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Overactive bladder is a term describing the clinical problem of urinary urgency +/-urgency incontinence. It is a bothersome condition that occurs equally in men and women. OAB places a burden on both the individual and the healthcare system. It is associated with reduced quality of life, increased risk of falls, high healthcare utilisation, personal cost and lower work productivity. This research study is the second part of a two-part study that aims to establish whether intervention with Near Infrared Red Light therapy delivered via a nasal prong can help to reduce the symptoms of overactive bladder. It is hoped that this research will lead to a more effective and standardised treatment plan for people with overactive bladder. The research intervention (Near Infrared Light) has successfully been used for other conditions where people are in pain.

The purpose of this study is to assess the safety and efficacy of an endoscopic procedure called “POEM” (Per Oral Endoscopic Myotomy). The POEM procedure is a novel endoscopic treatment used for motility disorders of the oesophagus. POEM is a minimally-invasive endoscopic therapy with similar clinical responses to current surgical treatments, and shown to have shorter recovery time and less post-operative pain. Who is it for? You may be eligible for this study if you are 18 years or older and have been diagnosed with the oesophageal motility disorder “Achalasia”. Study Details All participants will undergo the POEM procedure; performed with deep sedation administered by an anaesthetist (you are not likely to feel the entire process). The procedure itself involves an endoscope entering through your mouth into the oesophagus, and then a special tiny knife in the endoscope is used to cut away specific muscle fibers in the oesophagus. When this is done the endoscope will come back up through the mouth. You will be asked to return to the Gastroenterology clinic at 3 months, 6 months, 12 months, and 24 months following your procedure for follow-up visits. Because POEM has not been formally assessed in South Australia, we are interested to see how well this procedure compares to the current established treatments. We hope this research will help provide information on the safety and usefulness of POEM as a potential replacement for current treatments options for achalasia and other motility disorders of the oesophagus.

The FeBRILe3 project aims to look at the safety of earlier discharge home for well-looking, low-risk infants admitted to hospital with fever. It will monitor for unplanned hospital presentations or readmissions and other complications to show the safety and impact of this intervention in the WA population. We will collect information about all infants under 3 months old admitted to hospital with fever to provide further information about their signs and symptoms, investigation results, and diagnoses. We will also ask additional information from care-givers to understand their experience of during and after their hospital stay. We expect this information will help guide further management strategies to improve patient care and the hospital experience.

Mental health is in global jeopardy and devising efficacious promotive, preventative and curative solutions is paramount. In a progressively digital culture, program designers are replacing face-to-face (F2F) intervention delivery in favour of increasingly sophisticated online and mobile options. The paradigm shift overcomes numerous obstacles of inaccessibility, yet, online delivery poses unique challenges regarding the interrelated factors of adherence and human support. While human interaction is an intrinsic element of F2F interventions, program designers must evaluate how to add the human support component (e.g. dosage, type) back in to online programs to optimise adherence and outcome measures. This study will explore what influence graded levels of human support have on the outcomes of and adherence to an online, lifestyle-based mental health intervention. Participants will be randomly assigned to three Arms, differentiated by variant levels of human support: Arm 1 – standard online program with no additional human support; Arm 2 – same standard program as Arm 1 with additional personalised SMS support; Arm 3 - same standard program as Arm 1 with additional weekly online group discussion (i.e. videoconference). Measures of mental health and wellbeing will be collected for all participants at pre- and post-intervention and comparisons made between the Arms. Adherence to the intervention will also be compared between the Arms. This study will contribute to an evidence-based rationale for intervention planning, to maximise program efficacy through optimal human support and adherence. The study will also inform the optimal levels of human support when administering online interventions.

Children with bronchiectasis regularly experience exacerbations of their condition resulting in frequent hospitalisations and decreased of quality of life (QoL). Therapeutic exercise may reduce the incidence of acute exacerbations, which is a key predictor of future lung function decline and morbidity. This study aims to determine if a tailored, 8-week therapeutic exercise program delivered to children aged 6 to 12 years with bronchiectasis prevents acute respiratory exacerbations. The primary hypothesis is that children who undergo the exercise program will have fewer exacerbations over a 12-month period than children who do not receive the intervention.

Traditionally during maternity emergencies, it is recommended that a single leader take charge. However, in many critical circumstances there may be too many things for a single leader to do. This project aims to test a system where the leadership tasks can be shared between two leaders to determine if this is superior to a singular leadership model.

The study aimed to assess the impact of nudge strategies embedded within an invitation to attend a healthy menu planning workshop, on childcare service workshop registration. We hypothesised that the use of these strategies would result in an increased number of registrations from childcare services that receive the intervention, compared to control. Acceptability of the invitations and contextual barriers to workshop attendance were assessed at follow-up. Intentions to implement dietary guidelines for the sector and service characteristics were also obtained.

Inflammation is central to the development and progression of atherosclerosis. Neutrophils are the most abundant immune cell in circulation and contribute to atherosclerosis-associated inflammation. Colchicine is an anti-inflammatory agent currently approved for the treatment of gout, familial Mediterranean fever and acute/recurrent pericarditis. There is mounting evidence that indicates colchicine is effective at reducing ACS recurrence rates by inhibiting specific inflammatory pathways. An anti-inflammatory effect of colchicine on neutrophils has been noted in patients with vasculitis, although this has not been examined in those with coronary artery disease. Colchicine use has been proven to be safe, well tolerated and is inexpensive and readily available. The aim of this study is to assess the acute effect of colchicine (1.5 mg orally) on neutrophil function in patients with coronary artery disease. We hypothesis that colchicine will inhibit neutrophil hyper-reactivity seen in these patients.

Elective and non-elective caesarean section (CS) rates have been increasing in Australia over the past 20 years. Increasing antenatal morbidity, has meant that surgical site infection (SSI) post CS is an important issue effecting Australian women. Populations most impacted include low socioeconomic and regional communities where high rates of antenatal comorbidity augment the incidence of SSI. Despite a recent trend towards supporting the development of evidence based bundled approaches to SSI reduction, there remains paucity in data proving efficacy and supporting bundle implementation. This study aimed to develop, implement and assess an evidence based caesarean infection prevention “CIP” bundled intervention to reduce SSI rates following CS in a high risk rural population. The study is a pre-post intervention study with 3 phases and included all women undergoing CS at a regional referral hospital between December 1st 2016 and December 31st 2018. A 12 month retrospective pre-intervention review identified all women who developed a post CS SSI. A comprehensive literature review informed the development of the intervention, which was implementation in December 2017. Prospective data collection for a subsequent 12 month period was collected on all women who underwent CS with pre and post comparative data analysis.

Rehabilitation is an important factor that improves recovery from total knee arthroplasty (knee replacement surgery). However, no clinical guidelines currently exist to inform recovery pathways following surgery, likely due to the lack of evidence to suggest who may benefit from rehabilitation, when and where this service should be delivered, and what services should be provided. This has led to an inconsistent approach to rehabilitation. The aim of this study is to develop a recovery pathways stratification tool based on a comprehensive evaluation of individual patient data, including physical performance assessments and physical, social, and mental health evaluations. Ultimately this tool will allow a personalised approach to refer patients to rehabilitation pathways based on their own needs and circumstances.