ANZCTR search results

We will examine the efficacy of an Internet based education program for improving the mental health of people with social phobia. Participants will be recruited via a website developed for this Program (www.shyness.tv), and a structured diagnostic interview via telephone. Consenting participants will be randomly allocated to an active Education Group, or Wait-List Control Group. Participants will complete six lessons of CBT based education delivered via the Internet and weekly emails from a clinician, weekly homework, and weekly contact with other participants via an online discussion board. Participants will be assessed at application, prestudy, one week poststudy, and 6 months poststudy. Once the Education Group have completed the lessons the Control Group will be given access to the lessons.

ProsCan will follow men with prostate cancer from the time of diagnosis to five years post-treatment to better understand their patterns of care and the resulting impact of diagnosis and treatment on their psychosocial, physical functioning and quality of life outcomes. In addition, the genetic biomarkers of prostate cancer will be investigated with particular emphasis on the relationship between biomarkers and clinical/medical outcomes. The project will evaluate whether there are subgroups of men who have better or worse outcomes based on the analysis of psychosocial and prognostic markers. Men with localised cancer will be offered the opportunity to participate in a randomised-controlled trial evaluating a telephone-based nurse-delivered, broad reach supportive care intervention. The intervention will provide support for treatment decision-making, managing the side effects of treatment, and stress management with the goal of improving quality of life. This is one of the first Australian large-scale longitudinal studies to track men with prostate cancer from the point of diagnosis and to follow them over time, and the first study internationally to assess this type of supportive care intervention.

It is known that transition from paediatric to adult care in Type 1 dibetes mellitus is often difficult. Young people are anxious about leaving a familiar service. In adult health care they are 'diluted' where Type 2 diabetes mellitus predominates. Australian figures suggest that up to 50% of young adults with Type 1 diabetes are not in specialist care. Failure to engage with specialist care means poor diabetes care and control, and the risk of medium and long term poor health outcomes. We hypothesise that a comprehensive transition program involving communication, mentoring and health professional support will improvement engagement with adult health care better than current clinic practice.This study aims to determine what resources and support are needed to ensure that successful transition occurs. The literature suggest that it is not enough that young people arrive at their first appointment to an adult service; they need to stay engaged and hence the reason for the longer term nature of the study, following young people for up to 18 months after discharge from paediatric servcies

This is a pilot study designed to gather data pertinent to the development of a large scale clinical trial, The study is an open label trial to be conducted over 12 weeks in otherwise healthy individuals. The study will compare baseline Comprehensive Osteoarthritis Test (COAT) measurements with end of study outcomes

The purpose of the study is to determine the efficacy of Evogen® Topical gel in relieving pain in participants with diagnosed osteoarthritis of the knee. The study hypothesies that the application of Evogen® Topical gel four times a day for 1 week will produce a 50% reduction in pain level.

Stem cell transplant recipients will receive an infusion of donor cells at least one month post transplant. Cells will have been stimulated in the laboratory so that they specifically recognise and kill parts of the viruses known as cytomegalovirus and adenovirus.

The primary purpose of this pilot study is to assess the clinical tolerability and safety of a new synthetic soft tissue implant material in the skin of healthy volunteers.

This is a multicenter, randomized, open-label, assessor-blind, event-driven, non-inferiority program for efficacy with a study treatment duration of 3, 6 or 12 months in patients with confirmed acute symptomatic PE with or without symptomatic DVT (Einstein-PE). (11702b) This is a multicenter, randomized, double-blind, placebo-controlled, event-driven, superiority study for efficacy. Patients with confirmed symptomatic DVT or PE who completed 6 or 12 months of treatment with rivaroxaban or VKA are eligible for this trial (Einstein-Extension study). (11899)

Use of chemotherapy and growth factors can affect the number of stem cells and cancer cells in blood circulation. Few studies have also shown that number of cancer cells can be of prognostic significance. There are no studies till date which have looked systematically at the influence of chemotherapy and growth factors on these cells. Hence present study was designed to answer these questions. The results of the study may not directly influence the way we treat the patients today but will definitely help us to understand the complex nature of breast cancer.

A randomised within-subjects design will be used to determine the effect of regular passive movements on the ankle. One ankle of each subject will receive 20 minutes of passive movements, five days a week for 6 months. The other ankle will not receive passive movements. The primary outcome measure is passive ankle dorsiflexion with the application of 17Nm torque. All measurements will be taken by blinded assessors.