ANZCTR search results

This observational study aims to investigate the supportive care needs of melanoma patients across different stages of the disease, as well as their caregivers. Who is it for? Patients- You may be eligible for this study if you are aged 18 years or older, have been diagnosed with melanoma (Stage I-IV), and are either currently undergoing treatment (including chemotherapy, immunotherapy, targeted therapy. radiation therapy or surgery), or have completed treatment within the last two years. Carers- You may be eligible for this study if you are aged 18 years or older, and you are carer to a person diagnosed with melanoma (stage I-IV) who is currently undergoing treatment for their melanoma, or you are a carer to a person diagnosed with melanoma (stage I-IV) who has completed treatment for their melanoma within the last 2 years. Study details All participants (patients and carers) enrolled in this observational study will be asked to complete an online questionnaires asking them about their supportive care needs. It is anticipated that completion of the questionnaires will take about 35 minutes. Following this questionnaire, you will have an opportunity to provide your contact details to be contacted to participate in a semi-structured one-on-one interview with a member of the research team to further discuss their supportive care needs and preferences for future care. It is anticipated that the interview will take 30-60 minutes to complete. It is hoped this research will provide further information regarding areas of concern for melanoma patients and their carers, and that these details will help clinicians to design and provide more useful support systems for melanoma patients in the future.

This study aims to evaluate the feasibility and acceptability of a telehealth brief behavioural sleep program (Sleeping sound) in reducing children's sleep problems and emotional behavioural disturbance and parents mental health and quality of life in a sample of primary school aged autistic children with sleep problems.

Interventions to manipulate the plasma tryptophan/large neutral amino acids (LNAA) ratio have resulted in conflicting outcomes in relation to appetite, memory and mood. Evaluating the effects of changes in the tryptophan/LNAA ratio, in a standardised fashion, by acute administration of tryptophan and leucine, and across a range of ratios, may shed light on some of these apparent contradictions. Therefore, the aim of our study is to investigate the effects of changes in the plasma tryptophan/LNAA ratio in a standardised fashion, achieved by intraduodenal administration of tryptophan in combination with increasing loads of the LNAA, leucine, on GI functions, associated with appetite regulation, i.e. antropyloroduodenal motility and gut hormone release, and on appetite and energy intake, as well as on cognitive function and mood, in healthy lean individuals.

Anxiety and alcohol use disorders are among the leading causes of burden of disease worldwide, and they often co-occur. In recent years, innovative brain training procedures, known as Cognitive Bias Modification, have been developed to target implicit (i.e. subconscious) mental habits that contribute to the development and maintenance of anxiety and alcohol use disorders. Two of the most common types of Cognitive Bias Modification programs are i) Approach Bias Modification (ApBM) programs, which aim to re-train the implicit tendency to approach (rather than avoid) alcohol, and ii) Interpretation Bias Modification (IBM) programs, which aim to re-train the automatic tendency to analyse ambiguous information in a negative or catastrophic way. Given the interconnections between anxiety and alcohol use problems, a promising avenue that has not been explored is the potential of combining these effective cognitive re-training protocols to optimize standard treatments among younger comorbid samples. This project aims to pilot trial the feasibility, acceptability and preliminary efficacy of a 10-session ApBM+IBM intervention (‘Re-Train Your Brain’, delivered via the internet in one of two formats), when added as an add-on to treatment as usual, compared to treatment as usual only. The sample will be comprised of 90 young people aged 18-30 years with social anxiety and alcohol use problems. Outcomes will be assessed at baseline, 6-weeks post-baseline and 3-months post-baseline. It is hypothesised that the program will be deemed feasible, acceptable and show signs of preliminary efficacy.

Most athletes, at some stage in their career, will experience a problem with their sleep. Numerous situations are thought to contribute to poor sleep, including travel to competition, sleeping away from the home environment, and demanding training schedules. However, the single most common sleep complaint reported by athletes is difficulty falling asleep on the night before, and the night after, competition. Anecdotally, many athletes use sleeping tablets to overcome the difficulties of sleep on nights before/after competition. Sleeping tablets shorten how long it takes a person to fall asleep and also increases total sleeping time, but their use in athletes is problematic because of carryover effects of the drug on performance the next day. Surprisingly, very little is known about the effects of these medications on the response to exercise the following morning. This is an important issue as the use of sleeping medication in this special population may be counterproductive; that is, administration of the medication may help sleep on the nights before and after competition, but the carryover effects of the drug may significantly impair an athlete’s ability to train and/or compete the following day. This aim of this study is to examine the impact of two common sleeping medications (temazepam and zolpidem tartrate) on the physiological response to exercise in 18 male, well-trained athletes. Athletes will receive a standard dose of temazepam (10 mg as per the manufacturer's guidelines), zolpidem tartrate (10 mg as per the manufacturer's guidelines), or placebo 30 min before bedtime. Exercise performance (a time trial on a cycle ergometer) will be examined in the morning following administration of temazepam, zolpidem tartrate or placebo. Participants will complete all trails in a randomised order with a 7day washout period between each condition.

