ANZCTR search results

The Risk Reduction for Dementia Initiative – North West (RReDI-NoW) will involve community members in 9 centres across northwest Tasmania to evaluate the Preventing Dementia massive open online course (PD MOOC) with or without additional community led dementia risk reduction initiatives. The effectiveness of the PD MOOC and community initiatives will be measured against providing written information about dementia risk reduction in a randomised controlled trial. The aims of the study are: • To examine the impact of the PD MOOC on dementia risk reduction knowledge, attitudes and behaviour, and risk states. • To examine whether engaging communities in dementia risk reduction initiatives has additional benefits above education through the MOOC alone. • To examine the sustainability of any improvements in dementia risk reduction knowledge, attitudes and behaviour, and risk states.

The main aim of the PAWalks study will be to examine the effectiveness of a technology-based dog-walking intervention for increasing daily physical activity (PA) of dog owners. The intervention is based on behaviour change theory and a commercially available wearable dog activity tracker (primary outcome: daily number of steps). The secondary objectives will be to examine if intervention-induced increases in PA are accompanied by improvements in sedentary behaviour (SB) and psychosocial health of owners (secondary outcomes: SB time, psychological distress, loneliness, positive affect, dog-ownership attributed social connections, dog-owner relationship), and frequency of canine behavioural problems.

Purpose of the study is to compare if orthopaedic patients with mild cognitive impairment who recieve computer based cognitive therapy have better changes in cognitive function, activities of daily living and overall rehabilitation outcomes when compared to patients receiving standard care. The secondary aim is evaluate the usability of computer based cognitive therapy for orthopedic patients in rehabilitation

In the 21st century there have been some significant advances in how we think about ‘health’ and about ‘family-centred services’. As a result, we are changing the ways we try to work with families to help them manage their children’s developmental disabilities. These ideas have been developed and ‘packaged’ – by a team of health services researchers, clinicians and parents – into a set of 5 weekly workshops for parents new to their journey as parents of children with long-term developmental disabilities. These workshops are collectively referred to as ENVISAGE: ENabling VISions And Growing Expectations. ENVISAGE aims to empower caregivers of children with disabilities to build self-efficacy, autonomy, and sense of competence; to increase their skills as parents of children with complicated lives; and to connect with other caregivers to improve parent and family outcomes. We hypothesize that the primary outcomes of ENVISAGE will be positive trends in the caregiver-reported outcomes of family empowerment and caregiver confidence.

Tonsillectomy is a very common surgery for children. Post-tonsillectomy there is a high rate of unplanned re-presentation to hospital with many of these visits due to pain. From recent work by our research team we know that despite being given pain medications on discharge, patients can experience insufficient pain management, perhaps in part due to misperceptions of parents regarding the safety of these analgesic medications. In this study we aim to assess the impact of honey on postoperative pain levels through a placebo-controlled trial. If honey is shown to be effective; then children will not only benefit from reduced pain but may also require less additional doses of strong pain killers. Furthermore, better pain control will reduce the number of re-presentations to their general practitioners or hospital benefiting the Health System as a whole.

The purpose of this study is to determine the safety and diagnostic value of 64Cu-Bombesin in PET/CT imaging in patients with progressive metastatic hormone positive (oestrogen/progesterone receptor positive) breast cancer. Who is it for? You may be eligible for this study if you are a female aged 18 or above with oestrogen/progesterone receptor positive metastatic breast cancer. Study details: Participants will undergo a variety of scans over the two study visits. There will be four types of imaging: a Cu64 Bombesin PET scan in addition to conventional imaging in the form of a bone scan, CT scan, 18-FDG PET scan. Prior to the injection of Cu64 Bombesin, patients will be subject to review of their haematological and coagulation assay, ECG and vitals. The patient’s vitals will be monitored before, during and after the scan. Where the scan reveals lesions amenable to biopsy, patients may optionally be recruited for this, and consent for this obtained separately. This will allow for further characterisation of receptors present on tissue samples. The outcome of this study will potentially have important implications for the staging of hormone positive metastatic breast cancer.

Insulin therapy is the most effective treatment for diabetes, however, one in four adults with type 2 diabetes (T2D) delay initiation due to negative attitudes towards insulin. Few evidence-based interventions exist to address these issues and none widely available in Australia. The aim of this study is to pilot-test the efficacy of a novel psycho-educational web-based resource for reducing negative attitudes to insulin among adults with non-insulin treated T2D. A two-armed pilot randomised controlled trial will be conducted to assess the feasibility and acceptability of the intervention content and format. Up to 40 adults with non-insulin treated T2D will be recruited through the ACBRD (and affiliated organisations) websites, e-newsletters/blogs and social media. Preliminary evidence for the effectiveness of the web-based resource (intervention) compared to widely available existing resources (control) in reducing negative attitudes towards insulin will also be investigated. Outcomes will be assessed at baseline and 2-week follow-up.

Introduction: Health-related quality of life (HRQoL) is a commonly used health outcome. For many acute conditions (e.g. fractures), retrospective measurement of HRQoL is necessary to establish pre-morbid health status. However, the validity of retrospective measurement of HRQoL following an intervening significant health event has not been established. The aim of this study was to test the validity of retrospective measurement (recall) of HRQoL by using a test-retest design to measure reliability and agreement between prospective and retrospective patient-reported HRQoL before and after an intervening health event (major elective orthopaedic surgery). Method: Participants were recruited from the pre-admission clinic of a metropolitan hospital. Participants were assessed for their HRQoL using the EQ-5D-5L at two time-points; prospectively at two weeks prior to their date of surgery and then retrospectively (recalling their pre-operative health) following elective hip or knee joint replacement surgery. Prospective measurements were compared with retrospective measurements for the five domain scores (nominal data) using intra-class correlation and for the EQ-Index score and the EQ-Visual Analogue Scale (VAS) score (continuous data), using Pearson’s correlation. Agreement was tested in the continuous variables using Lin’s coefficient of concordance (pc) and inspection of Bland-Altman plots.

This is FIH randomized, double-blind, placebo-controlled study in healthy population. Up to 7 single ascending doses (cohorts 1 to 7) will be studied to determine the safety and tolerability of ALD1910. Approximately 96 healthy male and female participants are planned for the study, 64 for Part A and 32 for Part B.

The aim of this quality improvement project is to implement and examine the effectiveness of strategies to support clinical staff in the provision of the preventive care policy within community mental health services in the Hunter New England LHD. An implementation intervention will be co-developed with the service to support clinicians to provide preventive care for tobacco smoking, harmful alcohol consumption, inadequate fruit and/or vegetable consumption, and inadequate physical activity. Evidence based strategies such as education and training, feedback reports, aids to enable care provision, and a designated support person will be tailored, specifically to overcome the impediments to preventive care provision in community mental health. It is hypothesised that clients from the intervention service will receive higher levels of preventive care compared to a control service who will receive no implementation intervention.