ANZCTR search results

The present project is a feasibility study which aims to examine the effect of an 11-­week exercise intervention on the sleep of sedentary Australian pregnant women.

The primary aim of this study is to map the sensory distribution pattern and area of sensory overlap of the posterior antebrachial, medial antebrachial and lateral antebrachial cutaneous nerves (PABCN, MABCN, LABCN) of the forearm following an ultrasound-guided local anaesthetic block. The secondary aim is to map any sensory block that occurs in the hand. Results from the study will enhance our current understanding of the variability of cutaneous sensory innervation. It may clarify why some local anaesthetic nerve blocks do not produce the expected area of cutaneous sensory anaesthesia. It will benefit pain physicians when investigating and managing the cause of symptoms of injury to the cutaneous nerves of the forearm. Forearm flaps are often used by plastic surgeons to repair soft tissue defects. Sensory deficits often occur over the skin at the donor site. The results of this study will help with sensory matching when designing forearm flaps for reconstructive surgery

For quality assurance and research, this project aims to evaluate burn scar outcomes following treatment with the Lumenis® UltraPulse® Fractionated CO2 ablative laser at the Royal Adelaide Hospital (RAH). Similar laser therapy is currently available for the paediatric population in SA, however, until recently, there was no access to this treatment for adults in SA. As comparison burn units around Australia and internationally have been successfully using this therapy for over 4 years to improve patient outcomes without negative long-term effects, the RAH Adult Burn Service decided to investigate offering this modality as a scar management option for our patient population. As part of introducing this new procedure, we are interested in evaluating the outcomes to ensure there are meaningful clinical benefits for patients that complement our current scar management. We also aim to add to the research knowledge base by comparing subjective and objective scar properties and outcomes. And finally, we would like to also evaluate patient-reported outcomes and the effect on psycho-social well-being of both laser treated and non-laser treated scars.

We will conduct a two-centre randomised control study designed to assess the impact of transesophageal (TOE)- guided lead placement on the development of new or worsening tricuspid regurgitation (TR). All eligible patients will have a TOE at the time of randomisation, as an exclusion criteria is inadequate TOE images. In the treatment arm, the implanter will be guided by the images obtained on the TOE in order to place the lead in a favourable commissural position so as to minimise tricuspid regurgitation. In the control arm, the implanter will be blinded to the findings on TOE and use fluoroscopy to guide lead placement as is standard practice. The projected duration of the study is 2 years and it is expected that we will enrol 125 patients during this period who require the implantation of a pacemaker (PPM) or automated implantable cardioverter-defibrillator (AICD) as deemed clinically appropriate by their treating cardiologist. The follow-up to assess the primary and secondary endpoints after lead implantation will be at 6-months during a routine clinical follow-up with the treating specialist

The project's aim is to conduct a pilot randomised controlled trial to determine the efficacy of PATHFINDER on outcomes for heart failure with reduce ejection fraction over a 6-month period. Two hundred patients with CHF will be randomised to receive the PATHFINDER Heart Health Plan or control (usual care). For the PATHFINDER group, the project’s Nurse Practitioner (NP) will help facilitate the transition from tertiary to primary care including a Heart Health Plan, and be a point of contact for GPs needing support for medication titration. Referrals for cardiac rehabilitation program or exercise training program will be facilitated by the NP, with input from other Allied Health Professionals. Complex issues will be triaged for cardiologist support through the Advanced Heart Failure and Cardiac Transplant Service (FSH) . Primary outcome includes proportion of patients adhering to guideline-recommended treatment at 6 months post-enrolment. Secondary outcomes include proportion of patients receiving the guideline-recommended treatment independently at 6 months post-enrolment; exercise training program or cardiac rehabilitation program adherence by 6 month post-enrolment, 6 minute walk test distance, patient-reported outcome includes Kansas City Cardiomyopathy Questionnaire-short version (KCQ12), Patient Health Questionnaire (PHQ-2),Medication Compliance Questionnaire at baseline following enrolment and 6 month post-enrolment, ;PROMIS Physical Function Short Form 4a, Self-care of Heart Failure Index at 6 months post-enrolment.

