ANZCTR search results

Fungal infections after receiving a bone marrow transplant is lethal and requires costly anti-fungal treatment . This study will give immune cells to transplant patients to fight the infection. We hope that these immune cells will shorten the amount of anti-fungal drugs required and improve patient outcomes.

This study is a Randomised Controlled trial (RCT) of an online, schools-based, mental health service called Smooth Sailing. This study will evaluate the effectiveness of Smooth Sailing in comparison to a waitlist control group. Smooth Sailing is a service designed to screen and assess the levels of depression and anxiety among secondary high school students. Using a website, students register to the service and then complete an assessment of their mental health symptoms which consists of brief, clinically validated questionnaires. The service then allocates each student to one of five steps for which different online activities are prescribed. The school counsellor is automatically notified by the service when students are allocated to the highest steps, which indicate the most severe symptoms or if or if they report thoughts that they would be better off dead or harming themselves In some way. The school counsellor then follows up with these students in person. This 12-week trial aims to evaluate the effectiveness of the Smooth Sailing service for improving help-seeking as well as reducing symptoms of depression, anxiety, and distress among secondary school students. It is hypothesised students receiving the Smooth Sailing service will report improved help-seeking, reduced distress, depression, and anxiety, when compared to the waitlist control.

This is a commercial study, to assess the effectiveness and dose response of Testofen on muscle strength, endurance and stress markers in exercising females.

The aim of this study is to determine whether midwives can contribute to the provision of contraception, particularly the insertion of Implanon NXT®, in the Australian hospital setting in the immediate postpartum period.. Participating midwives will be provided with training regarding contraceptive counselling, Implanon NXT® insertion, and how to implement this in the postpartum setting. It is standard practice for midwives to insert contraceptive implants in the postpartum period in other countries, however this is most commonly done by medical officers in NSW hospitals, and is not current practice by midwives. It is hypothesised that providing contraceptive training will increase provision of contraception in this setting, and improve confidence of midwives in providing contraceptive counselling and implant insertions. Providing this training to midwives may influence attitudes to contraception provision in this setting, but it is not possible to hypothesise the direction of this change.

This study aims to determine the repeatability of two investigational instruments ( the Lenstar LS 900 and the Triton Swept-source OCT). The instruments are used in optometric research to assess the length of the eye and the thickness of the vascular layer of the eye ( the choroid). To achieve this we wish to take measurements using the instruments over two separate days. The study sample will include a minimum of 15 participants to up to 40 participants with or without refractive errors, we wish to assess the repeatability of the instruments by taking two sets of measurements on two different days.

Preliminary findings suggest aspirin may slow or reduce the rise in core temperature during exercise, improving exercise capacity in individuals with multiple sclerosis (MS). These findings are questionable as the mechanism of action of aspirin does not play any role in active heat production. Cooling interventions like cold water immersion prior to exercise can mitigate heat-related reductions in exercise capacity in individuals with MS. However, many of these interventions are impractical. This project aims to assess the effectiveness of aspirin and skin cooling with a cold water spray on exercise capacity and postural sway in the heat in individuals with MS. It is hypothesised that in individuals with MS, cooling the skin with a cold water spray during exercise, but not ingesting aspirin prior to exercise, will improve exercise capacity and reduce postural sway in the heat.

Heart attack is a major cause of death within the Australian community. Cholesterol blockages in the coronary arteries (the vessels supplying oxygen & nutrients to the heart muscle) are typically responsible for the heart attacks and best seen on a specialized X-ray test that involves injecting dye into these arteries (coronary angiography). Surprisingly, in approximately 10% of heart attack patients, angiography does not show any significant cholesterol blockages. This group of patients is referred to as MINOCA (Myocardial Infarction with NonObstructive Coronary Arteries). The question then arises as to what caused the heart attack in these MINOCA patients? Potential causes include cholesterol plaque rupture, coronary artery spasm or abnormal constriction of the coronary microscopic vessels (coronary microvascular dysfunction). The aim of this study is to determine how often patients with MINOCA have evidence of cholesterol plaques or coronary microvascular dysfunction. Understanding how often these occur and their relationship to heart muscle damages (as seen on cardiac MRI) and symptoms will assist us in developing future treatments for this condition. The microvascular dysfunction assessments and plaque composition assessments will be performed following the standard coronary angiogram procedure and cardiac MRI will be performed within 5 days of the initial admission. All participants will be given informed consent prior to the study participation.

The purpose of the study is to investigate the effects of short-term imposed blur (optical defocus) on central and peripheral length and the vascular layer of the eye ( choroid) that may help to predict that an optical intervention can control myopia progression.

With an increasing prevalence of people with CHD, combined with a lack of data to characterise the full spectrum of cases or long-term outcomes, there is a critical need to understand the burden of CHD in Australia and New Zealand. The development of a Regional Registry can generate the knowledge needed to better understand the true diversity of outcomes and burden of the entire spectrum of CHD across the lifespan. This information has the potential to drive policy development for the optimal management of both paediatric and adult populations to achieve better health outcomes. This Registry will aim to capture data on patients diagnosed with a congenital heart defect at any age and will be conducted in congenital heart units throughout Australia and New Zealand. It will collect data from medical records on epidemiology, CHD history, clinical course, symptoms and burden of disease from all participants who were born with a CHD. By participating in the Registry, hospitals will be able to provide patients with CHD an opportunity to contribute to the body of knowledge about the burden of CHD. This Regional CHD Registry will become a mandatory tool to provide best care to a growing population.

The purpose of this study is to see whether the use of a particular type of PET scan will improve detection rates of cancer, and improve treatment management. Who is it for? You may be eligible for this study if you are aged over 18 and have been referred for radiotherapy after a prostatectomy. Study details All participants in this study will be required to undergo a PET/CT scan and a diagnostic CT Chest/Abdomen Pelvis You will also be asked to fill out a quality of life Questionnaire. before and after commencing radiotherapy. You will be reviewed as part of your routine care with a routine blood test which will monitor your PSA levels at these visits you will be asked to complete a quality of life Questionnaire. It is hoped this research will determine if the use of PET scanning in treatment planning and how it influences radiation treatment planning in patients will improve treatment outcomes for patients with prostate cancer.