ANZCTR search results

The aim of this project is to collate feedback from patients with Multi Resistant Organisms relating to the perception of their care whilst an inpatient at QEII Jubilee Hospital. The findings will enable us to ascertain if the information currently provided is adequate and appropriate and delivered in a way that is meaningful and useable for the patients. This study will enable us to determine what/if any improvements that can made in our current management of patients with Multi Resistant Organisms.

The aim of this study is to report the effects of a 9 week Movement Oriented Games Based Assessment programme for 8-12 year olds for improving children's movement competence, physical activity, physical fitness, self-confidence and children's self-perceived enjoyment and motivation. This scaling trial will be used to establish an understanding of the effectiveness of MOGBA prior to roll out across activity programmes within Nike's Made to Play portfolio. We hypothesized that children in the MOGBA intervention, compared to those in the control group, will display more favorable changes in movement competence, physical activity, physical fitness, physical self-perceptions and game perceptions,

The symptoms of Allergic rhinitis, such as nasal congestion and itching, are a burden for an estimated 3.2 million Australians and its prevalence is increasing. There is growing evidence to suggest that probiotic supplementation elicits beneficial health effects on the host through modulation of the immune system and thereby can improve symptoms associated with Allergic rhinitis. The aim of this research is to examine the effect of probiotic supplementation on symptoms and quality of life in individuals suffering from Allergic rhinitis.

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that uses a momentary electromagnetic pulse to activate localised areas of brain tissue. A patterned form of TMS called Theta Burst Stimulation (TBS) appears to induce temporary plastic-like change in the brain. The technique has proven useful in treating disorders (e.g depression). However, individual response to TBS varies in neuroscience research and clinical treatment. Indeed approximately 40% of depression sufferers are not helped by TBS. Recent evidence suggests this variation may be due to TBS activating different groups of brain cells in different people, the latter of which can be measured using common TMS outcome metrics. Given mixed evidence, the proposed research will comprehensively examine the degree to which common TMS outcome metrics can predict TBS response. Investigating and controlling sources of variability in TBS could lead to greatly improved neuroscientific knowledge and clinical outcomes.

This study aims to conduct a pilot randomised trial at the Queensland Children’s Hospital with children with burn scars to determine the effectiveness of ablative fractional CO2 laser therapy or medical needling therapy for the treatment of thickened burn scars. Both the interventions of medical needling and ablative fractional CO2 laser are believed to improve scarring by creating microscopic holes in the scar tissue that assist to remodel the scarring. It is hypothesised that either medical needling or ablative fractional CO2 laser is more effective than usual care at improving children's outcomes. This trial will pave the way for a larger multi-centre randomised trial of the three included interventions in children.

Compared with the general population, people with dementia and cognitive impairment are almost twice as likely to present to emergency departments (EDs). For people with dementia a sudden change in environment to a busy ED with unfamiliar care providers, coupled with acute injury or illness, can cause rapid disorientation and decline in responsive behaviours. When responsive behaviours such as wandering, agitation and aggression occur in the ED, they are typically managed with restrictive interventions or one-on-one nursing care. However, chemical restraint in the form of psychoactive or sedating medications can lead to worsening symptoms or delirium. One-on-one nursing is expensive and often conducted by unskilled staff who have neither the knowledge nor the experience to provide therapeutic interventions. While non-pharmacological treatments to manage responsive behaviours have been proposed as the gold standard, especially in sub-acute and residential aged care settings the evidence about their effectiveness in EDs is scarce. In this study we will determine the effectiveness of a therapeutic activity kit in ED patients who exhibit or are at risk of developing responsive behaviours, on the need for one-on-one nursing and chemical or physical restraint.

