ANZCTR search results

This study looks at the effectiveness of the pain-killing drug ketamine in people with widespread cancer who are receiving palliative care and have difficult cancer pain that does not respond well to opioid drugs. Who is it for? You can join this study if you have widespread cancer and are receiving palliative care, and have difficult cancer pain that does not respond well to opioid (morphine-like) drugs. Trial details Participants will be divided into two groups. One group will receive five days of treatment with increasing doses of ketamine given under the skin (sub-cutaneously), and the other will receive a non-active compound (placebo) also given under the skin. Blood samples will be collected. The study will assess pain control, quality of life, side effects from ketamine, and reduction in the need for usual pain medicines. The study nurses and the doctors and nurses in the ward will monitor all participants closely for any unexpected problems and to ensure that pain is managed appropriately. Ketamine may be helpful for pain related to cancer, especially pain resulting from nerve damage. However studies to date are incomplete and evidence is needed to support continued clinical use. It is hoped that after this study, if ketamine is proven safe and effective in difficult cancer pain, it will become more easily available for Australian cancer patients.

The aim of this study is to develop and test a rigorous acupuncture study design that will determine if acupuncture has a significant therapeutic effect in the treatment of depression. This will increase the understanding of how acupuncture can be effectively used as an adjunct therapy to treat depression and may lead to reduced drug dependency and side effects for patients. Subjects will need to be medically diagnosed as having major depression and be taking serotonin uptake inhibitors (prescribed medication). They will also be screened for the Traditional Chinese Medicine (TCM) diagnostic pattern of liver qi stagnation. Subjects will be treated with acupuncture and the outcomes of the treatment assessed using standard questionnaire/assessment tools.

The primary purpose of this study is to investigate the hypothesis that a multifactorial, multidisciplinary falls prevention programme can prevent falls in an acute hospital setting.

The study aims to evaluate the diagnostic accuracy of a new cellular imaging device for identifying endometriosis lesions during surgery which require treatment or removal.

Overall, there were two key aims of the current study. First, to assess the effectiveness of perfectionism and media literacy programs compared to control classes, in attempting to reduce eating disorder risk factors. Outcomes were examined with the targeted variables (perfectionism, media internalization and perceived pressure to be thin) as well as other eating disorder risk factors (e.g., shape and weight concern, dietary restraint, depression, self-esteem etc). Second, to qualitatively assess students’ perceived value and enjoyment of the respective programs. This was the first time an eating disorder prevention program targeting perfectionism had been evaluated.

This study will evaluate the safety (i.e. incidence and type of adverse events) and efficacy (i.e. change from baseline in the 4 symptom nasal score for the entire double-blind treatment period) of CMP administered three times daily intranasally over a four week period to people with seasonal allergic rhinitis (SAR) as compared to placebo.

The aim of this clinical study is to determine how well a new prolonged release oxycodone/naloxone combination tablet works in reducing constipation whilst still giving the patient the required amount of pain relief in patients suffering from cancer pain.

The primary purpose of this study is to determine whether PES is an effective treatment choice for people with osteoarthritis of the knee. The hypothesis is that PES will produce a clinically important and sustained improvement in pain, function, patient global assessment, quality of life and physical activity when compared with placebo treatment in individuals with osteoarthritis of the knee.

The primary purpose of the study is to investigate the effects of vibration platform training on bone health in postmenopausal women. The primary hypothesis is that vibration training will be associated with an increase in blood borne markers of bone metabolism after 8 weeks.

There is no update to the original ethics submission