ANZCTR search results

This study explored whether a single-session online Mindfulness-Based Art Therapy Doodling Intervention could support the wellbeing of school teachers in regional Victoria. The two-hour workshop guided participants through mindfulness and creative doodling activities designed to enhance self-awareness, self-compassion, and classroom confidence. The purpose was to evaluate whether this simple, accessible approach could help prevent burnout and strengthen internal coping resources. We hypothesized that teachers would show improvements in mindfulness, self-compassion, and teaching self-efficacy after participating in the session.

This is a Phase 1, open-label, 4-period, period-balanced trial in healthy participants. The trial will investigate the relative bioavailability of 2 formulations (IR tablet and minitablet) of JNT-517 along with the effect of food on the pharmacokinetics of JNT-517. All participants will receive a single dose in a fasted or fed (high fat meal) state.

This study aims to investigate how different amounts of eccentric lunge walking affect physical fitness, muscle strength, balance, mental health, and overall quality of life in adults aged 60 to 80 who are less physically active. We believe that participants who do a higher dose of this exercise will show greater improvements in these health areas compared to those who do a lower dose.

The problem – inpatient harm. Preventable adverse events in Australia’s hospitals are a major safety issue. The magnitude of preventable adverse events coupled with failure to escalate care of deteriorating patients provides strong evidence that existing nursing assessment and management frameworks are not fit-for-purpose. Research is needed to inform the development of an intervention to enhance nursing practice to (a) prevent adverse events, (b) optimise patient experience and (c) improve clinical communication. The aim of this project is to design, implement and evaluate the effect of HIRAID® Inpatient on patient, staff and health service outcomes.HIRAID® Inpatient will be an adaptation of our validated and highly successful emergency nursing framework – HIRAID® (History including Infection risk, Red flags, Assessment, Interventions, Diagnostics, reassessment, and communication).

In this randomised, double-blind, placebo-controlled study, 80 women aged 50 to 70 years experiencing comorbid depressive symptoms and sleep disturbances will be randomly assigned to receive a saffron extract (14mg twice daily) or a placebo for 12 weeks. Changes in depressive symptoms and sleep quality will be examined over time. Moreover, changes in self-evaluations of physical appearance and self-esteem will be examined. Using photos of participants, a skin age application using AI technology will also be used to evaluate changes in facial skin age over time. It is hypothesised that compared to the placebo, saffron supplementation will be associated with greater reductions in depressive symptoms, sleep disturbances, self-esteem and self-evaluations of physical appearance. Moreover, a reduction in facial skin age is also predicted.

This pilot trial will explore the acceptability, feasibility and outcomes of a blended care group program which combines 8 group therapy sessions with a smartphone app, called MyNewWay. The purpose is to evaluate the short-term outcomes of this new blended care intervention for adults with anxiety disorders.

This study aims to evaluate the diagnostic performance of PB-CT in a real-world clinical setting and compare the scans to the standard of care (mammography). Who is it for? You may be eligible to join this study if you are a woman aged 50 - 70 years old, have had a mammogram in the past 6 months with no detected breast cancer and have no metal clips in your breasts. You will need to be able to go to the ANSTO facility in Clayton Victoria and able to lie face-down for a couple of minutes. Study details All participants who meet the eligibility criteria in this study will undergo Propagation-Based Phase-Contrast CT (PB-CT) (intervention) for breast imaging. After the intervention, image quality metrics of the scan will be assessed and participants will be surveyed regarding the comfort of the scan. It is hoped that this research project will help us understand how acceptable this new test is for patients, provide imaging data sets to teach radiologists how to read PB-CT scans, and allow diagnostic quality assessments to be made. Together, this research will help guide future improvements in breast screening and diagnostic imaging for cancer detection and treatment planning.

This study aims to assess the feasibility of a mediterranean meal box for people living with Huntington's disease and their family. We hypothesise the meal box will be safe and feasible for this community. We also expect it to improve cooking behaviours and quality of life.

What is the purpose of this research? The PROXIMITY study is a national, multi-site research project aiming to better understand how prostate cancer develops, progresses, and responds to treatment. By collecting clinical data, patient-reported outcomes, and optional biological samples, the study seeks to improve the care and outcomes of men with prostate cancer. The study follows a master protocol, with flexible sub-studies introduced over time to address specific research questions. This registration describes the overall PROXIMITY study and its first two sub-studies: HOROSCOPE and PROCAP. Who can take part? You may be eligible to participate if you are aged 18 years or older and have been diagnosed with prostate cancer. Each sub-study will have its own eligibility criteria to determine who can take part. What’s involved? If you agree to take part, depending on your eligibility and consent for specific sub-studies, you may be asked to: Allow researchers to access your prostate cancer-related medical records Complete online surveys about your health, symptoms, and quality of life Optionally provide blood or tissue samples, if available via your treating team Participation in the PROXIMITY master study allows for the possibility of being invited to future sub-studies over the 10-year study period. You can choose to join any sub-study you are eligible for given they would be available at your treating site. What are the sub-studies about? HOROSCOPE investigates how changes in specific DNA repair genes (such as BRCA1, BRCA2, and other homologous recombination repair genes) affect treatment outcomes in patients with metastatic or high-risk localised prostate cancer. This involves retrieving archived tissue for genomic testing—no extra visits or procedures are required. PROCAP looks at how cultural background and language preferences influence prostate cancer care. It involves completing surveys over a 2-year period to understand how different patient experiences and backgrounds may impact care and quality of life. Please note: All PROXIMITY sub-studies are observational only. No treatments are provided through participation. Why is this research important? Your participation will help researchers understand the diverse experiences of men with prostate cancer, including how different treatments affect quality of life. The findings may lead to more personalised, culturally responsive care in the future.

This is a phase 1, open-label, study to evaluate the safety, pharmacokinetics, and pharmacodynamics 225 IU GB-hMG over 7 consecutive days in healthy premenopausal women. Up to twenty eligible, healthy volunteers will receive one (1) subcutaneous (SC) injection of 225 international units (IU) per day for seven (7) consecutive days to evaluate the safety, pharmacokinetics, and pharmacodynamics of GB-hMG.