We aim to evaluate the attitudes of mental health professionals towards MDMA-therapy trials by a comparison of attitudes to a neutrally-labelled pharmacotherapy, using a double-blind, randomised controlled vignette study design. We hypothesise that mental health professionals will have the following differences in attitudes towards MDMA-therapy, when compared a neutrally-labelled pharmacotherapy: 1) higher concerns for safety; 2) Lower predicted efficacy; 3) stronger objections to participation and/or lower levels of recommending participation. By assessing professional attitudes towards MDMA-therapy for PTSD using an experimental study, we can understand if there are any biases that may be inhibiting conducting research in this area, or inhibiting the uptake of this potential new treatment by clinicians.

All patients receive the POP device app as part of standard of care practices for under going Total Hip Arthroplasty procedures, irrespective if they are enrolled in the study. This is is a pilot, observational, prospective study to assess patient satisfaction of a mobile phone application (App) as a means of delivering information on post-operative treatment program, rehabilitation and research tools for patients undergoing total hip or knee replacement. Follow up of Patient Reported Outcome Measures (PROMs) is essential to auditing practice and undertaking research in arthroplasty. Traditionally, PROM data is collected via paperwork. Similarly, patient education about post-operative regimens has been in the form of verbal discussions and multiple sheets of paper. The Patient Optimised Pathway application (POP-App) has been designed to reduce this paperwork burden. It is hoped this app will improve the surgical patient journey. 30 participants will be enrolled into a single arm of the study (no control group). Participants will be shown how to use the app and fill out the PROMs prior to operation. They will then be asked to fill out PROMs and Patient Satisfaction surveys pre-operatively and at Day 1, 2 weeks, 6 weeks, 3 months and 6 months post-operatively. Data collected will confirm acceptability of the app.

It is important for individuals with type 1 diabetes (T1D) to engage in a physically active lifestyle, but it can be challenging to control blood glucose levels around exercise. Current exercise guidelines are not written for young people with T1D and are difficult to access. Our research team have developed a mobile health App called ‘acT1ve’. The app was developed in collaboration with young people with T1D, and enables users to receive personalised insulin and carbohydrate advice in relation to the exercise they plan to participate in. This advice is based on international T1D exercise guidelines. The aim of this study is to test the use of acT1ve in free-living conditions with young people with T1D.

Prominent treatments for post-traumatic stress (PTS) involve confronting the traumatic memory and associated thoughts, feelings and sensations. There is recent evidence to suggest that such treatment methods may not need be extensive and may be effective in a short-term intervention, such as structured writing. The proposed research aims to explore the effectiveness of two experimental writing paradigms in comparison to a control, for producing change in PTS symptoms. The research additionally aims to explore the factors that promote recovery (i.e. mechanisms of change). In particular, it will explore the role of each of four putative mechanisms: (1) changing learnt expectation of distress on recounting, (2) changing thinking about the event, (3) self-compassion, and (4) social sharing). It is hypothesised that the experimental conditions will produce change in PTS symptoms in comparison to the control; and that the factors which will account for these changes (i.e. mechanisms) will differ depending on type of writing condition and its associated underlying theoretical paradigm.

The advent of technology that can enable immersive and engaging, high-dose practice, has led to new opportunities for restoring function in neurological patients. ECU’s Neurorehabilitation and Robotics (Edwards) Lab has recently acquired the Mindpod motion capture and gaming system, that enables fun exploration and practice using whole arm-hand in large movements to guide a dolphin to swim in a gaming environment. We test if this immersive digital gaming system in the stable chronic phase of stroke, can safely and feasibly be conducted and can have positive effects on arm function and cognition.