ANZCTR search results

This study aims to assess if a device called ‘Preemietest’ is more accurate than the current assessment for maturity after birth, called the Ballard score, in determining gestational age. The Preemietest is a light-based device that assesses the baby’s gestational age by placing it on the sole of the foot for a few seconds. The device will provide us with an instant result, and this will be compared to the early dating scan to assess the accuracy of the Preemietest.

This study aims to explore the acceptability of combining robotic training using KinArm Exoskeleton device and functional training. By exploring the acceptability of this training protocol, it would provide the necessary steps to improve the implementation of a robotic training for people with arm and hand weakness after stroke. Also, we would also aim to investigate if combining robotic and functional training for 10 sessions can improve arm/hand strength and function of people who had stroke.

To determine if arterial reflection measures can be used as a risk and monitoring tool for heart disease in Australians with chronic kidney disease. We hypothesise that arterial reflections measures are correlated with current heart disease risk measures.

Ankle osteoarthritis is a serious health problem that causes disabling pain and limits performance of daily, recreational and occupational activities; however, little is known about how to manage it. The aim of this study is to establish the feasibility of conducting a full-scale randomised controlled trial investigating the addition of foot orthoses and education to usual care, compared to usual care alone for people with ankle osteoarthritis, and to collect quantitative and qualitative data to inform a future RCT. Key feasibility outcomes include consent rate, participant attendance at initial orthoses and education appointment, intervention fidelity and rate of completion of 3-month outcome measures. Findings from this study will improve the management of ankle osteoarthritis by establishing the feasibility of running a full-scale randomised controlled trial to investigate foot orthoses and education in this population.

A Phase 1, First-in-Human, Single and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral administration of RTX-101, RTX-010 and RTX-111 in Healthy Subjects. The current study is the first clinical co-administration of combinations of RTX-101, RTX-010 and RTX-111 to be conducted in healthy adult subjects. The study includes Part 1A: single ascending dose (SAD) and Part 1B: multiple ascending dose (MAD).

This early clinical study is being conducted to understand how a new intravenous (IV) form of cannabidiol (CBD), called IPI-201, behaves in the body and how well it is tolerated when given to healthy volunteers. IPI-201 is designed to provide a rapid and precisely controlled dose of CBD through an IV infusion, which may be useful for managing acute pain or other short-term conditions in future patients. In this study, small groups of healthy adult males will each receive a single IV dose of IPI-201 at different strengths, given over 15 minutes. Researchers will carefully monitor safety, check for any side effects, and measure CBD levels in the blood over time. The results will help determine safe dose ranges and how quickly the body absorbs and clears IPI-201. No placebo or comparison drug will be used in this study.

Exposure to extreme weather events significantly impacts mental health, leading to higher rates of anxiety, depression, trauma, substance use, and suicide. The focus of research to date has primarily been on post-exposure mental health recovery, with less attention on protective factors and positive wellbeing outcomes, and preparation for exposure to extreme weather events. To address this, we are implementing a community-based, co-led intervention that builds resilience and mental wellbeing, tailored to the specific needs of rural populations and local communities. This evidence-based approach has been shown to reduce psychological distress, increase community cohesion, and enhance preparedness and coping skills. By empowering community members to lead and adapt the program to their local context, we aim to create sustainable, long-term solutions to mitigate the mental health impacts of future environmental threats.

This is a prospective randomised trial investigating the immunological effects of two different RSV vaccines in older adults aged 60 years and above. Participants will be randomised to receive a single dose of either the Abrysvo or Arexvy RSV vaccine. Alongside standard antibody and cell mediated immunity assays, detailed exploratory systems biology assays (transcriptomics, epigenetics, lipidomics, metabolomics) and flow cytometry will be performed to investigate the broad immunomodulatory effects of RSV vaccination.

This study aims to explore the perceptions of men with prostate cancer (PCa) and high-risk biochemical recurrence (BCR) regarding the risk of breast-related side effects, including gynaecomastia, from treatment Who is it for? You may be eligible for this study if you are an adult male with prostate cancer. Study details All participants in this study will attend a single one-hour interview which will explore their thoughts regarding the risk of side effects from treatment and will include a choice experiment. This choice experiment will involve the participant making a series of decisions based on particular scenarios. It is hoped this study will help explore the trade-offs patients are willing to make between breast-related side effects, other quality of life (QOL) impacts and cancer control. Note: this brief summary is intended for lay audience.

Oral food challenges (OFC) are the gold standard tool for diagnosis of allergy and acquisition of tolerance but are not routinely performed in adolescents. These have the potential to positively impact mental health, quality of life and reduce risk-taking behaviours, in addition to ensuring accurate diagnosis. We will undertake a multi-centre prospective study of adolescents with a previous diagnosis of food allergy to investigate the impact of oral food challenges on the proportion of adolescents who enter adulthood with a current food allergy diagnosis (and proportion who were “de-labelled” i.e. proven to be no longer allergic) and impact on anxiety, quality of life, confidence in managing food allergy and risk-taking behaviours. We hypothesise that using OFCs for adolescents at the time of transition to adult care will reduce the number of adolescents entering adulthood with a food allergy diagnosis, reduce risk taking behaviours, psychological impact and costs for patients, families and the healthcare system.