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Endometriosis is a common inflammatory condition affecting women during their reproductive years, with potentially debilitating sequelae in the form of subfertility and chronic pain. Endometriomas are common, occurring in up to 44% of endometriosis cases. Surgical cyst excision is the mainstay treatment for endometriomas, however surgery is often detrimental to ovarian reserve. Conventional technique using manual stripping of endometriotic cyst from the ovarian cortex is commonly associated with inadvertent removal of healthy ovarian tissue. Therefore, current standard surgical treatment of endometriomas carries the caveat of further contributing to the fertility burden of patients, in whom ovarian reserve might already be compromised. A surgical technique using vasopressin has been shown to result in reduction in the need for bipolar diathermy in several small studies. This promising benefit of VIT also appeared to improve post-surgery ovarian reserve in one study. However, the data on the proposed benefits of this technique remains limited in the literature. Therefore, given the clear need for a less damaging surgical approach than standard approaches and the dearth in the literature of evidence of the efficacy of the use of vasopressin for the excision of endometrioma, we seek to elucidate the purported usefulness of this technique for the treatment of endometrioma and its potential benefit on ovarian reserve and endometriosis-related quality of life.

There is overwhelming evidence that adverse social and economic conditions have a negative impact on the health, welfare and development of children. Poor education, unemployment, financial and food insecurity and housing instability are linked with poor nutrition, developmental problems, increased risk of dysfunctional psychosocial behaviour and short- and long-term diseases of childhood and into adulthood. The American Academy of Pediatrics recommends that healthcare providers should routinely screen for and adopt interventions that address social risks as a mandatory aspect of healthcare. Innovative multidisciplinary team-based approaches are critical in hospital systems to identify social risk factors, and to refer families with unmet needs to community-based resources. The Lyell McEwin Hospital is the principal tertiary hospital serving a substantially disadvantaged community, with several suburbs in its catchment having significant relative disadvantage across a number of indicators. Australian Bureau of Statistics data show that families living in this catchment area have poorer educational achievement, greater unemployment, lower income and greater mortgage or rental stress compared with other areas. This is a 2-arm randomised control trial that will test electronic collection of a new social needs screening tool that will be adminstered either face-to-face with a health worker/researcher or be self-completed. The study will be conducted at the Lyell McEwin Hospital. The proposed study population includes adult parents/legal guardian(s) of children aged 0-5 years admitted to the Children’s Ward. Currently, there is no screening tool used in the Children’s Ward to identify social needs of families and this study will help determine the acceptability and feasibility of implementing such a tool.

The earlier KARVIAH Project recruited (n= 105) participants who took either curcumin or placebo orally for a period of 12 months. Participants were between the ages of 65-90 years living in retirement living accommodation or similar. Each participant undertook a health review, including general demographics, age, education, health and medication history and vital signs. During the study a comprehensive cognitive assessment was taken, blood drawn, lifestyle questionnaires completed (exercise, nutrition and sleep quality), as well as cerebral Magnetic Resonance Imaging (MRI); amyloid beta positron emission tomography (Aß- PET) and fluorodeoxyglucose (FDG-PET), The KARVIAH_XTND study will investigate biomarkers and longitudinal quality of life measure post curcumin intervention, as well as non-modifiable and modifiable lifestyle and health risk factors which may influence cognitive function.

The purpose of this study is to assess the safety and tolerability of GBT021601, as well as the pharmacokinetics (PK- how your body uses the drug) and whether ingesting food has an effect on how your body uses the drug. GBT021601 will be tested in 124 healthy participants aged 18 to 55 years. In Part A 64 participants will be administered a single dose of GBT021601 as oral tablets or capsules and followed up for 98 days for safety and PK assessments.

The first five years of life is an important period for establishing children’s liking and intake of vegetables. About half of Australian children aged 2-5 years attend formal early childhood education and care, where they consume 40-60% of their daily food intake. Therefore, early care and education settings can play a pivotal role in shaping young children’s dietary intake and there is a need to better support early care settings to provide supportive environments for promoting vegetable intake. The aim of this study is to evaluate to effectiveness of a multi-component initiative package for increasing children’s vegetable intake in long day care. The multi-component initiative package will comprise initiatives developed and tested in an earlier study, which support cooks to provide more vegetables on the menu, provide training for educators to encourage children to taste and enjoy vegetables at mealtimes, and support educators to teach a sensory and experiential vegetable-focused curriculum.

