ANZCTR search results

This study will test whether it is feasible to collect information on quality of life in patients living with myeloma and provide this to treating clinicians in real-time at clinical visits. Who is it for? You may be eligible to join this study if you are aged 18 years or more and have newly diagnosed multiple myeloma for which you have not received any prior treatment or are within 7 days of day 1 of treatment. Study details Participants will be randomly allocated (by chance) to one of two groups. Participants in one group will complete a quality of life questionnaire before 4 clinical visits and a summary of results of concern are provided to the treating clinician before the first 3 visits. The clinician is made aware that results from the questionnaire summary are to be taken into account in the patient's care. Participants in the other group will complete the same questionnaire before visits 1 and 4 only, and results are not provided to the treating clinician. Feasibility of the intervention will be assessed by patient and clinician evaluation surveys, clinician interviews and site study coordinator observations. Quality of life scores will also be compared between groups. The theory is that increasing clinicians' awareness of issues affecting patients quality of life could help to improve patient care.

This research study is being conducted in order to gather information about the overall clinical performance and ease-of-use of the DELTA Disposable Delivery System, an instrument used in cataract surgery to implant the intraocular lens (IOL) into the eye. Delivery systems are commonly used in cataract surgery, this study is simply testing a new type of delivery system. Intraocular lenses are implanted as part of routine cataract surgery to restore vision.

Familial hypercholesterolaemia (FH) is the most common and serious cause of inherited high cholesterol and untreated leads to 50% of male and 20% of female patients suffering a fatal or non-fatal heart attack by age 50 years. Most individuals with FH are unaware they have the condition. The high prevalence of FH (1 in 250), high rates of undiagnosed children and fact that heart attacks in early adult life can now be prevented with appropriate management in childhood, means that new approaches to detection are required. Universal screening of children for FH at age 1-2 years, by measuring a total cholesterol level at the same time as a routine immunisation has been proposed. We hypothesise that screening children aged 1-2 years with a total cholesterol level, taken at the time of a routine immunisation will be feasible, cost effective and acceptable to parents.

This feasibility pilot study will evaluate whether a structured Healthy Brain Ageing (HBA) cognitive training (CT) and psychoeducation program delivered as an online intervention (i.e. CogNet) is efficacious for cognitive performance. The program is designed to improve cognitive and psychosocial functioning in older adults with Mild Cognitive Impairment (MCI). While the program has been shown to be successful in over 400 participant’s to-date, thus far we have only been able to offer our HBA intervention to those participants who were both able to physically access our specialised facility and staff, and were agreeable to participate in a group-based intervention. By translating this program to an online platform, we are able to make it more accessible for older adults ‘at risk’ for dementia and we now seek to evaluate the efficacy, feasibility and acceptability of the CogNet intervention in a group of older adults with MCI.

Our research has identified that many stroke survivors have poorly managed risk factors after stroke and many report ‘unmet needs’. To address these issues, we hypothesise that a cardiac rehabilitation program adapted for stroke survivors can improve secondary prevention of cardiovascular disease. Cardiac rehabilitation programs include exercise to increase cardiorespiratory fitness and educate people on ways to manage their health to prevent further cardiac events. These programs are known to reduce recurrent cardiac events in a cost-effective way. The specific aim is to run a pilot study of an adapted cardiac rehabilitation program in a group of stroke patients to examine its feasibility, acceptability and effect on cardiovascular risk factors and health-related quality of life. The program to be piloted takes into account the feedback from this broad range of stakeholders. The co-designed program will run for 7 weeks. It will include 1 hour of group exercise that can be adapted to suit different levels of function using a combination of standing and seated exercises with addition of light resistance, if appropriate. Following the exercise training, group-based discussion around a variety of topics will be led by a nurse facilitator with expert input into the content from physiotherapists, exercise physiologists, nutritionists and pharmacists. The exercise program will be designed and monitored by exercise physiologists and physiotherapists. The program will leverage off existing resources developed by the Stroke Foundation for stroke survivors and link into their existing online support systems to increase the maintenance of the program for participants. We will run 2 groups of 5 people per group in the first half of 2019. The study includes baseline assessment, program delivery for 2 hours per week for 7 weeks, a 1 week follow-up assessment and a 6 week follow-up assessment.

Patient engagement can result in the improvement of health outcomes, reduced healthcare costs and increased patient satisfaction. However, shortcomings in communication of care processes, treatment expectations and possible side effects from health professionals to patients persist. This project aims to test a behaviour change strategy involving the use of a specialised notepad to enhance the patient voice in early post-operative wound care. The notepad will be co-designed by patients, researchers, and hospital clinicians, It will provide patients with example questions, and will provide a place for patients to record their questions as they think of them, It will be provided to patients undergoing hip or knee replacement surgery at Frankston Hospital in Victoria, Australia.

This study is evaluating the long term and safety and tolerability of ZYN002, a clear gel that can be applied to the skin (called transdermal application) twice a day for treatment of symptoms of Fragile X Syndrome (FXS) Who is it for? Patients who have been diagnosed with Fragile X Syndrome and are aged between 3 and 18 years old who have participated in the ZYN2-CL-016 double-blind study and meet certain eligibility criteria. Study details Eligible participants will undergo up to a 52-week treatment period. Participants who are taking anti-epileptic drugs may undergo an additional 1-2 weeks of treatment to taper off study drug treatment. All participants will be assigned to ZYN002. Parents/ caregivers will be instructed on proper application of the gel. The gel will be applied to clean, dry, intact skin of the upper arms/ shoulders. Participants whose weight changes during the course of the study may have their doses changed at the investigator’s discretion on or after the Month 1 visit, or reduced due to tolerability issues at investigator’s discretion. Blood samples will be collected for safety analysis of ZYN002. Additionally, the parents/caregivers will be asked to complete some questionnaires. There will be other questionnaires and scales that will be completed at the site by the study doctor and/or with the participant and their parents/caregivers. Participation in this study may help the child’s/ adolescent’s FXS symptoms; however, we cannot guarantee that he/ she will get any benefits from this study. The results of this study may benefit future patients.

This study is the first to test a new physiotherapy approach to preparing for knee replacement surgery. This new approach is called PACT- Physiotherapy informed by Acceptance and Commitment Therapy. This is a method often used by psychologists to help people experiencing a range of issues that affect their mental health. This study is a pilot study, testing the new approach in 51 people and assessing results from a patient, therapist and hospital perspective before we use this approach in a larger study or in clinical practice.

This aim of this study is to establish the feasibility and preliminary efficacy for a brief parent mediated intervention for parents of children with autism aged between 2-6 years of age. The purpose of this research is to determine the effectiveness and acceptability of an integrated treatment approach that aims to improve maladaptive behaviours and core social communication symptoms in children with autism and parenting, parent-child interactions and parental well-being for their parents. It is hypothesised that this intervention will be acceptable to parents and effective in reducing child externalising behaviours, improving the quality of parent-child interactions and parenting practices.

We are conducting a research study to compare the effects of daily use of motion-control and neutral walking shoes on lateral tibiofemoral osteoarthritis clinical outcomes, over 6 months. To do this we will randomly allocate participants to receive either i) motion-control or; ii) neutral walking shoes. Participants will be provided a pair of shoes from their allocated group, to be worn daily for 6 months (minimum of 6 hours/day).