The main objective of this study is to evaluate the safety and feasibility of the OcuDyne Ophthalmic Micro Balloon Angioplasty System in subjects with dry age-related macular degeneration (AMD). Currently there is no treatment available for dry AMD and this device system may offer a potentially effective treatment. The study is first in human and is a prospective, open label, feasibility clinical trial. This multi-center trial will be conducted at up to six sites in Australia and aims to enroll and treat up to 30 subjects. This study involves a 60 day screening period, study procedure, overnight observation, and follow-up visits (Day 2, Week 1, Week 4, Months 3, Months 6). The study duration for each participant is approximately 8 months. The feasibility of the procedure is presented due to the historically successful use of small artery cerebral angioplasty and ophthalmic artery (OA) angioplasty for acute ischemic retinopathy using like instrumentation. The OcuDyne #OC-1901 project is an effort to confirm the feasibility of establishing the presence of OA ostium narrowing intraoperatively and further, to establish the ability to treat the condition of dry AMD.

Healthcare providers may be vulnerable to psychological trauma in the aftermath of an adverse critical clinical incident, particularly if it is associated with a poor patient outcome. This may be especially evident amongst the medical fraternity, who often lead the management of the acutely deteriorating patient, and there is evidence of stress within this cohort in the literature, and the need for upstream preparation. This project will involve interviewing experienced intensive care doctors about adverse critical clinical incidents whereby patient management was potentially compromised secondary to human error. The aims of the interview will be to explore the impact of the events on them, in terms of their thoughts and feelings and also to explore the coping mechanisms they applied to enable them to emerge from the event with some deeper understanding and resolution. These personal recounts will be transcribed, reviewed and qualitatively analysed in order to identify common human factor gaps in clinical management during adverse critical clinical incidents, and the manner in which the personal effects of these events were mitigated. Results will inform the development of a framework of human factor training, possibly utilising simulation-based training that will aid in the upstream preparation of future critical care doctors.

Better Together will investigate the processes and outcomes of a group-based, peer-led mental health self-stigma program across multiple mental health settings. The objectives of the trial are as follows: Primary objective 1) Guided by the Consolidated Framework for Implementation Research (CFIR), identify the characteristics of the intervention, outer and inner settings, individuals and processes that influence the implementation of peer work roles using qualitative methods. Secondary objectives 2) Using qualitative methods and checklists of adherence, establish the feasibility, acceptability, fidelity and sustainability of peer worker roles in three diverse mental health settings. 3) Examine the service level outcomes of the implementation of peer workers: safety, person-centeredness and effectiveness, using qualitative methods. 4) Evaluate the effect of the peer-delivered Honest, Open, Proud Program on individuals’ self-stigma, empowerment, recovery, quality of life and satisfaction with services using both qualitative and quantitative methods. Whilst the trial is primarily exploratory, , we hypothesise that the Honest, Open, Proud Program will reduce participants' perceptions of self-stigma, and improve their perceptions of their own empowerment, recovery, quality of life and satisfaction with services. "Honest, Open, Proud" is a peer-led self-stigma reduction program, developed by renowned mental health consumer and principal investigator on the National Consortium for Stigma and Empowerment, Professor Patrick Corrigan. The program focuses on identity and disclosure as a means for reducing internalised stigma and promoting empowerment. "Honest, Open, Proud" peer facilitators guide participants through a workbook and activities that explore whether they identify as someone with a mental illness (or other similar terms), the pros and cons of disclosure and how to construct their story in a way that is safe for everyone if they do choose to disclose, particularly if they choose to be completely open such as through public speaking. The program will be delivered face-to-face, in a small group of approximately 8 participants. The delivery format is delivered in 3 x weekly 2-hour sessions, plus a 2-hour ‘booster’ session approximately 3-4 weeks later. Total participation time, including program sessions, outcome measures and the feedback session is approximately 10-12 hours across 8 weeks.

The is a pilot trial to test this initial prototype of the Shift app. We intend for 30 Junior Medical Officers (JMOs) to use the app for a period of 30 days. Using baseline and follow-up questionnaires and app usage data, the app’s usability, feasibility, and acceptability will be examined. The results from this pilot study will enable us to modify and optimise the app as necessary prior to testing its effectiveness in reducing depression in a large-scale randomised control trial.