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One important clinical challenge in older individuals is maintaining mobility in the absence of pain. Peripheral arterial disease affects up to 12% of adults over 50 and impairs quality of life due to intermittent claudication causing pain and limiting mobility. Conventional therapies have only modest effect in improving symptoms. We hypothesise that angiotensin converting enzyme inhibition (with ramipril), which causes arterial vasodilation, also improves clinical symptoms in patients with peripheral arterial disease.

Chronic rotator cuff pathology is a musculoskeletal disorder of the shoulder often characterised by pain and weakness. It involves a specific group of muscles in the shoulder, which become damaged over time leading to a chronic loss of full shoulder function and the subsequent loss of quality of life for sufferers. There are few studies comparing the shoulder function of individuals with and without the condition and this is important to help us understand why the condition develops and what treatments might be more effective. Physiotherapy is often used to improve lost shoulder function. Physiotherapists use techniques that aim to reduce pain and weakness of the shoulder, thereby improving function. However there are very few studies that actually evaluate the effectiveness of physiotherapy for this condition. The purpose of this project is to evaluate whether physiotherapy intervention, using current accepted techniques, is effective in reducing pain and stiffness and improving strength and shoulder function. Previous experience has shown that the benefits of physiotherapy have not been properly evaluated by good quality research, and we would like to investigate whether or not physiotherapy is a useful intervention for this condition.

This study will clarify the effectiveness of prism adaptation treatment for stroke patients with hemi-spatial neglect. The treatment group will undergo five training sessions while wearing prism glasses. The control group will undergo the same procedure while wearing sham glasses. The two groups will be compared for improvements in the neglect impairment and in functional abilities.

This trial aims to assess the efficacy of antibiotics in treating children with a prolonged wet cough.

Raloxifene is a member of a family of compounds called selective estrogen receptor modulators (SERMS) that exert many of the beneficial effects of estrogen replacement without the associated increase in risk of breast and uterine cancer. Growth hormone (GH) replacement is beneficial in adults with hypopituitarism. Most GH deficient women also require oestrogen replacement. Oral oestrogens antagonise GH action at the liver, thereby reducing its beneficial effects on body composition and metabolism. The aim of this study is to investigate whether SERMs exert less of a negative influence on the effects of GH replacement, and therefore would be superior to conventional estrogen replacement in this setting.