ANZCTR search results

Taurine has been shown to influence core body temperature, sweat response and blood flow regulation during exercise. However, the majority of this research has been conducted with a primary focus of understanding the physiological effects during fixed-paced trials, with limited evidence on the effects of taurine on exercise performance in the heat. As such, this study aims to determine the effects of taurine supplementation on performance, as well as perceptual and physiological responses during a 20km self-paced cycling time trial. The study will complete by 14 trained male and female cyclists, age between 18-55 who are not currently accustomed to hot environments. Participants will complete three visits, including VO2max and familiarization, and two experimental trials. Experimental trials will be conducted in a double-blind, randomized, placebo-controlled, crossover fashion and involved 4-day supplementation of either 50 mg/kg of taurine or a placebo (50 mg/kg/bm of maltodextrin), prior to the performance trial. assigned. The performance trial will involve a self-paced 20km time trial in heat (36°C with 40% relative humidity). Core body temperature, sweat rate, heart rate and perceptual responses will be assessed prior to and during the experimental trials. This research seeks to elucidate the potential effects of taurine on athletic performance in the heat.

The aim of project is to determine whether multi-component intervention in early childhood (i.e. sustained nurse home visiting from pregnancy to age 2, needs-based interventions from age 2 to school entry, early education) improves health, development and transition to school of Aboriginal children. The evaluation will utilise a mixed method design to gather administrative, parent report and standard measures as well as qualitative and audit data. Effectiveness of a program of intervention and support for Aboriginal children will be based on comparisons, adjusted for baseline differences, with an historical cohort of Aboriginal children not receiving structured intervention Population child health, development and early education data from other sources Expected outcomes of the program are to: - Improve health and development outcomes for Aboriginal children, and - ‘Close the Gap’ between outcomes for Aboriginal and non-Aboriginal children.

Many patients admitted to the intensive care unit or acute coronary care unit require medications to support their blood pressure while they are unwell.. Currently, guidelines are unclear on how safe it is the move patients out of bed when they are on these medications. At Canberra Hospital, we regularly move patients out of bed on these medications. This study will collect information on what happens to patients when they move out of bed while their blood pressure is supported as part of normal care. This will give us information that will allow us to compare information from other hospitals and better inform guidelines on what is safe to do with this group of patients.

Management of hypoglycaemia in patients with diabetes has been demonstrated to be poor, with only 15% of hypoglycaemia treated correctly in a 2018 audit at our hospital (unpublished data). We hypothesise that exposure to a brief education video on detection of hypoglycaemia, correct hypoglycaemia management and the adverse outcomes associated with hypoglycaemia will improve nurses' diagnosis and management of hypoglycaemia. Nurses will be invited to participate in the study. Participants will complete a baseline online questionnaire on their knowledge and clinical practice around hypoglycaemia. They then be directed to the online 13 minute video. One month after receiving access, they will repeat the questionnaire. Management of hypoglycaemia will then be audited for up to 12 months prior to the video intervention and 12 months post intervention to determine whether there has been any improvement in hypoglycaemia management, reduction in hypoglycaemia and reduction in adverse outcomes associated with hypoglycaemia.

We are conducting a clinical trial to evaluate the effectiveness of weight loss via a very low energy diet for people with chronic low back pain. We will evaluate the effectiveness of the intervention on low back pain and disability at 6 and 12 months. The control group will receive healthy eating advice from a dietitian. Primary and secondary outcomes will be collected at baseline, 6-, and 12 months post-randomisation. We hypothesise that those in the weight loss very low energy diet group will experience greater improvements in pain and disability.

Social media can contribute to negative body image and disordered eating attitudes and behaviours. To address this, we developed the Reshape intervention which seeks to reduce body and eating concerns and support safe and positive social media use. This study aims to evaluate the Reshape intervention compared to waitlist control in improving body image and reducing disordered eating. It also seeks to improve social media use and mitigate other related harms, such as depression.

This world-first project will (i) develop a personalised dietary approach for Crohn’s disease and (ii) identify factors that predict diet success or failure of dietary therapy. Patients will start on a wholefood, Mediterranean-style diet (Step 1), which is flexible, well-tolerated and likeable. They will have their inflammation and symptoms monitored every six weeks. Patients whose inflammation and symptoms are reduced will stay on the wholefood diet. Patients who do not respond to the wholefood diet will progress through (up to) three additional diets until their disease is well-controlled. The additional diets, which increase in prescriptiveness, are Step 2: Phase 2 of the Crohn’s Disease Exclusion Diet (CDED); Step 3: Phase 1 of the CDED; Step 4: A formulated, liquid only diet, known as Exclusive Enteral Nutrition (EEN). Each diet will be considered successful if the patient achieves a 50% reduction in measures of inflammation in poo (calprotectin) and blood (CRP). The study will also assess changes in gut bugs (the microbiota), diet satisfaction, diet intake, quality of life, and anxiety and depression scores. A detailed analysis of personal and disease characteristics, gut bacteria, and genes will be undertaken to establish factors associated with each diet’s success or failure. We hypothesise that a treat-to-target step-up dietary intervention will lead to high levels of disease response, with good adherence and patient satisfaction.

The present study is a first-in-human (FIH) study aimed to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of M102 in healthy participants and aims to investigate both single and multiple doses of M102, as well as investigate the impact of food on the PK profile of M102. Up to 80 participants are planned to be randomized to the study. There are two cohorts- Part A (SAD) and Part B (MAD) cohorts. Total duration of study participation for each participant is up to approximately 36 days for Part A and up to approximately 50 days for Part B. In Part A and Part B, sequential cohorts will be exposed to increasing doses of M102 in order to identify an optimal therapeutic dose for future studies. M102 is an oral drug that may be able to reverse several disease pathways that cause Amyotrophic Lateral Sclerosis (ALS), a fatal, incurable disease of the nervous system. Testing the safety of taking the drug and the amount of drug in the body will help decide what dose to study in patients.

Competency in a range of movement skills (e.g. kicking, running, throwing) provides the foundation for an active lifestyle, however, very few children leave primary school having mastered foundational movement skills to support participation in a variety of physical activities. Our project will evaluate the feasibility of a time-efficient fundamental movement skill (FMS) program in primary schools.

Primary hyperparathyroidism is a common endocrine disease leading to considerable morbidity if untreated. Surgical resection of the overactive gland is the only curative treatment, with pre-operative localisation of the responsible gland(s) necessary to perform a minimally invasive surgical approach. The current standard of care in Australia is to undertake multimodal scans with neck ultrasound, [99mTc]Sestamibi SPECT/CT and four- dimensional computed tomography (4D CT). [18F]Fluorocholine (FCH) PET/CT is a novel imaging technique that is increasingly recognised as more accurate, with additional potential benefits including lower radiation exposure and shorter imaging time. This trial will compare the management impact of FCH PET/CT to conventional imaging. We hypothesise that FCH PET/CT will be as accurate as conventional imaging techniques while demonstrating lower radiation exposure, cost-effectiveness to the Australian health system and increased patient satisfaction.