ANZCTR search results

Diabetic patients will be randomised to receive one of two commonly used anaesthetic drugs to maintain general anaesthesia whilst on cardiopulmonary bypass. We will be investigating which one offers better cardioprotection as determined by measuring an enzyme called cardiac troponin i. This enzyme is commonly measured to detect whther a myocardial infarction "heart attack" has occurred.

This project seeks to study the impact of the WHO international classification of functioning and disability looking at contextural factors affecting people with MS. Secondly to provide specific targetted rehabilitation intervention to the identified problem areas reported by the MS cohort and further to measure and quantify the selected functional and social outcomes from rehabilitation intervention. Specific research questions include: - establishment of a database to document the prevelence of medical social and functional parameters for a community dwelling cohort of patients with MS. - to study and compare the effects of disablement on everyday living activities and participation in these persons. This will be done by: a. record the patient's perceived problems due to MS and their coping ability using an open ended questionnaire. b. to determine the perspective of their partners/carers regarding problems living with MS. c. determine the perspective of the treating general practitioner/neurologist regarding problems living with MS. d. to determine the impact of these listed problems and the distress caused on these patients with measured effects on activities and participation using the WHO ICF classification. - Determine burden of care for the partner/carer, - Study the impact of fatigue in persons with MS in the everday activities of daily living and function. - To measure the impact of defined personal factors such as (depression, anxiety, stress) on the everyday activities and participation. - Measure the impact of defined environmental factors that affect function and participation in this group. - Record a generic indicator of health status measure using a general health questionnaire. - To ascertain self efficacy in this patient group and their carers. - To provide targetted rehabilitation intervention for these identified problems and measure specific functional and social outcomes.

This study aims to treat a sub-sample of these young people with an adjunctive integrated CBT intervention and to examine the acceptability of this treatment approach within this population. In addition, this study seeks to explore predictors of treatment outcome so as to inform the further development of this integrated intervention. The study will also include a pilot placebo-controlled trial of sertraline for those young people who fail to or only partially respond to the CBT intervention, so as to determine whether adjunctive anti-depressant treatment improves clinical response in this population. The relationship between genetic variants of the 5-HTT and treatment response to both the CBT arm and SSRI treatment will also be explored.