ANZCTR search results

Absolute uterus factor infertility (AUFI) affects 1-5% of reproductive-aged infertile women AUFI may result from: - Major congenital anomaly e.g. MRKH syndrome where the woman is born without a uterus; - Hysterectomy for benign or malignant reasons; - Acquired condition rendering the uterus non-functional e.g. Asherman syndrome (intra-uterine adhesions). Traditionally, women with AUFI could only obtain parenthood through gestational surrogacy or adoption. However, these options may not be acceptable for some women and their partners due to legal, religious, financial or ethical concerns. Furthermore, achieving a pregnancy and delivering a baby is a basic human right. Recently, Uterus Transplantation (UT) has become an alternative option for women of reproductive age with AUFI to bear children. As of January 2019, UT has been successfully performed, with 13 reported live births worldwide – 8 in Sweden, 2 in the United States, and 1 in Brazil, China, and India . Of the 13 live births, all have been from a living donor UT, except the 1 in Brazil which used the uterus from a deceased donor Once the results of the initial trial demonstrate efficacy, safety and operational viability, we intend on providing a nation-wide tertiary referral service offering UT as a viable option for women with AUFI through RPAH. In order to achieve this, we need to create a multi-disciplinary team with adequate infrastructure for the selection, assessment, and management of appropriate patients as donors and recipients.

To examine the efficacy and cost-effectiveness of a modified traditional Chinese medicine formula (GynoclearTM) as a treatment for endometriosis related pain and fatigue. The project will utilise a placebo controlled, double blind, randomised controlled trial involving reproductive aged women surgically diagnosed with endometriosis. Baseline scores for pelvic pain, fatigue, painful intercourse (dysparunia) and rescue medication will be collected over four weeks. Women will be randomly allocated in a 1:1 ratio to active (GynoclearTM) or placebo capsules. Six capules will be taken daily for three months. The primary outcome is change in daily pelvic pain score at the end of the intervention. Safety and adverse event data will be collected during the trial and at a one month follow up period. If GynoclearTM shows evidence of efficacy and safety it will be another possible treatment option for the over 360,000 Australian women with endometriosis.

The purpose of this study is to determine the costs associated with post-operative complications of those undergoing a rectal resection. Accurately defining the costs of complications allows institutions to make more informed decisions as to what areas comprise a significant cost percentage, and then implement strategies to mitigate this. Who is it for? This is a retrospective study evaluating the costs of complications of adult patients who underwent a rectal resection at the Austin Hospital between January 2013 and June 2018. Study details The aim of this study is to outline the health costs of postoperative complications in patients who undergo rectal resection surgery. We consider the incidence, type and severity of these complications and expand on the surgical method used in relation to rectal resection. Further, we highlight the importance of evaluating the components of healthcare cost profiles relevant to patients undergoing rectal resection. We hypothesise that patients who suffer complications would incur greater costs as compared to patients who did not have a complication. We also hypothesised that as the complication severity increased, there would also be an increase in costs. It is hoped that this study will outline the costs of postoperative complications in patients who undergo rectal resection surgery, and highlight the importance of evaluating the components of healthcare cost profiles relevant to patients undergoing rectal resection.

Lung cancer is the leading cause of cancer-related mortality and morbidity in Australia, with more than 8000 Australians predicted to die in 2018 alone. Due to the poor outcomes experiences by many lung cancer patients, clinicians attempt to provide rapid review, diagnosis and treatment and adhere to the timeframes suggested in the Cancer Council’s Optimal Care Pathway. Whilst scientific end points, such as survival are important, patient reported outcomes, such as quality of life and satisfaction with care are also vital. This move towards more patient-centric care is being championed in Western Australia by the Continuous Improvement in Care – Cancer (CIC-Cancer) Project. Are you eligible to take part in this study? This study aims to establish if providing guideline-driven care, in terms of timeliness, improves patient satisfaction amongst people with lung cancer. You may be eligible to take part if you have primary lung cancer and are undergoing treatment and have consented to have your clinical information collected by the CIC-Cancer database. What does the study involve? Patients will be asked to complete an 18 question survey at the time that they start treatment for lung cancer. The survey will assess different areas of patient satisfaction with care, including access to appointments and communication with their doctor. Patients will not be obliged to any other follow up. How will involvement in this study help patients with lung cancer? This study will help us to validate the Cancer Council Optimal Care Pathway and ensure that striving to achieve rapid review and treatment really is making patients more satisfied with their care.

