deficit/Hyperactivity Disorder (ADHD). Since psychostimulants such as methylphenidate are the mainstay of treatment of ADHD, it is proposed that psychostimulants be trialed in a population of female adolescents with BPD, with the intention of enhancing our understanding of BPD and providing a novel treatment option for this difficult-to-treat condition. Hypothesis: That selected patients with BPD will respond positively to a trial of methylphenidate.

Dantonic Pill (DP) is a pharmaceutical product derived from medicinal herbs Salvia miltiorrhiza and Panax notoginseng. DP has been registered in China for the prevention and management of atherosclerotic cardiovascular disease for over ten years. Clinical trial studies in China have demonstrated that DP has few side effects and Asian people are well tolerant of the DP therapy. To date, DP is also availbale in many herb shops in Australia and however, the data concerning the tolerance and side effects of this product in Western population are limited. This project study aims to investigate the tolerance and general physiological responses to DP in Western people, through assessment of the symptems, blood pressure, electrocardiogram (ECG), bloof cell count, blood lipids and glucose, and liver and renal function in healthy adult Westerners folllowing a single dose of DP therapy.

An observational pilot study to assess the burden of subclinical gout during an acute attack and during an intercritical period through asssessment of ultrasound detected synocial hypertrophy and urine hyaluronan

Patients from Royal Perth hospital with gout of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation.

The purpose of this study is to determine whether literacy instruction using the ABRACADABRA (ABRA) program 30 minutes per day, 4 days per week for one Semester improves student literacy in the Northern Territory (NT) moreso than traditional literacy instruction. ABRACADABRA (ABRA) is an online web-based early literacy program designed by Concordia University in Canada according to best practices in literacy instruction. The study tests the hypothesis that students who receive ABRA instruction will have higher scores than students who do not receive ABRA instruction on two measures of foundational skills for future reading: 1) phonemic awareness (recognition of the sounds in the English language) and individual word reading.

Patients from Royal Perth hospital with osteoarthritis of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation.

The primary purpose of this study is determine the best method for transporting respiratory specimens for viral studies from remote Indigenous communities. The study will enable planning for respiratory illness surveillance and interventions in remote areas. The primary hypothesis is that there is no difference in the proportion of respiratory viruses detected in nasal swabs collected from children and adults in the community that have been frozen immediately compared to specimens that have been sent via routine post.

The purpose of the study is to determine if an intra-gastric balloon in combination with a lifestyle program has a benefit for obese adolescents, compared to a lifestyle program alone.

Shift workers have been found to be at increased risk of insomnias, chronic fatigue, anxiety and depression, cardiovascular and gastrointestinal problems. Several well controlled epidemiological studies suggest that exposure to shift work is associated with increased health problems compared with working normal daytime hours and is an independent predictor of increased body mass index and obesity prevalence. The aim of this study is to evaluate the effectiveness of a workplace-based weight-loss program developed specifically for overweight and obese male shift workers.