ANZCTR search results

This study will aim to test whether a self-directed behavioural activation intervention is more effective in reducing depression symptoms and increasing subjective wellbeing and value-consistent behaviours in a non-clinical adult sample if enhanced with self-compassion training (EBA condition) than if delivered as a stand-alone intervention (BA condition). Several hypotheses will be tested, including: (a) The mean rate of change in (i) depression symptoms, (ii) positive affect, (iii) negative affect, (iv) satisfaction with life, and (v) value-consistent behaviour will be greater amongst participants in the behavioural activation condition than the waitlist control condition. (b) The mean rate of change in (i) depression symptoms, (ii) positive affect, (iii) negative affect, (iv) satisfaction with life, (v) value-consistent behaviour, and (vi) self-compassion will be greater for participants in the EBA condition than the BA condition. (c) For participants in both the BA and EBA conditions, individuals with greater pre-test depression symptoms will have a larger rate of change in (i) positive affect, (ii) negative affect, and (iii) satisfaction with life than participants in the waitlist control condition. (d) Participants in the EBA condition will be more likely than those in the BA condition to complete online survey measures (which will used as a proxy measure for treatment continuation).

The aim is determine whether connectivity of the right parietal cortex predicts response to an inhibitory brain stimulation paradigm (TBS), to induce spatial neglect in healthy adults. We hypothesis that the connectivity of the stimulated parietal cortex prior to an inhibitory brain stimulation paradigm, will predict the degree of induced left-sided neglect as measured by behavioural responses.

This randomised controlled trial will assess the efficacy of topical dorzolamide achieving macular hole closure prior to vitreoretinal surgery.

Diabetic retinopathy, (or diabetic eye disease), is the leading cause of preventable vision loss in working adults. With early diagnosis and treatment, sight threatening diabetic retinopathy can be prevented. To ensure early detection and timely treatment, it is recommended that a person with diabetes has an eye examination at the time of diabetes diagnosis, then at least every two years thereafter. Research has shown that only around one in three Australians actually follow these recommendations and research into the compliance of regular screening methods (such as referral to an optometrist or to private or public eye clinics) has shown that only half of Australians attend these appointments. However, when screening is held within a general practice, better compliance and attendance is achieved. The selected general practices are now offering diabetic retinopathy screening. This study aims to find out if the community find this is an acceptable way to screen for diabetic retinopathy and to find out the rate of previously undiagnosed diabetic retinopathy.

Atrial fibrillation (AF) remains a frequent complication after coronary artery bypass graft surgery (CABG) with a rate of occurrence from 10 to 40%.. This study will assess the ability of a novel treatment (NP202) to prevent post operative atrial fibrillation in comparison to a placebo. NP202 is a small molecule that inhibits a protein that is central to atrial fibrillation. Subjects will be treated with NP202 or placebo for 3 days prior to their surgery and through the duration of their hospital stay. After surgery, the amount of atrial fibrillation will be assessed during the in hospital recovery period.

Our overall objective is to demonstrate whether LCI increases the detection rate compared with high-definition white light (current standard of care). The purpose of this study is to compare the rates of polyp detection with Linked Colour Imaging (LCI) and high-definition white light in patients undergoing elective colonoscopy. Who is it for? You may be eligible for this study if you are aged over 18 and are undergoing elective colonoscopy at the Gold Coast University Hospital. Study details All participants in this study will undergo a single colonoscopy as planned. The type of light used will be randomised by chance. We will record where polyps were found and their size. Any cancerous or pre-cancerous appearing lesions detected will be treated as per standard procedure. Resected polyps will be pathology tested as part of your routine care. No tissue samples will be obtained or stored purely for research purposes alone. The results of your tissue analysis will be de-identified and used only to confirm that lesions seen during your colonoscopy were really polyps. It is hoped this research will demonstrate whether LCI increases the detection rate compared with the current standard of high-definition white light.

This study aims to produce an Aboriginal Health Practitioner coordinated risk factor management program to reduce cognitive decline and functional impairment in Aboriginal Australians aged 45 years and over. The Dementia prevention and risk management program for Aboriginal Australians (DAMPAA) program will include AHP coordination and care planning of a) an exercise program including falls prevention strategies; b) cardiovascular risk management. This will be achieved through a 5 year research project in partnership with three ACCHS’s by: 1) Refining and piloting an intervention program (DAMPAA) that targets key dementia risk factors for Aboriginal people, and is based on existing best practice guidelines and cultural and service provider recommendations. 2) Completing a randomized controlled trial (RCT) comparing the DAMPAA program with usual care; 3) Evaluating the efficacy and cost-effectiveness of the DAMPAA. Significance: Given the rapid ageing of the Aboriginal population, the impact that dementia has on Aboriginal communities, and the resulting financial cost to society, there is a pressing need to develop and translate programs capable of reducing dementia in Aboriginal Australians. This project will produce a prevention program designed to meet the needs of Aboriginal Australians at risk of dementia.

Contemporary thinking suggest that pain may be enhanced by the messages that health practitioners convey to patients in their initial meeting as they have been shown to have a strong influence upon their prior beliefs . Despite there being a very weak relationship between observable tissue pathology and symptoms research suggests that clinicians commonly use tissue based structural descriptions to explain clinical status in people with persistent musculoskeletal pain problems . The aim of this study therefore is to examine the instantaneous effect of diagnostic messaging on pain and function in people with AT. To achieve this, we will assess pain and leg stiffness with hopping in people with AT before and after a standard diagnostic discussion that includes discussion of tendon pathology and compare these results with participants who receive a diagnostic explanation that does not reference tendon pathology.

In patients with hip fracture, low haemoglobin (Hb) levels are associated with post-operative complications, mortality, and increased hospital Length of Stay (LOS). A pre-operative Hb is taken on admission to the Emergency Department at Sir Charles Gairdner Hospital (SCGH). At the time of surgery, admission Hb levels may not be reliable indicators of current patient Hb status due to continual acute fracture-related blood loss, haemo-concentration and delays to surgery. This cohort study will investigate if an intervention of an Hb test immediately before surgery will improve patient outcomes. We will compare outcomes between 300 prospective patients and 300 retrospective patients. The outcome measures include hospital LOS, use of blood transfusions, Post-Anaesthetic Care Unit LOS, post-operative complications, admission to critical care areas, and survival to discharge. We foresee the results of this study may improve patient outcomes.

There continues to be a culturally embedded perspective that performing artists may need to “suffer for their art” and often wellness and artistry are treated as if they are unrelated. This randomised controlled trial will compare the effect of a 7week wellbeing and performance enhancement program with mindfulness, to a waitlist control group who receive the education only (without the mindfulness component), for Professional Ballet Dancers employed at The Australian Ballet. Dancers will be asked to complete electronic questionnaires and semistructured interviews in addition to completing the wellbeing program.