ANZCTR search results

Primary fixation of the acetabular cup in total hip arthroplasty is vital for long-term stability. In cementless press-fit cups, this initial stability is achieved by the press-fit fixation. Additional primary fixation may be obtained by the use of extra screws. However, the value of additional screw fixation of press-fit acetabular cup implants on implant survival is questioned. We investigate if screw fixation is necessary when a GB DMD uncemented cup purposefully designed to enhance osseointegration is implanted. The specific objectives of this project are to i) evaluate the migration profile of the GB DMD uncemented acetabular Cup at 3 months, 1 and 2 years ii) compare quality of stability (using radiostereometric analysis) and clinical outcomes with screw verses no screw fixation at 2 years

Protagonist Therapeutics, Inc. is developing PN-943 as a potential oral therapy for patients with ulcerative colitis (UC). This study will be conducted in 10 normal healthy volunteers who meet all of the inclusion criteria and none of the exclusion criteria. The study is to assess the multiple dose pharmacokinetics (PK) and pharmacodynamics (PD) of an oral immediate release (IR) tablet of PN-943 compared with an oral solution in healthy volunteers.

Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by recurrence, pleomorphic skin lesions, dry skin, and severe pruritus. In most countries worldwide, the prevalence of atopic dermatitis is 10%–20% in children and 2–8% in adults. At present, there is no curable treatment for atopic dermatitis. The goal of treatment is to relieve or eliminate clinical symptoms, recover skin lesions to the greatest extent, eliminate predisposing and/or aggravating factors, reduce and prevent relapses, and improve the quality of patients’ life. Therefore, identification of new effective and safe therapies is an important area of research.

The aim of this study is to evaluate the antioxidant and anti-inflammatory properties in healthy populations post-coloured rice consumption. Participants will have blood samples taken before & at set time points after rice consumption. The blood samples will be analysed for antioxidant and inflammation-related biomarkers. A one week washout period will be implemented for each participant for each variety tested. The intent of this study is to identify if coloured rice consumption has the ability to alleviate risk factors associated with the development of lifestyle diseases such as cardiovascular disease.

This is a detailed study of liver and muscle insulin resistance in adults with type 1 diabetes. The investigators will study the efficacy of adjunctive metformin in reversing insulin resistance and improve glucometabolic status, endothelial health and other parameters. Predictors of response to metformin will be assessed.

Novel methods of intervention delivery that factor in scalability, cost-effectiveness, and engagement of hard-to-reach populations are urgently needed to address concerns that fewer than 25% of people with eating disorder symptoms seek or receive treatment. Preliminary evidence indicates that interventions delivered via smartphone apps can effectively address eating disorder symptoms. However, randomized controlled trials of stand alone app-based smartphone interventions have yet to be conducted. The present RCT examines the efficacy of an app-based cognitive-behavioural intervention delivered via a smartphone on eating disorder symptoms. The hypothesis is: Participants allocated to the smartphone intervention will experience significantly greater reductions in eating disorder symptoms, quality of life impairment, and psychological distress at post-test (6 weeks from baseline) relative to participants allocated to the wait-list control.

Dietary restraint is one of the most potent risk factors for binge eating. Therefore, this study will examine whether dietary restraint can be addressed through a brief internet-based intervention. It is hypothesized that participants allocated to the online intervention will experience significantly greater reductions in binge eating behaviour and dietary restraint scores at post-test than participants allocated to the control group.

The OASIS project is a single-centred,randomised, prospective study of 85 children. Lung mechanics will be assessed using continuous forced oscillation technique (FOT). The aims are, in children undergoing general anaesthesia, to compare the effect on forced oscillations mechanics of: 1) two different recruitment strategies: repeated inflations vs. one sustained inflation to a high-pressure level, 2) administering them through a laryngeal mask vs a cuffed tracheal tube. We hypothesise that: (1) One sustained inflation is more effective than multiple manual breaths with high levels of inspiratory and expiratory pressure in recruiting the lung (2) Both recruitment strategies (sustained inflation or multiple manual breaths) are less effective when applied via laryngeal mask compared with an endotracheal tube. The results of this study will help paediatric anaesthetists to formulate new evidence-based guidelines and policies to optimize the ventilation strategy in children undergoing general anaesthesia. Additionally, successful implementation of continuous forced oscillation technique (FOT) measurements (assessment of respiratory mechanics) in the setting of different airway devices has the potential to change routine clinical practice by allowing anaesthetists to adapt ventilation to rapid changes in mechanics during anaesthesia which are particularly pronounced in young children.

Perinatal depression is highly prevalent (up to 20% of postnatal women experience depression meeting diagnostic criteria). The single largest barrier to treatment is the very low rate of initial identification, most cases go undetected (60% or more). Importantly, even when women are identified as depressed, only 10% receive adequate treatment. A major obstacle is that primary care professionals are generally time poor and lack simple integrated systems to assist them to not only detect depressed women, but also to make best-practice decisions about management. We have developed an electronic Clinical Decision Support System to guide health professionals (PIRIMID) to improve current practices through consistent, accurate and rapid assessment integrated with recommendations for pathways to care, based on NHMRC-endorsed Clinical Guidelines. Aim of This Study: To establish the effectiveness and cost-effectiveness of PIRIMID for identifying perinatal depression and facilitating treatment uptake compared to current practice.

The aim of this research is to develop a mobile based multidisciplinary virtual clinic based on the existing platform (MoTER) and to investigate the impact of such a clinic on health outcomes and clinical management of patients with HF. The primary hypothesis is that participants in the MoTER-HF arm will have satisfying uptake and adherence to the intervention. Patients in the MoTER-HF arm will have access to the mobile based intervention program which consists of educational materials, self-management interventions and healthcare providers' feedback for the period of three months.