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Investigator initiated separate sub-study to the VYTUL study to measure novel serum biomarkers associated with increased heart disease risk to ascertain whether these biomarkers are predictive of response in this population and whether further work on targeting these biomarkers is warranted. A second part to the substudy will focus on exploring non-physiological external factors that may contribute to ineffective risk factor modification and ultimately increased CHD risk in this population.

Study Hypothesis: We hypothesise that participants receiving the subvastus approach will enjoy better medium term funtional outcomes than those receiving the medial parapatell approach. Physiotherapists are blinded to the intervention and will collect all outcome measures at each assessment point. Participants are blinded to the intervention.

The trial assessed the effect of different oxgen saturation targeting ranges on the long-term growth and development of oxygen-dependent, extremely preterm infants.

To determine if the introduction of Vytorin will be more effective than increasing the dose of Atorvastain in achieving LDL ('bad cholesterol') and other cholesterol level goals in high risk patients who have been treated for at least the last three months with atorvastatin 40 mg and still have uncontrolled cholesterol levels.

Patients with relapsed or refractory lymphoma require initial salvage chemotherapy to control their disease. One type of salvage chemotherapy is Rituximab, Ifosfamide and Etoposide (R-IE) given for six cycles administered every 21 days, followed by two additional doses of Rituximab at intervals of 21 days. Ifosfamide and Etopside are given on days 1 to 3 and Rituximab is given on day 1. On the day following each cycle of the R-IE therapy (day 4) a single injection under the skin of pegfilgrastim is given to prevent the white blood cell count from falling too low and therefore reduce the number of infections the patient may experience.

The ProTaT trial is a phase II trial evaluating the safety and activity of the combination of docetaxel (Taxotere), prednisone and Thalidomide in men with metastatic hormone refractory prostae cancer. The hypothesis is that the combination of a standard systemic therapy, docetaxel, with and antiangiogenic agent may improve the response rate in patients with this disease.

Heart disease is Australia's biggest health problem, affecting nearly 3.7 million people every year. Recent research has shown that emotional problems such as depression can make heart problems worse. However, it is often difficult to diagnose depression in people with heart problems. This research aims to improve the general health and wellbeing of people with chronic heart problems and depression by determining whether a special general practitioner enhanced education program, comprising the monitoring of depression, academic detailing of best-practice guidelines and psychiatric advice to the treating GP, will reduce depression in people with chronic heart probalems.

This trial will determine the safety and activity of giving two new drugs together in women with advanced breast cancer. Both of these drugs are active when given alone; giving them together may be better.

The degree of movement in the Cervical and Thoracic Spines contribute to the effectiveness of breathing. In cases of respiratory disease, the degree to which this movement may limit breathing potential is well understood. However, strategies that address correcting such limitations are not as well documented. Furthermore, the inclusion of such strategies within respiratory rehabilitation programs is yet to be investigated. This study aims to test the effectiveness of Spinal Manipulation as a co-management strategy for use within a respiratory rehabilitation setting. The overall aim is to test a new respiratory rehabilitation program that includes Spinal Manipulation as a standard component in the management of certain chronic respiratory conditions.

Younger subjects with type 1 diabetes are being encouraged to undertake exercise, with no limitation on type/intensity of exercise (providing that there are no complications of diabetes present, e.g. cardiovascular disease), however, there is very little scientific information on the response of those with type 1 diabetes to intense exercise, and almost no studies on the response of these patients to high intensity exercise training. This study aimed to compare the metabolic (e.g. blood and muscle lactate, blood glucose) and ionic responses (e.g. muscle sodium potassium adenosine triphosphatase, blood potassium, blood acidosis) during high intensity exercise, as reflected in samples of blood, muscle, and expired gas analysis, in younger people with and without type 1 diabetes; and secondly to evaluate the responses of both groups to high intensity exercise training. We hypothesised that acute exercise responses would be similar in the subjects with and without type 1 diabetes; and that high intensity exercise training would improve metabolic and ionic responses during high intensity exercise in subjects with type 1 diabetes; and would not result in deterioration of overall metabolic control (reflected by glycosylated haemoglobin).