ANZCTR search results

This study aims to adapt a specific Tai Chi program for a regional Australian community to determine if it is a feasible and helpful way to manage symptoms of fatigue, sleep disturbance, and depression in breast cancer survivors. Who is it for? You may be eligible for this study if you are a female aged 18 or older, completed chemotherapy for Stage 1, 2, or 3 breast cancer within the last three years and are currently experiencing moderate levels of tiredness, sleep problems, and low mood. Study details: Participants will attend a weekly, one-hour Tai Chi class (the "Easy 8 Form Yang Style") for a total of 8 weeks. All participants in this study will receive the Tai Chi training. Participants will complete assessments to monitor their symptoms at the start of the study, at the end of the 8-week program, and again four weeks later. It is hoped this research will determine if this Tai Chi program is an acceptable and effective therapy to help improve the well-being and symptom recovery of Australian breast cancer survivors.

Low-calorie sweeteners (LCS) have been widely used in food and beverages in recent decades. However, a recent World Health Organisation (WHO) report highlighted that people who consume LCS regularly have an increased risk of developing type 2 diabetes (T2D). Acesulfame potassium (Ace-K) is a widely used low-calorie sweetener that is absorbed from the gut and excreted in the urine. We want to find out whether Ace-K consumption reduces the amount of glucose excreted in the urine in pre-diabetes humans.

The study will compare blood levels of vardenafil between SDS089, a new nasal spray and tablets. In Part A each participant will receive a single dose of SDS089 2.5 mg, SDS089 5 mg and vardenafil tablet 20 mg with a 3-day washout period between dosing. In Part B each participant will receive a daily dose of SDS089 5 mg for five days. Participants will be confined in the clinical trial unit for the duration of the study (15 days).

Indigenous South Australians carry a disproportionate burden of dental diseases, with approximately 80 percent of Indigenous adults having both periodontal disease and dental caries. Poor oral health has profound impacts on both quality of life and social and emotional wellbeing. The chronic inflammatory nature of many dental conditions (for example, periodontal disease) mean there are widespread systemic impacts, including type 2 diabetes, chronic kidney disease and cardiovascular disease. Evidence suggests there are barriers experienced by Indigenous South Australians in accessing timely and culturally safe dental care. This application seeks to address these concerns by: (a) eliciting the views of Indigenous South Australians regarding their perspectives of what comprises culturally safe dental care, (b) providing such dental care and, (c) ascertaining the improvements in both oral and general health following receipt of timely, comprehensive and culturally safe dental care, with point-of-care testing used to assess changes in general health biomarkers following the dental intervention.

Polycystic Ovary Syndrome (PCOS) is a common but complex condition that is often delayed or difficult to diagnose. This study aims to understand how General Practitioners (GPs) in the Metropolitan Brisbane South and Logan regions currently diagnose and manage PCOS. The primary purpose is to assess GPs' knowledge of the latest 2023 International Guidelines, their current clinical practices, and the barriers they face, such as lack of time, software issues, or confidence when diagnosing the condition . Hypothesis: The study predicts that GPs who are aware of the 2023 International Guidelines will be more likely to use the recommended "simplified" diagnostic pathway (which avoids unnecessary ultrasound scans for certain patients) compared to those who are unaware of the guidelines. Method: Eligible GPs will be invited to complete an anonymous 15-minute online survey. The results will be used to develop better educational resources and support tools to help doctors diagnose PCOS more effectively.

This study aims to test a new automated device that delivers antibiotics gradually before surgery. The device, called IRIS, gives multiple smaller doses over 30 minutes, rather than one large dose, to reduce the risk of severe allergic reactions. We hypothesize that IRIS will both lower the chance of serious allergic events and still ensure patients receive enough antibiotic protection before surgery starts. By checking how easy IRIS is to use and whether it can safely administer the entire dose on time, we hope to show it can improve patient safety. If successful, this approach could make pre-operative antibiotic administration safer and more reliable in the future.

A new guideline was introduced in participating sites to exclude pulmonary embolism (PE) without the need for advanced imaging studies (computerised tomography pulmonary angiography or ventilation perfusion scans). This guideline involved accepting a higher threshold of a particular blood test (D-dimer) to rule out PE. Patients were contacted after 90 days post presentation to ask if they had been diagnosed with a PE or a deep vein thrombosis (which gives arise to PE).

This study aims to find a simple and reliable way to identify which patients with rectal bleeding need an urgent colonoscopy. Rectal bleeding can be caused by bowel cancer or other conditions like haemorrhoids, and delays in diagnosis can occur because the symptom is not specific to cancer. Who is it for? You may be eligible for this study if you are aged 18 years and over who have been referred by their GP for rectal bleeding and are on a waiting list for an outpatient clinic appointment. Study details Participants who are eligible will be asked to complete 2 tests: A two-sample home stool test (similar to the one used in the national bowel cancer screening program). A blood test that looks for cancer-related changes in DNA. Participants will collect two stool samples at home and attend a study site for a blood sample. The stool sample will be tested for haemoglobin, and the blood sample will be tested for DNA methylation changes. All participants will also complete short health and wellbeing questionnaires at the time of testing and after their colonoscopy. If either test is positive, the participant will be offered an earlier colonoscopy. If both tests are negative, they will remain on the usual waiting list (standard care). This research hopes to improve how patients with rectal bleeding are prioritised for colonoscopy, helping to detect bowel cancer earlier and reduce waiting times for those at higher risk.

This study aims to evaluate a new fully automated insulin delivery system, the Novel Medtronic Experimental Automated Insulin Delivery System, NMX7-AID, which adjusts insulin based on continuous glucose monitoring with minimal user input. Unlike the current MiniMed™ 780G system, the NMX7-AID aims to eliminate the need for users to deliver meal-time boluses. In this study we will test the safety and performance of the NMX7-AID system in real-life situations, including physical activity. This trial will enrol 24 adults with type 1 diabetes to use the system under a standardised protocol. As part of the study, participants will complete eight exercise sessions of varying intensity to test how the system responds during and post-exercise .

INNA-051 is being developed to prevent or minimise illness from viral respiratory infections like the common cold, flu or COVID-19. The study is being performed in adults aged 18 to 45 years inclusive to assess the safety, tolerability and effects of INNA-051 dry powder administered intranasally by two systems (single use and multi-use) on Day 1 and Day 8 differing by treatment sequence in cohort 1 and cohort 2, and to understand participants’ experiences with each.