ANZCTR search results

To determine the association between patient serum vitamin d status and clinical IVF outcomes such as clinical pregnancy and live births arising from fresh embryos transferred. Our hypothesis is that those with a sufficient vitamin d status (> 50 nmol/L) will have more favourable outcomes in comparison to those with insufficient levels (< 50 nmol/L). We will examine vitamin d status as a continuous and as categorical variables while adjusting for various other infertility parameters including patient age and ovarian reserve.

The aim of this study is to define what is a normal blood glucose level post meal in people without diabetes. This study involves consuming five standardised test meals of varying macronutrient composition over five days. To assess the effect of each meal on post-meal blood glucose participant glucose levels will be measured continuously for 4 hours post- meal.

This study aims to assess changes in body composition following TIPS procedures in decompensated cirrhosis. Patients already referred for TIPS will be recruited from inpatient and outpatient clinics to participate in an observational study with 6 months of follow up. This aims to comprehensively analyse the changes body composition including lean muscle mass, adipose tissue, muscle strength and performance measures and correlate these with biomarkers of immune function, portal hypertension and muscle regulation.

Aortic stenosis (AS) is the most common heart valve disease in the Western World. Transcatheter aortic valve implantation (TAVI) has substantially expanded the therapeutic options available to patients suffering from severe AS. However, despite the rapidly expanding clinical use of TAVI, patients remain at high risk for both thrombotic/clotting (e.g., stroke and valve thrombosis) and bleeding complications. Optimal preventative therapy is essential to minimise thrombosis without incurring excessive bleeding risk. Current recommendations for clot prevention in TAVI are extrapolated from heart vessel stunting (also known as percutaneous coronary intervention or PCI) data despite significant patient and procedural differences that likely result in different risk profiles. Until this is addressed, clinicians are left to advise and treat their patients without essential information. This observational study will recruit 40 patients undergoing TAVI, PCI and AVR to compare the clotting / bleeding changes that occur during the procedure. Blood will be sampled from each patient at 5 time points depending on the procedure. These blood samples will be assessed for the bleeding / clotting potential of the blood at that time using the latest blood clotting tests including ROTEMSigma, TEG6s, MultiPlate and various other specialised laboratory tests.

The aim of this project is to evaluate the Safety of Immune Cells for Patients with Relapsed Leukaemia or Lymphoma after chemotherapy. Who is it for? You may be eligible to join this study if you have persistent or relapsed B-cell malignancy after standard chemotherapy. Study details Patient derived CAR19 T-cells will be administered intravenously after lymphodepleting cyclophosphamide and fludarabine. This T-cell therapy may be administered alone or in addition to salvage chemotherapy. Three CAR19 T-cell dose levels will be assessed within each patient: 1x10^7cells/m^2, 5x10^7cells/m^2 and 1x10^8/m^2. Dose escalation will be determined 4 weeks after the last dose dependent on persistence of disease, no severe toxicity and falling CAR19 T-cell numbers. Patients will be monitored for early and long term toxicity, persistence of CAR T-cells and disease response. If successful, this treatment will enable the widespread application of CAR19 T-cells to patients with few other effective treatment options.

Pain is one of the most detrimental non-motor symptoms of Parkinson’s disease (PD), with up to 85% of people with PD experiencing pain in some form. Despite this, pain is often undiagnosed and frequently overlooked by clinicians and other healthcare professionals, leading to a lack of treatment (Ford, 2010). This study seeks to test the efficacy of a non-invasive brain stimulation technique (tDCS) for the treatment of pain. This treatment has resulted in improvement of pain in people with Multiple Sclerosis and fibromyalgia. It is hypothesised that tDCS will reduce pain in PD.

Singing Cords is a peer-led therapeutic group singing program for people with spinal cord injury. Spinal cord injury of the neck region impairs the persons’ ability to breathe deeply, raise their voice and cough to clear their airways placing them at high risk of respiratory infections. Group singing has been found to enhance mood, social connectedness, breathing function and voice projection in people with neurological dysfunction. This three month program will build on existing evidence by piloting a multi-disciplinary peer led structured program led by a vocal coach and professional singer who has a spinal cord injury. The teams aims to determine if this form of rehabilitation is of benefit and can be incorporated into the existing model of rehabilitation.

To combat the global burden of obesity and its co-morbidities, a major challenge lies in the development of effective therapies that increase fullness and satiety, and result in improvements in blood glucose control, while lacking adverse effects that are often associated with current therapies. Meal ingestion brings about changes in GI functions that are associated with slowing of gastric emptying, gut hormone release, regulation of blood glucose and energy intake. Among all three macro-nutrients, lipid seems to be the most potent. The effects of fat on gastric emptying, APD motility, gut hormones, energy intake, and blood glucose rely on fat digestion products, namely fatty acids, are an essential requirement for intestinal fat sensing. Several studies have demonstrated effects of C12 on GI functions and energy intake. However, the effects of orally ingested C12 on the suppression of appetite over a period of time (for example, potential hunger-suppressant effects in the lead-up to meal ingestion), or its effects on gut hormones, gastric emptying of a meal and the relationship with postprandial blood glucose in both normal-weight and obese people remain unknown.

The aim of this research is to confirm the safety and test the effect of EU-C-001 on reducing raised pressure in the brain. Patients with traumatic brain injury (TBI) will receive the best standard of care for their condition, and will also receive one of three different treatment levels of EU-C-001 or a placebo. The hypothesis is that the patients receiving EU-C-001 will have a stronger reduction in the pressure in the brain than patients who receive the placebo treatment.

Maintaining blood glucose within a narrow range is a key target for individuals with Type 2 diabetes mellitus (T2DM). Despite the universal acknowledgement of exercise as an important component in the management plan for T2DM individuals, the importance of exercise timing relative to meals and time of day, has only recently been considered. Therefore, this project aims to establish whether post-meal exercise training in the morning or evening is more effective on glucose control in individuals with T2DM. We hypothesise that 12-weeks of exercise training will significantly improve glycaemic control and postprandial glucose responses, with the performance of evening exercise being associated with greater improvements when compared to morning exercise.