The purpose of this study was to determine the costs associated with post-operative complications of those undergoing a colonic resection. Who is it for? Eligible patients included adult patients who underwent a colonic resection at the Austin Hospital between January 2013 and June 2018. All data was retrospectively collected. Study details Data was collected on any complication experienced by patients who underwent a colonic resection at the Austin Hospital between January 2013 and June 2018. It is hoped that this study will: 1) Quantify the costs implicated by postoperative complications following colonic resections including pharmacological costs, medical costs, operative costs, intensive care unit costs and ward costs. 2) Quantify the impact of postoperative complications on costs within the following patient cohorts: a. Emergency and elective procedures b. Laparoscopic, open and combined procedures c. Malignant and non-malignant diagnoses 3) Identify key patient and perioperative variables associated with increased costs and adverse patient outcomes to ascertain areas for improvement allowing the development of evidence-based guidelines with the ultimate goal of improving patient outcomes and efficiency of our health services.

In this study we aim to see if biofilms (groups of bacteria) are present in HS lesions, and see what bacteria are present, how they are grouped and what effect they have on the skin and how this relates to disease severity.

Working memory (WM) training using emotional stimuli has been designed to improve the mental control of emotional information. The aim of this project is to test whether individuals with elevated social anxiety would benefit from WM training with emotional stimuli. The project aims to build on a previous project (ACTRN12618001196235) and further explore the effects of WM training with emotional stimuli. It is anticipated that individuals with elevated social anxiety who engage in a WM training task with emotional stimuli, relative to those who engage in a control training task, will exhibit the following after training: (a) reduced social-evaluative self-beliefs, (b) increased self-esteem, (c) improved cognitive flexibility, (d) improved adaptive thought generation, and (e) decreased anxiety.

The human microbiome, the population of microbes occupying various body sites, is already known to have a major impact on human health with the changes in the gut microbiota during pregnancy known to be particularly fascinating. However, there is limited research on the microbiome and its relationship to maternal and newborn health and disease. Therefore, the aim of this study is to recruit a large perinatal and newborn cohort, of approximately 2000 participants, in order to comprehensively investigate the microbiome during this critical period of a mother and child’s life. Women will be recruited prior to conceiving a child, to fully examine the microbiota, and observe the changes from pre-conception, conception, and pregnancy through to birth and into the first year of thechild's life. There is a projected time commitment for participants of 22-33months, depending on time of conception.

The purpose of this study is to assess the utilisation of an Implantable Loop Recorder to aid in the management of symptom control of Paroxysmal Atrial Fibrillation.We hypothesise that an Implantable Loop Recorder can be effectively used in a nurse led cardiologist supported AF clinic to guide and co-ordinate the management of patients with a high burden of symptoms related to their Atrial Fibrillation.

Peripheral IV cannulation is one of the most frequently performed invasive procedures in the hospital setting, and an essential means of providing hydration, nutrition and medication to admitted patients, including neonates . The insertion, monitoring and maintenance of these devices, to prevent complications, are an important component of neonatal nursing care. The most common complications of PIVC use include extravasation, infiltration, occlusion, infection, and phlebitis - accounting for the failure and removal of 95% of PIVCs. Although these complications are usually minor, some neonates may experience serious, or even life-threatening sequelae, with the potential for long-term functional difficulties, significant scarring, and psychological effects. The current failure rate of PIVC in the neonatal population is estimated at around 60%, however the optimal securement method of a PIVC has not been well established. We have designed a randomised controlled trial to assess whether using a specifically designed splint and protection device may be useful to prevent PIVC failure as compared to standard splinting and securement in the neonatal population. Our hypothesis is that the specifically designed splint and protection device will significantly decrease PIVC failure as compared to standard splinting and securement in the neonatal population.