ANZCTR search results

The study has been designed to test how effectively and rapidly a number of new nicotine replacement treatments - nicotine oral pouch, mouthspray and lozenge - relieve the discomfort that people experience when they stop smoking (called withdrawal symptoms) compared to a currently available nicotine replacement product (nicotine gum) and a “dummy” (placebo) product (with no nicotine in it). These new products may deliver nicotine to the body faster than existing products, and it is thought that faster delivery of nicotine may help reduce the discomfort that goes along with stopping smoking. The study will also ask about the level of satisfaction people experience after using the different products.

To undertake a formal clinical trial using videotelephony to support regional and remote families returning home with a child newly diagnosed with cancer

Subjects who have been using chronic CPAP therapy will be invited to participate in the study. The study will take place after the subjects have been instructed on the details of the trial and have provided informed consent. Subjects are randomised to one of two nights in the sleep laboratory. Under polysomnography and using an auto-titrating CPAP (AutoCPAP) systems, the subjects will be studied either under a sub-therapeutic pressure level for one night of recording (simulating a sub-standard therapy night – encountered by clinical patients), or on the AutoCPAP device in the therapeutic auto-titrating mode (which is also a commonly applied therapeutic device). The study is observational in that the purpose and endpoints are collected as described below, under conditions in the laboratory simulating ‘normal’ clinical occurrences. Sleep and breathing parameters will be collected using standard laboratory methodologies, with the addition of flow measurement from four different sites: nares via a cannula; the CPAP machine flow outlet; the electronic output from the CPAP machine and the standard nasal mask via an oxygen port. Integrity of the flow signal as well as the presence of ‘break-through’ apnea / hypopnea phenomena are evaluated.

Metabolic syndrome is a cluster of cardiovascular risk factors such as diabetes, hypertension, obesity, and abnormal cholesterol and blood fat levels. At present there is no single pharmaceutical agent which can effectively treat metabolic syndrome, but rather, multiple medications are given for each risk factor. In China, two mushrooms- Ganoderma lucidum and Cordyceps sinensis, have been used for these conditions and animal, in-vitro and small human studies indicate positive effects against the multiple components of metabolic syndrome. This study will be the first randomised clinical trial of this intervention for the efficacy and treatment of metabolic syndrome.

The purpose of this trial is to determine the effect of high-dose vitamin C on muscle strength, nerve function, gross motor coordination and health-related quality of life in children with Charcot-Marie-Tooth disease type 1A. We hypothesise that muscle strength, nerve function, gross motor coordination and health-related quality of life will be greater in children with Charcot-Marie-Tooth disease type 1A who receive dietary vitamin C supplementation compared to children receiving the placebo.

This study aims to find out if giving a single dose of parecoxib intravenously in theatre improves pain relief following surgery for dilatation and curettage with or without hysteroscopy.

This project aims to work with the NSW Stroke Recovery Association's Stroke Club network to establish and evaluate community -based sustainable exercise programs for stroke survivors. We hypothesis that the experimental intervention ( weekly exercise class and home program for 12 months) will prevent falls and enhance mobility and increase habitual physical activity levels among people following stroke.

Abstract Objective To determine whether giving mothers in Neonatal Intensive Care Unit (NICU) audiorecordings of their conversations with neonatologists improved maternal recall of information and psychological wellbeing. Design: Randomised, clinician - blinded trial with mothers in a NICU either receiving or not receiving audiotapes of their conversations with neonatologists. Participants 200 mothers of babies in a tertiary NICU in North Queensland, Australia Null hypothesis: Providing mothers with an audiotaping of their conversation with neonatologists does not improvetheir recall of infromation about their babies nor the parental well being. Outcome measures: Outcomes (at ten days, four months and 12 months) included recall of information, attitudes towards and use of the audiotape, satisfaction with conversations, post natal depression, parental anxiety, general health and parenting stress. The information conveyed by the neonatologists was coded from transcripts of the audiotapes and matched against the mothers’ recall of the information as measured by interview. All analyses were by intention to treat.

Rifampicin increases bilirubin level in blood, in a small proportion of individual. This is because of deficiency of an enzyme called UGT (uridine diphosphate (UDP)-glucuronosyl-transferase ). The same enzyme metabolizes the chemotherapy drug called Irinotecan. If somebody has the deficiency of the UGT enzyme, they will be at increase risk of toxicity from irinotecan treatment. In this study we are trying to do the same. We will give rifampicin tablets and check whether bilirubin increases or not. Then the irinotecan treatment as scheduled will be given. The side effects from the treatment will be noted. We will try to find if by doing a simple blood test, one can predict if a particular patient is at risk of irinotecan toxicity.

We propose to conduct a randomised controlled trial to compare the effect of eggs to a similar amount of protein and kilojoules from meat fish and chicken in the context of a high protein energy restricted dietary pattern. Primary outcome variables are LDL cholesterol and other cardiovascular risk factors. Our hypothesis is that daily consumption of 400mg dietary cholesterol as 2 eggs compared to an equivalent protein source low in saturated fat and low in cholesterol a kilojoule restricted diet will not adversely affect these outcomes We also propose to opportunistically compare the impact of these dietary patterns on post prandial glucose metabolism, cognitive function and satiety.