ANZCTR search results

This study aims to investigate the effects of a 4-week Expiratory Muscle Strength Training (EMST) program on speech and swallowing in people with Parkinson’s disease (PD) who have undergone Deep Brain Stimulation to the subthalamic nucleus (STN-DBS). While EMST has shown benefits in PD populations, its impact following STN-DBS has not yet been explored. Twenty-four eligible participants will complete pre- and post-intervention testing, with home-based EMST sessions conducted five times per week. Outcome measures will include speech, voice, and swallowing assessments, alongside quality of life and cognitive screening. Results will be analysed using linear mixed models to evaluate the effectiveness of EMST in improving communication-related outcomes in this population.

Community-based dance programs may offer multiple benefits for Autistic children, including improvements in motor, social, and cognitive functioning. However, rigorous empirical research, particularly randomised controlled trials, evaluating these benefits remains limited. This randomised controlled trial (RCT) aims to assess whether participation in the community-based dance program, AllPlay Dance, improves children’s movement abilities, social functioning, thinking skills, emotional and behavioural functioning, as well parental stress compared to a treatment-as-usual waitlist control condition, from pre- to post-intervention. Additionally, we will assess the acceptability and feasibility of the AllPlay Dance program post-intervention for families and buddies, as well as whether families continue participating in community-based dance programs and how they describe their experiences at follow-up.

Durable left ventricular assist device (LVAD) is a form of mechanical support used in patients with end-stage heart failure as a bridge to heart transplantation. The technical challenges in heart transplantation in patients with an LVAD are often associated with adhesions around the heart and great vessels. Coseal is a commercially available product which forms a hydrogel that inhibits adhesion formation. This study aims to investigate the effect of Coseal spray application at the time of LVAD implant on the adhesions that are encountered at the time of OHTx.

Middle meningeal artery is an important part of the trigeminovascular system and may be important in migraine pathophysiology. By blocking blood flow to this artery migraine headaches may be reduced in frequency or severity.

The safety and levels of PTC844 tablets administered under fasted and 2 fed conditions (standard meal and high-fat meal) will be assessed in an open label (no blinding), 2 arm, single fixed sequence, and 2 period cross-over design with each arm in healthy participants.

Perioperative anxiety is common and has implications for an individual’s recovery from surgery and general health outcomes. We will measure anxiety preoperatively and then assess opioid analgesia requirement and recovery (measured by length of hospitalisation)post operatively. We hypothesise that more anxious patients will have more pain after surgery, with poorer recovery and perhaps longer hospital stay.

Non-invasive ventilation (NIV) uses a breathing machine and a mask to help people with sleeping and/or breathing problems. Using NIV at night can reduce tiredness, hospital visits, and improve quality of life. In this research study, people with sleep and breathing problems who are having difficulties with using their non-invasive ventilation (NIV) will be randomly allocated to one of three groups: 1) night time hospital stay to monitor sleep patterns while using NIV; 2) detailed virtual monitoring of sleep patterns while sleeping at home using NIV; 3) basic virtual monitoring of sleep patterns while sleeping at home using NIV. The aim of this research study is to determine if there is a difference between these three ways of monitoring sleep patterns and whether they improve the amount of time people use NIV while sleeping.

FRONTIER-APX is an Australian led trial in the Asia-Pacific region (FRONTIER-AP) which seeks to answer an important clinical conundrum on the optimal treatment approach for patients with clot in medium sized vessels (MVO) in the brain. Following the results of multiple randomized clinical trials some states in Australia have structured clinical pathways for treatment of patients with large vessel occlusion (LVO). Such knowledge does not exist for MVO. In 2025, several trials on medium vessel occlusion reported no superiority of thrombectomy over standard care. The DISTAL trial recruited patients with occlusion of the second to fourth order branch of the middle cerebra artery, first to third order branch of the anterior cerebral artery and posterior cerebral artery. Analyses of the data suggest that equipoise remains for patients with occlusion of the second to third order branch of the middle cerebral artery (M2-3) but not for the anterior or posterior cerebral arteries. These lessons have been adapted into the FRONTIER-APX trial and is reflected in the inclusion and exclusion criteria.

Fear of pain following dental surgery can cause anxiety and contribute to dental phobia, particularly in relation to dental extractions. In recent years, researchers have explored new methods to reduce postoperative pain associated with these procedures. The purpose of this study is to investigate whether a polychromatic light-emitting diode (LED) device, which emits visible red and near-infrared light, can help reduce pain during the recovery period. This study is being completed as part of Dr Jessica Zachar’s Doctor of Philosophy (PhD). This research is being conducted and sponsored by The University of Queensland.

The purpose of this study is to gain first information on the safety and performance of the LivIQ leadless pacemaker system and to inform the preparation of procedures, workflows, and optimized device training for a subsequent international pivotal study investigating the LivIQ system. Its objective is to determine preliminary safety and product performance of LivIQ and understand the implantation experience with LivIQ from implanters’ perspective.