Robot assisted knee arthroplasty is a relatively recent development intended to assist the surgeons in achieving accurate bone cuts and predictable implant positioning. This study is investigating the accuracy of robotic surgery in partial knee arthroplasty. This will include the assessment of the intraoperative planned vs. actual component positioning. Also investigated will be the evaluation of safety and efficacy of this system including the assessment of common adverse events, physical exam findings, radiologic results and patient reported outcome measures.

A growing body of literature emphasises the potential benefits of self-compassion as a new approach to improve the outcomes of nutrition programs by addressing psychological factors such as emotional eating. Online technologies that comprise goal-setting and self-monitoring have also shown promise in increasing healthy dietary behaviours. Therefore, this randomised controlled trial aims to examine the efficacy of an online 12-week intervention that combined self-compassion with goal-setting and self-monitoring to improve dietary habits in people with overweight or obesity compared to the control group.

This research will explore the immediate, medium and long-term impacts of COVID-19 on rural and regional health care workers and the communities in which they live. A cohort of Loddon Mallee healthcare workers (COVID-19+/COVID-19-) will be recruited and followed over three years to examine the effects of the COVID-19 pandemic on the health and wellbeing of these workers. The main aims of the study are to: • Use a longitudinal study design to explore and describe the health and wellbeing impacts of the COVID-19 pandemic among the rural/regional healthcare worker cohort and sub-cohorts. • Identify protective/resilience factors, at the individual, organisation and community level that predict better physical and mental health outcomes for health workers. Evidence-based resilience interventions may then be implemented in the future to improve the workforce response to major disruptions such as the COVID-19 pandemic. • Inform policy options to support our rural/regional health care workers in responding to major disruptions such as the COVID-19 pandemic.

Trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) has been widely taken up by anaesthetic and ear, nose and throat (ENT) departments worldwide for airway management. THRIVE is a technique that uses rapidly insufflated, heated and humidified oxygen administered via nasal cannula to maintain oxygenation during periods of apnoea. It is regularly used for ENT procedures, in particular microlaryngoscopy. It allows for maintenance of oxygenation and unobscured surgical field by anaesthetic endotracheal tubes. The mechanism by which THRIVE and other apnoeic techniques (such as low flow intra-tracheal oxygen insufflation) maintain oxygenation is well understood, i.e. bulk flow of oxygen from the upper airway to replace the volume of oxygen taken up from the alveoli. However, a concern with all apnoeic techniques is the rise of blood and tissue carbon dioxide (CO2) levels in the absence of ventilation. Much of the support for THRIVE has centred on claims that unlike other apnoeic techniques, it is effective at eliminating CO2.. Recently, however, a study (1) of THRIVE in ENT microlaryngoscopy patients has suggested that when arterial CO2 levels are measured, the rate of rise of CO2 is actually as much as would be expected with other apnoeic techniques. In our anaesthetic department, we have considerable experience of apneoic oxygenation by low flow intra-tracheal oxygen insufflation (Lo-Flo). An oxygen catheter is directly passed under vision using a laryngoscope through the glottic opening to sit at mid tracheal level. This is then attached to oxygen supply at 0.5-1L/min. Transcutaenous carbon dioxide (TcCO2) can be easily measured with a transcutaneous probe that attaches to the patient’s skin in a non painful, non invasive manner. It is applied a few minutes prior to the start of the procedure. This study would build on the previous departmental experience with apnoeic oxygenation research. We plan to compare the two techniques of apnoeic oxygenation for ENT microlaryngoscopy, focusing particularly on the rate of rise of TcCO2. We believe it is likely that we will disprove the now widely held belief that CO2 rises less quickly with THRIVE than with other apnoeic techniques. (1) Gustafsson IM, Lodenius A, Tunelli J, Ullman J, Jonsson-Fagerlund M. Apnoeic oxygenation in adults under general anaesthesia using transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) – a physiological study. British Journal of Anaesthesia 2017; 118: 610–7

Total hip replacement is a common operation performed in Australia. A proportion of patients will transiently feel unable to get out of bed following this surgery due to dizziness, lightheadedness, blurred vision, nausea or low blood pressure. The medical term for this is orthostatic intolerance or orthostatic hypotension. The aim of this study is to administer a medication to investigate its effect on mobilisation after this operation.