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SNAC Trial
Expand descriptionThere are 32 active sites.
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The effect of Obstructive Sleep Apnoea (OSA) and its treatment with Continuous Positive Airways Pressure (CPAP) on arterial stiffness.
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IBCSG 22-00 Maintenance Chemotherapy in Hormone Non-Responsive Breast Cancer
Expand descriptionThis study aims to evaluate the efficacy of maintenance chemotherapy in women with hormone non-responsive breast cancer. Who is it for? You may be eligible join this study if you are a woman with receptor-negative primary breast cancer and are in adequate health to begin or continue with induction chemotherapy. Trial details Participants in this trial will be randomly (by chance) allocated to one of two groups. Participants in one group will undergo induction chemotherapy followed by maintenance chemotherapy. Maintenance chemotherapy involves taking one 50mg cyclophosphamide tablet daily for one year and two 2.5mg methotrexate tablets twice a day on days 1 and 2 of every week for one year. Participants in the other group will undergo induction chemotherapy only. This will be administered at the doctor's discretion. Participants will be regularly assessed over the duration of the trial to determine whether maintenance chemotherapy delays tumor recurrence and prolongs survival.
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The effect of a physiotherapy assessment of work capacity and return to work needs for people with chronic neck and back pain.
Expand descriptionThe proposed project addresses the major problem of chronic disability caused by occupational back pain and its escalating associated costs. This is a randomised, assessor blinded two-arm trial that tests the efficacy of the provision of evidence-based information regarding barriers to return to work and injury management recommendations to the treating doctor and insurer case managers, in reducing the number of sick days lost for workers with back pain when compared to usual care.
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BNP in SOB
Expand descriptionTo evaluate whether testing levels of BNP in patients presenting with shortness of breath has an impact on the management of these patients in the emergency department
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The effect of manual chest physiotherapy, positive expiratory pressure (PEP), and oscillating PEP on mucociliary clearance in subjects with CF
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Effect of Positive Expiratory Pressure (PEP) Physiotherapy on the Duration of the Exacerbation-Free Period in People with Cystic Fibrosis (CF)
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Continuous infusion of local anaesthetic in the control of pain following colorectal surgery
Expand descriptionTo determine if there is a better and safer option for pain relief following laparotomies for colorectal surgery, by using a continuous infusion of local anaesthetic into the wound.
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A randomised controlled trial to evaluate task-related exercise classes for older people with impaired mobility
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The impact of Sleep Disorders on motor vehicle accidents
Expand descriptionTo ascertain the prevalence of sleep disorders in drivers admitted to hsopital as a result of a motor vehicle accident.