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This project is associated with a similar correspondence-based treatment for alcohol misuse co-morbid with depression. It is a randomised controlled trial, in which participants are assigned to standard care by their GP or, standard care plus correspondence-based treatment. After three months, those in the standard care only group are provided the same treatment as the experimental group. The correspondence-based treatment is founded on empirically supported cognitive behaviour therapy for alcohol misuse and comprises four weekly and four fortnightly letters covering topics such as motivation enhancement, goal setting, dealing with urges, planning for high risk situations and relapse prevention.

The purpose of the study is: Find out if patients receiving sorafenib will live longer. Find out if sorafenib has any effect on patient reported outcomes. Find out if sorafenib prevents the growth of or shrinks liver tumors and/or their metastases. Determine the pharmacokinetics (PK) in patients with liver cancer.

The primary purpose is to determine whether growth hormone and androgens alter protein metabolism in a way that will reduce protein loss in long-term glucocorticoid users. If so they may be a potential therapy to reduce the skin thinning and muscle weakness that occurs during longterm glucocorticoid use.

Bay of Plenty DHB is one of five District Health Boards currently trialling the use of a new assessment tool, the Minimum Data Set-Home Care (MDS-HC). The MDS-HC is used to determine the level of need and services required for older people (65+) living in the community. In conjunction with a well-executed care plan, the use of the MDS-HC is expected to improve the quality of care that DHBs can provide. DHBs across the country need information on the best way to implement the tool and this study is the first step towards providing the information and evidence for national implementation, should it prove to be beneficial in the medium to long-term. 320 older people who are referred for assessment through Support Net will be recruited to take part, half will receive standard NASC assessment whereas the other half will receive the MDS-HC assessment. Interviews with the older people will occur at baseline before the assessment and at one, four months and twelve month follow-up. Comparisons will include functional and social measures, cost of services as well as the differences in care plans and services recommended between the two assessment systems.