ANZCTR search results

Circadian misalignment disrupts REM sleep, a stage of sleep which is important for fear memory processing. The aim of this study is to explore whether the sleep aid melatonin, when administered prior to circadian misalignment, will rescue REM sleep and recover fear inhibition processes. This study will provide important insight into the relationship between REM sleep and processes critical for treatment and recovery from Posttraumatic Stress Disorder (PTSD).

This is a cluster crossover trial to determine whether fluid therapy with a buffered salt solution (Plasmalyte-148) reduces the time to resolution of acidosis compared to 0.9% sodium chloride (saline) in critically ill patients presenting to the emergency department with diabetic ketoacidosis (DKA). • We hypothesise that the use of PL as fluid therapy in these patients will lead to earlier resolution of acidosis and avoidance of hyperchloraemia, thereby reducing morbidity and length of stay

When we eat may be just as important for health and well-being as what we eat. The overall aim of this observational study is to examine patterns of eating (i.e. frequency, timing and content of meals and snacks), physical activity, sleep and mood and how these behaviours interact in Australian adults aged 18 to 65 years. The lifestyle behaviours will be assessed using a Smartphone food diary and established questionnaires, and a detailed follow up (including objective measures of health outcomes) will be undertaken in a subgroup of participants. This project will provide us with important information that can be used to develop healthy eating messages.

Intubation speed by ‘experts’ in a simulated model of cardiac arrest with continuous chest compressions. This study will examine the ability of intubating specialists to follow current guidelines and intubate during continuous CPR, which is rarely seen in clinical practice. This is a manikin based study, with practicing anaesthetists as participants for an ideal model. Participants will use either a direct or videolaryngoscope to intubate, and will then use the alternate device in this crossover study.

The purpose of this study is to examine a new clinician administered care model addressing fear of cancer recurrence in breast cancer survivors. Who is it for? You may be eligible for this study if you are aged 18 or above and have undergone curative treatment for stage I to III breast cancer. Study details All participants in this study will partake in a 10 minute educational intervention which provides patients with advice regarding their fear of cancer recurrence. The program is delivered by their usual breast oncologist at a routine follow-up clinic. All participants will be asked to complete three questionnaires, one prior to the follow-up appointment, and again at 1 week and 3 months after the follow-up appointment. Additionally participants will be invited to participate in an interview about their experiences in participating in this program. It is hoped that this research provide some preliminary evidence that the intervention is effective in preventing the development of high fear-of-cancer-recurrence in breast cancer survivors.

Current treatment of heart attacks focuses on the large arteries of the heart where the blockages can be seen with injection of X­ray dye (contrast). However, the small arteries of the heart are increasingly recognised to play a key role in affecting the outcome of patients after heart attacks. The function of the small arteries of the heart may be worsened by heart attacks and by balloons and stenting procedures to unblock the main arteries. It can also be worsened by life style factors like smoking and high cholesterol. The index of microcirculatory resistance (IMR) is a new measure and has been shown to be a highly precise and reliable method of assessing the function of the small arteries of the heart. However, it is unclear if this new measure applies to patients after non-ST elevation acute coronary syndromes (NSTE-ACS), which is the most common form of heart attacks presenting to hospitals. This study aims to use IMR to examine ways to improve function of the small arteries of the heart in patients after NSTE-­ACS. We plan to primarily examine the effects of 2 different blood thinners (anti-platelet agents), clopidogrel and ticagrelor, on the IMR after NSTE-ACS. Both drugs are approved treatments for NSTE­-ACS. All participants will receive standard medical care as determined by their treating doctors.

Anxiety disorders are among the most common mental health problems experienced by children and adolescents. Children with hearing loss often experience greater anxiety symptoms than children without hearing loss. Cognitive behavioural therapy (CBT) has a strong evidence base for being efficacious and useful in treating anxiety in children. However, most children with anxiety do not engage in child-focused CBT or mental health treatment of any kind due to reasons such as financial cost and parental perceptions of their child being stigmatized by others. This has led to an examination of parent-focused interventions, such as Fear-Less Triple P, in reducing children’s anxiety as a way of addressing these barriers. There has, however, been no research into specifically examining parent-focused interventions in reducing anxiety in anxious children with hearing loss. Given this gap in the literature, the current research project aims to examine the efficacy of a parenting intervention (the Fear-Less Triple P workshop) with parents of anxious children and have hearing loss. A naturalistic waitlist group will be built into the study design to allow comparison of this group with the active Fear-Less workshop.

1. What is the research project about? Babies can be born with different degrees of hearing loss. Hearing aids are generally provided to them to help them hear well. Whilst we know that hearing aids help babies with moderate or greater degrees of hearing loss, we do not know whether hearing aids are helpful for babies with mild hearing loss, even though they are often offered to these babies. This is a pilot study that will help us plan for a bigger study in the future to increase knowledge about whether hearing aids help babies with mild hearing loss.Hearing aids can help babies with moderate or greater degrees of hearing loss to hear. However,, but we do not know whether they help babies with mild hearing loss even though they are commonly offered hearing aids. . This study is a first step to collect information that we hope will lead to a larger study to helps us answer this important question. 2. Who is running the project? The study is run by a team based at the Murdoch Children’s Research Institute (MCRI) in Melbourne and the National Acoustic Laboratories (NAL) in Victoria, New South Wales and Queensland. MCRI is the research institute affiliated with the Royal Children’s Hospital in Melbourne and is the largest child health research institute in Australia. NAL is the research arm of Australian Hearing, which is responsible for looking after the hearing health of all children with hearing loss in Australia. The study is funded by a philanthropic grant from the Garnett Passe and Rodney Williams Memorial Foundation.

Probiotics are defined as live microorganisms which when administered in adequate amount confer a health benefit on the host. The probiotic efficacy relies on their ability to survive in the digestive system and proliferate in the gut. The aim of this study is to investigate the survival of LcS in the intestine of healthy Australian adults after intake of fermented milk (Yakult). A single-arm, open-label study involving 25 otherwise healthy adults will examine the recovery of live culturable bacteria from faecal samples following 7 and 14 days of Yakult ingestion.

The study will have a pretest-posttest design and will be conducted on community-dwelling people with SCI. Participants will train a partially paralysed muscle group for six weeks. The purpose of this study is to determine changes in muscle architecture of partially paralysed muscles in response to strength training. An understanding of the underlying causes of strength increases in people with spinal cord injury will help inform the development and provision of rehabilitation programs. Muscle architecture will be measured before and after training using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The participants will receive a strength-training program for the target muscle group three times a week for 6 weeks which will consist of both isometric and concentric contractions. We hypothesise that strength training of partially paralysed muscles will increase muscle physiological cross-sectional area