ANZCTR search results

This study assesses the effectiveness of pancreatic surveillance protocols in identifying early-stage pancreatic cancer among high-risk individuals. Significant emphasis is also placed on assessing the psychological perception of cancer surveillance and understanding its impact on high-risk populations. Who is it for? You may be eligible for this study if you are have relatives with history of PDAC, or high-risk pathogenic variants within the family. Study details Participants will undergo monitoring via endoscopic ultrasound or MRI to detect changes in the pancreas, for a period of 10 years. Participants will be asked to complete an eligibility questionnaire, an enrolment questionnaire and then follow-up questionnaires annually which include updates to the participant’s medical information, relevant risk factors associated with pancreatic cancer, and assessments to determine quality of life, as well as cancer risk perception and worry. It is hoped that findings from this study will help improve the prognosis of pancreatic cancer by diagnosing precursor lesions or cancer in its early and asymptomatic stage, when surgery provides the best chance for a cure.

CARGo is a Phase IIb single arm efficacy study of oral carbamazepine in women to treat uncomplicated Neisseria gonorrhoeae (NG) infection. The study applies a window-of-opportunity design where participants will receive carbamazepine whilst awaiting the results of a standard of care NG test. Asymptomatic women who have been identified as a sexual contact of a person confirmed to have gonococcal infection will be targeted for recruitment

This study will use electronic medical records from the Austin Health database to evaluate the outcomes and complications in patients undergoing liver transplant surgery who receive an IV dextran infusion. These results may be used to aid prognostication of post-operative liver transplant patients, as well as identify, and therefore modify, factors that may predispose patients to poorer post-operative outcomes and ultimately reduce overall morbidity and mortality in this patient cohort.

Participants in both groups will receive quality care by a physiotherapist based on the best current research evidence. This care involves two telehealth consultations, approximately 5 weeks apart, with a physiotherapist via Zoom software. During these sessions, participants will receive an individualised strengthening exercise program for the knee comprising 4 leg exercises. In addition to the exercise program, participants will be randomly assigned to recieve either of two different ways a physiotherapist provided information about osteoarthritis and its management, i) information provided verbally or ii) information provided verbally and supported by an online resource. We hypothesize that the use of the online resource will enhance pain and/or physical function outcomes at 24-weeks in comparison to information provided verbally only.

This randomised controlled pilot trial will test the feasibility, acceptability, preliminary efficacy and cost-effectiveness of a digital health intervention (RecoverEsupport) among breast cancer patients undergoing surgery. Who is it for? You may be eligible for this trial if you are aged between 18 years or older, have been diagnosed with breast cancer, and are planning to undergo mastectomy with or without a breast reconstruction, or a breast reconstruction (following a previous mastectomy) Study details Eligible patients will be recruited at the pre-surgical consultation or the peri-operative clinic. Consenting patients will be asked to complete surveys at: baseline, post-surgery during the hospital admission, and post-discharge (1- and 3-months post-surgery). Following completion of the baseline survey, patients will be randomly allocated to the control group (receiving standard care), or the intervention group (receiving the RecoverEsupport program): RecoverEsupport is a digital health intervention aimed at improving adherence to patient-led ERAS recommendations. The intervention includes an online program (accessible to patients) and a series of prompts for patients and clinicians to encourage continued self-management. It is hoped this intervention will assist in overcoming some of the barriers to implementation of the ERAS pathway. If effective, the intervention could be rapidly rolled-out at scale and adapted for other surgical patient groups.

This is a open label pilot randomized controlled trial to evaluate multi-disciplinary integrated team approach to electronic discharge summaries. Historically its the doctors who traditionally make the discharge summaries. This project will evaluate and compare the discharge summaries made by the nursing and medical staff compared to the conventional medical only discharge summaries.

The purpose of this study is to assess the feasibility of using a tri-axial accelerometer (ACTi Graph) to measure the level of activity performed by patients in hospital following open heart surgery at the Victorian Heart Hospital. This study will help identify the feasibility of recruiting patients and collecting data using the ACTi Graph device, as well as collect preliminary information about physical activity levels and outcomes for patients following open heart surgery. Results will assist in the planning of future research into the optimisation of physiotherapy management in patients undergoing open heart surgery.

Osteochondral lesion in talus can be challenging to treat leading to ongoing pain and loss of function. This study aims to investigate the efficacy of viable cartilage allograft for osteochondral talar dome lesions. The study hypothesis is: In patients with talus osteochondral lesions, viable cartilage allograft can improve patient pain and function.

• We are studying patients with anaemia who have had trauma surgery. • Anaemia is a deficiency in the number or quality of red blood cells. • Red blood cells carry oxygen around the body, using a protein called haemoglobin. • Anaemia exists when either the level of red blood cells or haemoglobin is lower than normal. • A treatment, involving a single intravenous (IV) injection of iron medication in hospital prior to discharge, is expected to improve the body’s ability to better correct anaemia. • This could result in a faster recovery, but we don’t not know if the IV iron injection truly works in people following trauma – this is why we are doing this trial.

This study aims to assess the effectiveness of a culturally adapted avatar-based education app in improving coronary heart disease knowledge and uptake of cardiac rehabilitation among Chinese-speaking patients with acute coronary syndrome (ACS) admitted to hospitals. We will conduct a randomised, controlled trial to compare an avatar-based education app to usual care. Adults admitted to Westmead, Royal Prince Alfred, and St George Hospitals with a diagnosis of ACS in the current admission will be invited to participate. Participants randomised to the intervention group will be given a link to download the app to their smartphone or tablet. During the study period, participants will independently work through the app's six modules, which are based on the Heart Foundation’s Six Steps to Cardiac Recovery. We hypothesize that the application will improve Chinese-speaking ACS patients disease-related knowledge, self-management behaviours and health-related outcomes such as disease recurrence, mortality, and quality of life.