ANZCTR search results

The aim of this study is to see if the detrimental cognitive effects of 36 hours of sleep deprivation can be offset by applying slow wave oscillations induced by non-invasive brain stimulation to mimic the effects of slow wave sleep. The study will target healthy adults. Effects will be compared to sham stimulation and a brief nap. It is hypothesised that slow wave brain stimulation will protect the brain from the detrimental effects of sleep deprivation, and will provide similar benefits to that provided by a brief nap.

This study will enrol participants 6 months of age through age 13 with molluscum contagiosum (MC) across up to 6 sites in Australia. Participants will be randomly placed into one of two groups in a 2:1 ratio. This means twice as many children will receive the study treatment (Zabalafin Hydrogel) compared with those who receive the placebo. The purpose of the study is to see how well Zabalafin Hydrogel 9.5% works and how safe it is when used twice a day to treat MC. The main goal is to find out how many participants have more than 75% of their MC cleared by Week 16.

There is evidence that the deepest form of sleep, slow wave sleep, may be a critical target for maintaining cognitive function and reducing the risk of developing Alzheimer’s disease. One way deep sleep may affect the risk of Alzheimer’s disease risk is by helping the brain and body clear out chemicals. We aim to test whether improving deep sleep using an at home EEG device helps with this clearance, and explore what health and lifestyles factors might influence the results, including brain toxin and volume level as measured using MR-PET scans..

People with highly variable sleep apnoea from night to night have different underlying breathing and airway characteristics compared to people whose sleep apnoea is more stable. Detailed in-lab measurements across several nights can explain why sleep apnoea severity changes so much for some people but not others.

Recently, a monitor called the Newborn Infant Parasympathetic Evaluation (NIPE) has been used to study pain in children under 2 years of age, as it assigns a numeric value to the pain response. It does this by analysing the variability of the heart rate, and studies have shown that it accurately tells us when the child is reacting to pain during surgery. Newborn babies undergo a range of painful procedures while hospitalised, including major surgery and minor procedures. These procedures can be distressing to the child and the child's carers, and thus it is important to ensure that we accurately recognising and treating the pain these can cause. Additionally, some newborns experience a severe condition caused necrotising enterocolitis (NEC), which can be treated by stopping feeds and administering antibiotics. However, in some cases this needs to be escalated to surgery. Our study aims to better understand the pain experienced by children who undergo major surgeries and minor procedures, and to observe what causes and helps their pain. Additionally, our study aims to investigate whether babies with NEC who experience more pain are more likely to progress to requiring surgery to treat their condition.

To compare the outcome of daily intermittent intravenous dosing of ceftriaxone verses continuous intravenous infusion of cefazolin by looking at treatment duration in patients admitted with cellulitis to the CHQ at Home’s Hospital in the Home program from 1st of January 2020 to 30th of June 2024.

This study will evaluate an evidence-based online relationship program in an Australian context with individuals experiencing difficulties with alcohol or substance use, and dissatisfaction in their relationship with their intimate partner. The project will address major limitations in the AOD sector by taking a relationship science approach to address relationship dysfunction and breakdown in those couples where at least one partner is affected by substance misuse. Given that the OurRelationship program has already been shown to be highly effective in the wider community, the aim of this proposed project is translational in nature; specifically targeting individuals in the community who have unmet needs regarding problems in their relationships in the context of problematic substance use. It is expected that the application of the OurRelationship program to this section of the community will enhance their relationship functioning, confidence, stability, and quality, and reduce partner conflict and dysfunction.

This study is assessing the pharmacokinetics, safety and tolerability of single doses of eRapa compared to Rapamune in healthy volunteers. Who is it for? You may be eligible to join this study if you are aged between 18 and 65 years old who are overtly healthy as determined by screening study assessments. People who have been diagnosed with cancer will not be eligible for this study. Study details This healthy volunteer study is designed to compare the absorption of a new formulation of rapamycin called eRapa and a currently available formulation known as Rapamune for the treatment of familial adenomatous polyposis. Familial adenomatous polyposis (FAP) is a rare inherited disease that increases the risk of developing bowel cancer at an earlier age than the general population. Participants in this study are randomly allocated by simple randomisation to eRapa or Rapamune (rapamycin) as a first dose and then vice versa for the second dose 14-20 days after the first dose. Pharmacokinetics, safety and tolerability and will be assessed at regular intervals using clinical examinations and blood tests. The rate and predictability of the absorption of eRapa will be compared to Rapamune. It is hoped this research will contribute to improving clinical outcomes in patients with familial adenomatous polyposis (FAP) by preventing or delaying disease progression.

Despite how common and impactful child sleep problems are, they are not routinely treated within public hospital outpatient services, and there is a shortage of professionals trained in paediatric sleep. Our team has developed the Lights Out program, a caregiver-directed intervention that teaches practical strategies to manage child sleep problems. Research has shown that Lights Out improves children’s sleep, anxiety, and behaviour, as well as caregiver wellbeing, and can be delivered face-to-face or via videoconference. This study responds to an urgent request from Queensland’s two largest public hospital paediatric outpatient services to adapt the Lights Out program for routine care. Caregivers of children aged 3-to-12 years with sleep problems will be recruited from two paediatric outpatient clinics. Families will be randomly assigned to receive either the Lights Out program or usual care. Child sleep and wellbeing, as well as caregiver wellbeing, will be assessed over six months. The study will also examine how acceptable the program is for families and clinicians to support wider delivery in public health settings.

About 15% of the workforce in Australia do shift work, which can lead to sleep disturbance and circadian misalignment. This negatively impacts health and wellbeing and could impact organisational outcomes. In this study we plan to examine whether a digital sleep health intervention can improve sleep, mental health and organisational outcomes in healthcare workers. We also want to understand the feasibility and scalability of this tool and any enablers and barriers to workplace adoption of the app. Results from this study will help us understand the feasibility of the app to improve healthcare workers' sleep, improve organisational outcomes, and if it is feasible for workplace-level adoption.