ANZCTR search results

The aim of this study is to look at how much energy the body uses to digest, process and store the food that is eaten after a meal (referred to as meal -induced thermogenesis) and if there are differences between ethnicities. Understanding how the body uses energy may help us towards explaining observed differences in body composition (fat and lean mass) between people of Asian and Caucasian ethnicities and susceptibility of developing chronic diseases. The hypothesis is Asians will have a lower meal induced thermogenesis compared with Caucasians.

This study aims to compare the effects of a 12-week high-intensity interval training (4x4 HIIT: 4 x 4min at 85%-95% max HR with 3 min of rest) on brain and systemic vascular function in healthy late perimenopausal women against an energy matched moderate-intensity interval training ( 6.5x4 MIIT: 4 x 6.5min at 65%-75% max HR with 3 min of rest)) and non-exercising time control group. This will be investigated as a randomized controlled trial at the University of Queensland. In total we hope to recruit 36 participants to be randomized into either a HIIT, MIIT or a time-control group. Measures of brain and peripheral vascular function, arterial stiffness, hormone levels, vasomotor symptoms (hot flushes), cardiorespiratory fitness and body composition, will be taken prior, during, and following the intervention. We hypothesize that the HIIT group will produce the greatest improvements in cerebrovascular and peripheral vascular measures, when compared to the MIIT and time control group. The findings from this investigation will inform practitioners about how to optimise targeted exercise therapies for vascular disease prevention in women undergoing menopausal transition.

This study is a single-case experimental design (SCED) study with longitudinal follow-up aiming to evaluate the therepeutic benefits for individuals with neuromusculoskeletal impairments participating in a self-selected, performance-focused Para-sports training program. Participants involved in this project are currently enrolled in the ParaSTART (service) program and will undertake structured training in the sport of their choice and will be closely monitored in relation to sport-specific performance, psychosocial responses, fitness, health, independence and well-being. In SCEDs, each participant serves as their own control, with responses monitored during active training periods and recovery periods. SCED outcomes will demonstrate how self-selected sports participation affects health, functional independence and quality of life. Following the SCED, participants will be encouraged to continue training and monitoring for as long as they wish (ongoing service). This longitudinal follow-up is consistent with the current ParaSTART ( model which has run continuously since 2016. It is believed that participating in a performance-focused sports training program for a long period of time will improve not only the participant's ability and sporting performance, but also have benefits to their health, fitness, functional independence and mobility and psychological health and wellbeing.

Rationale: To increase uptake of HIV testing by distribution of HIV self-testing using a social network-based approach. Purpose: To examine the effectiveness of SNA in distributing HIV self-testing kits among MSM. Study design: Each test promoter will then receive four HIV self-test kits via mail, one for himself/themselves to use and remaining three for him to distribute to his social network or sexual partners, preferably overseas-born MSM. Test promoters will be required to distribute the HIVST kits to his social network or sexual partners within 3 months. All participants will be required to complete a post-HIV self-test survey and report their test result.

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most discussed health topics on social media, with an increasing rate of individuals self-diagnosing based on online content. However, some of the content consists of misleading or misrepresentative symptom descriptions, which may contribute to misdiagnosis, overidentification, and unnecessary distress. This study aims to examine the impact of different types of ADHD-related TikTok posts (personal anecdotes vs. awareness campaigns) and the accuracy of symptom descriptions (evidence-based vs. misrepresentative) on participants' perceptions, emotions, and self-diagnosis intentions. It is hypothesised that personal anecdotes will evoke higher intentions to self-diagnose, internalized stigma and emotional engagement, but lower intentions to seek an official diagnosis and perceptions of credibility compared to awareness campaigns. Further, content featuring misrepresentative symptoms is hypothesised to lead to higher intention to self-diagnose, stigma, and stronger emotional responses. Interaction effects are anticipated, with personal anecdotes containing misrepresentative symptoms eliciting the highest intention to self-diagnose, stigma, and emotional response, while awareness campaigns containing evidence-based symptoms are expected to result in the highest intention to seek an official diagnosis and credibility. Given the increasing influence of social media on health perceptions and self-diagnosis behaviors, this study will provide valuable insights into how different types of ADHD-related online content affect individuals' understanding and decision-making. The findings can contribute to discussions on responsible health communication, misinformation, and the potential risks of self-diagnosis based on social media content.

This study is being undertaken to evaluate the safety and clinical effectiveness of the M-Finity Femoral stem with a Medacta Acetabular Cup in primary total hip arthroplasty through a CT-based migration analysis. The purpose of this study is to assess the safety and clinical effectiveness of the M-Finity in a pilot study on a small patient series. This will be achieved by both assessing the adverse events and conducting a stem migration and rotation analyses on patients who are having the M-Finity device.

This study aims to investigate whether laser acupuncture can enhance brain and motor function in healthy adults. Laser acupuncture is a non-invasive technique that applies low-level laser therapy to specific acupuncture points to stimulate physiological responses. This research will compare the effects of real and sham laser acupuncture on corticospinal excitability and sensorimotor function. The findings may help improve our understanding of how laser acupuncture influences the nervous system and whether it has potential applications in rehabilitation or performance enhancement.

This study aims to investigate whether eating mussels as a snack can improve recovery and nutritional status in female endurance athletes. Participants will consume either mussels or an isocaloric portion of nuts five times per week for 12 weeks. We will measure omega-3 index, iron status, vitamin D levels, and post-exercise recovery to compare the effects of the two snacks. We hypothesise that mussel consumption will lead to greater improvements in these health markers compared to nuts. The findings may help support new dietary strategies to enhance athletic recovery using sustainable whole foods.

Young adults have the poorest diet quality out of all age groups, however, are motivated towards climate action. A potential way to improve their diets is to promote healthy and sustainable diets in this group. This study involves the development of a targeted healthy and sustainable nutrition program for young adults, and an assessment of its feasibility. It is expected that the program will have acceptable feasibility i.e. high response rates and low drop out rates.

This study is to investigate the safety, tolerability, and PK of EIK1005 in healthy participants. EIK1005 is a potent and selective inhibitor of WRN, which has been identified as a synthetic lethal target in MSI-H cells. MSI-H is a marker of cancer cells with defective mismatch repair. WRN inhibition (WRNi) acts on MSI-H cells, and thus WRNi is not expected to have an effect on healthy tissue. EIK1005 is noncytotoxic and is been considered has as potential targeted therapy in patients with MSI-H or dMMR solid tumors.