ANZCTR search results

Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes. It occurs when the body does not have enough insulin and starts breaking down fat for energy, causing ketones (acids) to build up in the blood. Currently, clinical practice for detection of glucose and ketone levels are determined at specific time points duirng a hospital admission using fingerstick blood tests, which do not detect changes as they occur. The SiBionics dual continuous glucose and ketone monitor (CGKM) is a wearable device that continuously measures both glucose and ketone levels and may allow earlier detection of DKA than current clinical monitoring methods. This study will use the CGKM to monitor people with diabetes admitted to hospital with DKA and people with type 1 diabetes who are at risk of developing DKA. By examining CGKM patterns, we aim to better understand how DKA develops and assess whether continuous monitoring could support earlier detection and improved management of DKA in the future.

This study aims to evaluate the safety and feasibility of PBM, a non-invasive light therapy, in adults with chronic kidney disease. PBM has shown potential to reduce inflammation and improve cellular function, but its use in people with chronic kidney disease has not been well studied. Participants will receive PBM treatment twice weekly for 24 weeks and will be followed for a further 24 weeks. The study will assess whether PBM can be delivered safely and whether participants can successfully complete the treatment program.

Omega-3 fatty acids are widely consumed as dietary supplements and are known to have beneficial effects on health. However, it is not well understood how different doses of omega-3 supplementation change the composition and function of human immune cells. This study will compare two doses of omega-3 supplementation in healthy adults over a 4-week period. Blood samples collected before, during and after supplementation will be used to examine how omega-3 fatty acids are incorporated into immune cells and whether this influences their biological function and responses to oxidative stress. The findings will improve our understanding of how dietary omega-3 fatty acids influence the human immune system and provide important information for future studies investigating omega-3 supplementation in health and disease.

This study evaluates whether using artificial intelligence (AI) to help emergency department doctors interpret CT brain scans can safely reduce patient waiting times. Adults with minor head injury or headache who require a CT scan will be randomly assigned to standard care or AI-supported care. The main outcome is how long patients stay in the emergency department. The study will also assess patient satisfaction and safety outcomes such as missed diagnoses.

This project is testing the safety and pharmacokinetics of single and multiple oral doses of a new drug called GBP-088. GBP-088 is being developed for the treatment of recurrent kidney stones. You may be eligible for this study if you are a healthy adult man or woman aged between 18 and 55 years old. In Part 1, participants will be randomised (assigned randomly, like flipping a coin) to receive single oral dose(s) of either the active study drug or placebo. In Part 2, participants will be randomised (assigned randomly, like flipping a coin) to receive multiple oral dose(s) of either the active study drug or placebo. It is hoped that this research will help determine the safety of GBP-088 when given to healthy men or women so that it can be tested in patients with recurrent kidney stone disease

As the population ages, the prevalence of chronic health conditions is on the rise. There is a need for early diagnosis and intervention for ageing related chronic conditions, with increased health promotion, continuity of care, and care planning to address the physical, social and lifestyle factors influencing healthy ageing. Primary care-based health assessments and care planning (led by GPs and general practice nurses) provide a personalised approach enabling coordinated care for chronic condition management with a focus on early intervention and prevention. This research will involve 12 general practices within Adelaide to support older adults (aged 65+ years) with one or more chronic conditions involved in an early intervention bundle of care. Practices will be encourage their patients to complete a pre-assessment tool, participate in in chronic condition care planning, health assessments, with recommendations for advanced care directive planning and social prescribing. General practice team members and patients involved in this project will be invited to participate in qualitative interviews and/or focus groups. This mixed methods research will evaluate implementation outcomes (reach, effectiveness, adoption, implementation, maintenance) and patient outcomes (quality of life and social connection). Findings will inform sustainability of the project and strategies for scale up to more practices and patient population groups. The project will be conducted from July 2026- July 2027 with patient recruitment and implementation of the early intervention bundle of care from July 2026-April 2027.

This study aims to compare the safety and effectiveness of delivering focused radiotherapy (stereotactic radiosurgery or SRS) in either one session or three sessions before surgery in people with brain metastases. The goal is to find out whether spreading the radiation dose over multiple sessions before surgery improves cancer control and reduces side effects. Who is it for? You may be eligible for this study if you are aged 18 or over, have a confirmed diagnosis of a solid cancer that has spread to the brain, and your medical team has recommended SRS and surgery to remove at least one brain metastasis. Study details Participants in this study will receive focused radiotherapy (SRS) before undergoing surgery to remove brain metastases. All participants are randomly allocated to one of two treatment groups: a single session of SRS, or three smaller sessions of SRS on consecutive days before surgery. Tests may include imaging scans and other routine assessments to monitor treatment effects and side effects. This research hopes to improve how we treat brain metastases and reduce long-term complications, ultimately leading to better quality of life for people with advanced cancer.

Chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD) cause a major burden in Australia, particularly following an exacerbation that can lead to emergency department visits and hospital admissions. This study will evaluate whether the ENGAGEMENT model of care can help people better manage their condition, improve quality of life, and reduce healthcare use. The ENGAGEMENT program combines support from trained nurses with a personalised action plan, telehealth consultations, electronic monitoring of inhaler use, and a mobile phone app to track symptoms and medicines. Adults with asthma or COPD who have recently experienced an exacerbation will be recruited through hospitals and general practices in Victoria. A total of 400 participants will be randomly allocated to receive either the ENGAGEMENT intervention in addition to usual care or usual care alone. We hypothesise that participants receiving the ENGAGEMENT intervention will have improved health-related quality of life, better disease control and self-management, and fewer hospitalisations and emergency department presentations than those receiving usual care.

Relative Energy Deficiency in Sport (REDs) is a condition that can occur when athletes do not consume enough energy to support their training and the body's normal functions. REDs can affect health, performance, recovery, hormones, and bone health. This study will evaluate and compare a range of existing and emerging tools used to identify athletes at risk of REDs. Participants will complete questionnaires, dietary assessments, body composition measurements, blood tests, imaging scans, and physical performance assessments during a single study visit. The findings will help determine which tools are most useful for accurately identifying REDs in athletes.

In this study we will record on video laparoscopic gastric bypass procedures whilst using a new laparoscopic instrument holder, Surgirack. This device has been approved by the Therapeutic Goods Administration (TGA) which is the Australian government organisation tasked with making sure medical devices are safe. Surgirack has been used since January 2025 over 3000 times across 10 different hospitals and by 45 different surgeons within Adelaide. Surgirack has been used in laparoscopic gastric bypass close to 200 times since January 2025. We will also record laparoscopic gastric bypass using standard instrument holders. We will then compare the videos to see if there is a difference in instrument exchange time between the two different instrument holders. We believe that instrument exchange time is significantly reduced which would then reduce operating time.