Anxiety disorders affect up to 40% of children on the autism spectrum, with many more showing sub-clinical levels of elevated anxiety. As anxiety can negatively impact many areas of a person’s life, including well-being and academic performance, it is important to develop ways to minimise its occurrence. One such intervention targeting anxiety is the Cool Little Kids group parenting program. Although originally developed for typically developing pre-schoolers, this intervention has shown promise in reducing anxiety in children on the autism spectrum. To better tailor this program for this population, the intervention has been modified to incorporate topics pertinent to anxiety in autism, specifically the intolerance of uncertainty. This study aims to determine the efficacy of this modified Cool Little Kids program on the reduction (or prevention) of anxiety in young children with autism (4- to 5-years-old). It is predicted that parental participation in this program will be associated with a reduction (or prevention) in their child’s anxiety level.

Within Australia, suspected cardiac chest pain represents nearly 1 million emergency department (ED) presentations every year. Most patients are eventually not diagnosed with acute coronary syndromes (ACS). Further, the clinical work-up of patients with suspected ACS is laborious and complex, often leading to unnecessary invasive tests. In an effort to improve decision-making, and thereby reduce unnecessary risk to patients and associated health-economic impacts, this study will elucidate the pivotal role of artificial intelligence (AI) as an aid in ACS diagnosis. This study will implement and evaluate the system-level intervention of AI-based decision support for clinical assessment of suspected cardiac chest pain in the reduction of death, myocardial infarction and 12-month readmissions. Further, the study will also provide the cost-effectiveness of embedding AI-based decision support in routine clinical assessment of suspected chest-pain and ACS.

This research aims to explore the relationships between mood, fatigue and physical activity through the use of a novel mobile application (ecological momentary assessment (mEMA)). mEMA is a survey method that allows data collection of participants’ behaviours, mood and perceptual experiences in real-time (momentary) and in real-life environments (ecological). Patients receiving peritoneal dialysis will be recruited from within the CNARTS catchment. This will be a intensive longitudinal observation design. Consenting participants will be met at home or during a routine clinical appointment to assist with download of the mobile app (free to participants) and instruction on correct use of this application. The application will prompt users to answer a set of pre-set questions relating to mood, fatigue at five times each day for seven days. Participants will also be asked to wear a accelerometer for the same seven day period. Accelerometers are highly valid and an objective measure of physical activity levels. The overarching research aims are to explore in real-time how fatigue levels fluctuate throughout the day, and to investigate the associations between mood and physical activity levels and fatigue in people with ESKD receiving peritoneal dialysis. The secondary aim is to explore the feasibility of using EMA in this population

The primary objective is to investigate what modifiable physical factors contribute to physical functioning in patients receiving peritoneal dialysis (PD). This 12 month longitudinal cohort study will assess physical activity levels / sedentary behaviour, muscle strength and cardiorespiratory fitness as predictors of physical function at three time points (baseline, six months and twelve months) in PD patients. Physical activity, sedentary behaviour, muscular strength and cardiorespiratory fitness have all been demonstrated as modifiable physical factors that can be positively modified through exercise based interventions. However, to best inform exercise prescription, understanding of the modifiable physical factors that contribute to physical function is required. This research project will be the first to determine the specific modifiable (physical activity and physical impairment) predictors of physical functioning in patients receiving PD. This project could significantly expand knowledge in this field, inform clinical practice and surveillance testing to improve early risk detection, and lead to future PD-specific exercise based interventions targeting physical functioning, improved quality of life and clinical outcomes.

One of the core strategies of Fire and Rescue NSW (FRNSW) is to protect the health and wellbeing of their workforce. To ensure this safety, various operational procedures are implemented for fire-fighting scenarios. One of these instances is the physiological and cognitive recovery of firefighters from a hot or hazardous event. Therefore, the aim of this research is to assess the effect of various recovery strategies on the performance of physical, perceptual and cognitive tasks following stressful fire-fighting tasks in the heat. . Collectively, this project will further both academic and industry knowledge of the optimum recovery procedures required for a variety of fire-fighting scenarios to optimise health for our states’ emergency services.