ANZCTR search results

Prior research strongly suggests that the drug epoetin alfa improves the outcome of critically ill trauma patients. If proven correct, this has important implications for the management of trauma patients throughout the world.. We will conduct an international multi-centre trial in critically ill trauma patients that will determine the effect epoetin alfa on the rate of death and severe disability.

This study aims to identify if women with a diagnosis of endometriosis are using social media to gain health information, share stories and both provide and receive online support regarding endometriosis. It involves completion of a once-off questionnaire with questions relating to basic demographics, health information and social media use both in general and specifically related to endometriosis. We are recruiting women from the Royal Women's Hospital general gynaecology teams and aiming to have 100 participants. We hypothesise that a large proportion of our patients use social media as a self-management strategy for endometriosis.

Older adults admitted for acute care are extremely sedentary, more so for post-hip fracture patients. With the relationship between sedentary behaviour (SB) and poor outcomes, various interventions to reduce SB and increase physical activity (PA) is critical if older adults are to achieve some level of pre-fracture status post-hip fracture across all continuum of care. However, so far, it is not clear if providing coaching and real-time feedback to patients on their level of SB and PA will encourage them to take more action to reduce SB and increase PA during acute care and afterwards. Therefore, an individualised goal-setting intervention to break SB and increase PA while on admission in acute care post-hip fracture is important. This study will utilise health coaching and ActiGraph-based real-time feedback to break SB and increase PA while on admission and follow-up at 3, 6 and 12 weeks respectively to determine the effect of an intervention on SB, PA and other geriatric-specific outcomes in the long-term. Study Hypothesis: There will be no significant difference between intervention and control groups on sedentary behaviour and physical activity measures

Older drivers have relatively high crash rates and are increasing in number. We aim to evaluate the relative effectiveness and cost-efficiency of interventions for older drivers. A randomised control trial comparing driving lessons, personalised feedback on driving skill, and a group based road-rules refresher course will be conducted. If effective, interventions will improve driving safety, reduce costs associated with crashes, and maintain social participation.

This is an international research project to test the primary hypothesis that jockeys and riders who have been trained in fall safety skills will have reduced injury severity in falls. Participants will be assigned to training intervention or control groups and those assigned to the training intervention groups will undertake an 8.5 hour skills-based fall safety training program. Following a data collection period, participants who are assigned to the control groups will be offered the same fall safety training program. The training is based upon modified gymnastics skills, and all training will be directly supervised by Lindsay Nylund who is a former Olympic gymnast with qualifications in physical education, vocational training, advanced accreditation in gymnastics coaching.

The purpose of this study is to test the safety and tolerability of a potential breast cancer treatment called endoxifen. Who is it for? You may be eligible for this study if you are a healthy female aged 18-65. [***Please note participants who have cancer are not eligible for this study.***] Study details Participants in this study will receive tablets, to be taken by mouth and will be randomised (by chance) to either the active drug or a placebo. Neither the participant nor investigators will know who gets the active or placebo drug. Initially, only a single tablet will be taken. After checking the results of this first day, participants continue into the second part of the study where they will take their assigned tablet once a day for another 14 days. As part of this study, all participants will need to provide blood samples, urine samples, answer questionnaires and have a physical exam.

Purpose / Hypothesis: This study seeks to determine the level of blood ketone in patients who fast for surgery. We also examine various risk factors which potentially lead to high ketone levels, and try to establish relationship between these factors and the presence of high ketone level. Methods: Participants will have two very small blood samples taken, one immediately before and one immediately after surgery. The relationship between the risk factors and the ketone levels is analysed to determine how strongly each factor affects the ketone level. By improving our understanding of ketone levels in patients fasting for surgery, this study will improve the clinical care we deliver by improving how we detect and treat patients who develop high ketone levels.

Older people living in residential care facilities (RACFs) are some of the most vulnerable in society with increasingly complex health and personal care needs. Transfers to Emergency Departments and hospitalization are common. The Aged Care Emergency Program was developed to better support acutely unwell residents in RACFs. It is a multi-component service level intervention designed to support RACF staff in identifying and addressing medical needs with an aim to reduce unnecessary hospital admissions. Using a stepped wedge non-randomised cluster design, a large scale evaluation was made of the roll out of the program across a broad geographic area of Hunter New England local health district.

This study compared brief intervals of stair climbing to moderate-intensity walking and physical activity guidelines for adults with metabolic syndrome.

This study examines the difference between implanting a conventional pacemaker and a novel technique in pacemaker implantation where the pacing lead is implanted in the His-bundle and deep septal region of the heart. This novel technique could circumvent the known adverse effects of conventional pacemakers, and result in improved patient outcomes. Conduction system pacemaker is hypothesised to result in improved cardiac function compared to conventional pacemakers.