ANZCTR search results

The purpose of this trial is to investigate the effects of nocturnal IHL-42X on apnoea hypopnea index, sleep quality and mood in healthy adults. This will be a 6- week, double-blind, placebo controlled randomised trial in patients with suspected or diagnosed mild to moderate Obstructive Sleep Apnoea (OSA) with 3 visits in total (V0, V1 and V2). It is hypothesised that the active treatment will reduce AHI, improve mood and improve well-being after 6 weeks supplementation compared to placebo.

This study is a two-part longitudinal, observational study. Part 1 of the study will be a cross-sectional analysis ofroutinely collected data from the Prince of Wales hospital falls, balance and bone health clinic (1st of February 2019 - 31st of July, 2021) to proivde a descriptive analysis of attendees. Part 2 of the study will involve a follow-up questionnaire completed via telephone by patients that consent to be involved in this element of the study six to nine months after their clinic appointment date to gain isight into the uptake of clinic recommendations. It is hypothesised that patients that have a positive attitude and intention towards falls prevention recommended by health professionals will be more likely to participate in such recommendations. Also patients that participate in multi-component recommendations (e.g. Stepping On falls prevention program) will have greater improvements in outcomes (e.g. number of falls, fear of falling) compared to patients in single component recommendations (e.g. medication review).

Title Autologous Protein Solution (APS) – the Biological symptom management of HIP osteoarthritis. The hypothesis of this study is that a single injection of APS (nSTRIDE, Zimmer Biomet USA) a product derived from the participant's own blood, is safe and leads to a reduction in hip pain and an improvement in hip function at 3 months which is sustained at 12 months. This will be tested in 10 participants aged over 40 years with painful hip osteoarthritis and mild to moderately severe structural change on x-rays.

A dietary intervention trial will be conducted in cognitively healthy subjects in sequential design. The trial will involve the consumption of increasing doses of a medium-chain triglyceride oil. Each dose will be consumed for 1 week and at the end of each dose period participants will donate blood samples, complete questionnaires and neuropsychological tests and have their anthropometric measurements and blood pressure taken. In addition, participants will complete a 3-day food records every week.

It is hypothesised that removal of dietary emulsifiers, which can help mix oil and water together, will treat gut inflammation seen in Crohn's disease. This proposal aims to address the main research question: Are dietary emulsifiers associated with breakdown of the intestinal barrier and inflammation? We have designed a low and high emulsifier diet and we plan to conduct a human dietary trial to examine the effects of a low emulsifier diet in patients with Crohn's disease. Crohn's disease patients will receive either a low emulsifier or controlled diet for 4 weeks. At the end of diet period, subjects will give blood, urine and faecal samples, which will be analysed for markers of inflammation.

This is a study to determine if vaginal laxity (looseness of the vagina) can be successfully treated using vaginal laser therapy. Currently there is no known effective treatment for this condition. For participants enrolled in the study, they will be assigned with equal likliehood to an active treatment with vaginal laser or sham (fake treatment) arm. Participants will receive 3 treatments, 4 weeks apart. We want to know how many women still have vaginal laxity 3,6 and 12 months after their final treatment.

Hypothesis: The use of prehabilitation and rehabilitation coordination and support using the Internet of things (via a smart phone App) will allow personalisation of therapy and improve recovery from knee replacement in these patients. This study will provide important information in these areas 1. Can the delivery of significant components of care be by the Internet of things (IoT). The PRIMO protocol would standardise components of care at RNSH. In NSLHD, up to 60% of patients are “out of area” This study will not include these patients but it is envisaged that the RECOVERY APP will be associated with improved outcomes in this group and they will be studied as part of a separate HREC application at an appropriate time. 2. Does the RECOVERY Platform result in improved adherence to rehabilitation prescriptions and improved outcomes in a range of domains that inform a new standard of care. This study is not sufficiently powered to show statistically significant changes nor does it have a comparative arm.

The Insights in Body Esteem survey is an exploratory project, seeking to investigate the experience of Australians, 18 years and over, in relation to their body esteem, and the impact these feelings have on their day to day lives. The project will contribute to an understanding of body image in Australia, and also guide the development of effective engagement practices in the prevention of eating disorders.

This study will evaluate the effectiveness and acceptability of the Virtual Reality (VR) workshop Enabling EDIE as a teaching resource for Allied Health Professionals (AHPs), Allied Health Assistants (AHAs) and physiotherapy students working with people with dementia. A short series of surveys will be used to assess the knowledge, perception, and impact on clinical practice of AHPs, AHAs and physiotherapy students that provide care for people with dementia. It is hypothesised that specific dementia-related virtual reality training will improve understanding, perception and clinical practice in dementia care. it is also anticipated that less experienced clinicians and students will benefit most from this type of training and are more likely to implement changes in routine practice following the Enabling EDIE workshop.

This study aims to compare high intensity exercise to standard pre-operative preparation on cardiovascular fitness and incidence of post-operative complications in major upper gastrointestinal cancer patients. Who is it for? You may be eligible to join this study if you are aged 18 years or above and are scheduled to undergo major upper gastrointestinal cancer surgery at John Hunter Hospital. Study details Participants in this study will be randomly allocated (by chance) to one of two groups. Participants in one group will receive standard pre-operative care, which consists of advice to improve fitness but no supervised or structured program. Participants in the other group will undertake prescribed, structured and supervised high intensity interval exercise over three sessions per week whilst on the wait list for major cancer surgery (approximately 30 days). This exercise will be primarily on a stationary bicycle and can bo done at home or in a hospital gym. All participants will undergo cardiovascular exercise testing upon enrolment and the week prior to surgery in order to assess any changes in fitness. A blood test will also be taken at the start and completion of the program, and a CT Scan used at the point of diagnosis and then 3 months following completion of the study. Participants will be followed for 90 days post-operatively in order to review any surgical complications, length of time in hospital, and other clinical outcomes. If the pre-operative fitness intervention is successful in this cancer population, and improved fitness relates to better outcomes, then borderline operative candidates may be able to undergo a similar program with a view to extending the option of curative surgery to a larger patient population.