ANZCTR search results

Objectives: To determine if changes in motor performance following a course of exercise in patients with mechanical neck pain (MNP) were dependent on the primary behavioral demand of the exercise performed. Design: Randomised clinical trial Setting: University laboratory. Participants: Sixty volunteers with chronic MNP were randomly allocated into either an endurance training group (ETr) (n=20), a coordination training group (CTr) (n=20), or an active mobility training group (MTr) (n = 20). Intervention: Exercise targeted to improve cervical motor performance Main Outcome Measures: Changes in cervical motor performance (strength, endurance, coordination, active mobility) following the training program were evaluated immediately following the 10 week training program, and at a 26 week follow-up. Results: Between group comparisons revealed significantly greater gains in endurance (P = 0.01) by the ETr group, and significantly greater gains in coordination (P = 0.02) by the CTr group. All three groups experienced improvement in pain (P < 0.05) and disability (P < 0.01). Conclusions: Changes in motor performance in individuals with MNP in response to an exercise program were dependent on the specific mode of exercise performed, with minimal improvement in other domains of motor performance

1. To investigate the effect of HIV infection and treatment with highly active antiretroviral therapy on individual steps of reverse cholesterol transport and vascular function. 2. To investigate the effect of HIV infection and anti-HIV drugs on intracellular cholesterol metabolism.

Surviving infants < 30 weeks' gestational age will be randomly alloacted to a developmental care package delivered in the home or to standard follow-up care over the first year of life. The major endpoint is the Mental Developmental Index on the Bayley Scales of Infant Devlopment at 2 years of age, corrected for prematurity

Drug hypersensitivity reactions mediated by T cells are increased in HIV infection and particular HLA types have been associated with reactions to the antiretroviral drugs Abacavir [HLA-B*5701] and Nevirapine [HLA-DRB1*0101]. B57 strongly predicts reactions with Abacavir probably via a direct effect of the drug on dendritic cell activation. Abacavir naïve subjects with B57 can also generate immunological response during in vitro culture suggesting a high precursor frequency for abacavir specific T cells responses. This project aims to determine how these drugs lead to hypersensitivity reactions and to define the genetic and immunological factors that can be used to predict reactions.

The purpose of the study is to compare the effectiveness of two treatment regimens in clearing the Hepatitis C Virus in patients infected with Hepatitis C genotype 1. The study aims to determine whether a higher dose of pegylated interferon given in combination with ribavirin for the first 12 weeks of therapy results in a higher rate of viral clearance and whether it is safe and tolerable.