ANZCTR search results

A randomized controlled trial will establish the extent of an increase in muscle mass and function during the novel liver-targeted testosterone therapy in older men and women with sarcopenia. We will combine this with progressive resistance training component in half of the patients to investigate independent and exercise-stimulated synergistic effects of resistance training and liver-targeted testosterone in improving muscle mass and function in sarcopenia.

This study aims to evaluate the safety, tolerability and signs of efficacy of a new investigational drug called tigilanol tiglate in participants with head and neck cancer. Who is it for? Patients may be eligible to join this study if aged 18 years or more and have been diagnosed with head and neck squamous cell carcinoma. Study details: All participants in this study will receive between one and three tigilanol tiglate injections directly into 1-4 tumours. Tigilanol tiglate may lead to breakdown of tumour blood vessels and recruitment and activation of white blood cells. This leads to rapid tumour cell death. This drug has previously been tested in humans (see QB46C-H01 - ACTRN12614000685617 and QB46C-H02 - ACTRN12614001207606). Participants will be monitored for at least 3 weeks following tigilanol tiglate injection in order to evaluate safety, tolerability, tumour response and pharmacokinetics (the action of the body on the drug). The results from this study will be analysed to see if it is worthwhile for this new drug to be tested in future studies involving larger numbers of cancer participants.

This pilot study aims to assess the feasibility and acceptability of conducting a pilot randomised control trial to evaluate using AllPlay Learn website and/or professional learning courses as a ‘professional learning intervention’ among educators in early childhood education and care settings (i.e. long day care centres and/or kindergartens) and teachers in primary school classrooms. We will use a feasibility and acceptability evaluation and will measure the effects of the intervention on educators’ and teachers’ self-reported competence and confidence, and children’s emotional regulation, conduct, attention, peer relations and pro-social skills (reported by educators, teachers and parents).

The purpose of this study was to ascertain whether adapting transdiagnostic-CBT to include intermittent MI outperforms transdiagnostic-CBT alone in anxiety disorder populations.

This is a Phase II RCT study that will explore the effects of orthotic intervention in addition to standard therapy on stiff post-traumatic elbows. The purpose of this 6-week trial is to establish the feasibility of proceeding to a larger definitive RCT. This study will also establish the reliability and validity of 2 clinical tools (Modified Weeks Test and Joint End Feel) that will evaluate elbow joint stiffness.

Returning to work after a stroke is an important rehabilitation milestone, and is associated with better physical and mental health outcomes. This study will pilot and evaluate feasibility of a return to work coordination service (known as RESET) that uses telecommunication to increase access to people who have had a stroke. The overall aim of this study is to test procedures and assessment measures that can be used in a full clinical trial of RESET, evaluating acceptability to participants, and satisfaction with the intervention.

Pulmonary Rehabilitation is recommended as a cost effective way of improving exercise capacity and quality of life for people with chronic obstructive pulmonary disease. In spite of the strong evidence for the effectiveness of pulmonary rehabilitation, many people are not referred and if they are referred they do not attend. We have developed and tested a series of three short patient education videos that address known barriers to patients attending pulmonary rehabilitation. These videos were piloted at Liverpool Hospital and we have subsequently been awarded funding from the Agency for Clinical Innovation to test their effectiveness. The aim of this multi-centre randomised controlled trial is to determine whether the use of the short videos delivered to people with chronic respiratory disease during a hospital admission increases the uptake of pulmonary rehabilitation.

This is a phase 1, single-center, randomized, double-blind, two-way crossover study comparing Abcertin and EU-sourced Cerezyme® in healthy volunteers between the ages of 18 and 45 years (inclusive). The purpose of this trial is to evaluate, characterize, and compare the pharmacokinetics, and short term safety and tolerability of single-dose intravenously administered Abcertin with EU sourced Cerezyme® in healthy volunteers.

The purpose of this study to enhance our understanding of the interactions between medications and the bacterial populations (which together comprise the microbiome) in the nose and sinuses. Our hypothesis is that both oral and topical steroids will differentially alter bacterial profiles in patients with CRS to influencing the clinical outcomes in patients. We will target patients in the pre-operative clinic presenting with symptoms consistent with a diagnosis of CRS. Patients who require medical management of their symptoms and consent to participate will be randomised to one of three groups, each of which consists of one of the standard treatment regimens for the pre-operative medical management of CRS (oral steroid or topical steroid or oral antibiotic).

The purpose of this study is to evaluate the effects of incorporating periodical rest periods within exercise sets to alleviate shortness of breath and improve psychosocial response to exercise in patients with advanced lung cancer. Who is it for? You may be eligible for this study if you are an adult who has advanced lung cancer ( stage IIIB-IV) Study details All participants in this study will receive 3 exercises targeting both the upper and lower body. Exercises will include leg press, seated row and chest press. There are two treatment conditions. One condition is the traditional set (TS) exercise, with no rests between repetitions. Participants will complete 10 repetitions in a row without rest. The other condition is the cluster set (CS) where participants will rest for 20 seconds after two repetitions until 10 repetitions are reached. Participants will complete 3 sets of exercise in both conditions and will wait at least 72 hours between the two conditions. Part of the study will involve questionnaires on shortness of breath and self confidence. It is hoped this study will identify a novel method of targeted exercise medicine that may alleviate shortness of breath and improve clinical outcomes in people with advanced lung cancer.