ANZCTR search results

This study is to look at how safe and well tolerated PRX-101 is and to assess how much PRX-101 gets into the blood. PRX-101 is being developed as a possible treatment for paroxysmal supraventricular tachycardia which is a heart condition where the heart suddenly starts beating much faster than normal for a short period of time. The main hypothesis of this study is that PRX-101 is safe and well tolerated in a healthy adult population and that the pharmacokinetic profile (the amount that gets into the blood and how long it takes to be cleared from the body) is the same as that of an intravenous formulation of verapamil hydrochloride. A secondary hypothesis is that PRX-101 will have effects on blood pressure and heart rate.

Healthy and nutritious foods and meals can help to manage or improve diet-related conditions like type 2 diabetes (T2D), but access to healthy food can be challenging. FareShare is a large food relief organisation in Abbotsford, Melbourne, that cooks and freezes meals ready to be delivered to organisations to distribute to the community for free. FareShare and The George Institute for Global Health (TGI) are conducting the FareShare Medically Tailored Meals Pilot Program (or, FareShare MTM) with two community health organisations in Melbourne—cohealth and Holstep Health. You are invited to participate in this pilot study, which will test the feasibility of delivering ‘diabetes-friendly’ meals for free to individuals in the community to help improve diet and T2D. This information will help develop and expand future MTM programs for T2D in Australia. We aim to enrol 40 participants.

To determine if the new drug TT-20 is safe and well tolerated when given intravenously in different doses to healthy adults, either as a single dose or over 48 hours.

The aim of this study is to describe a sample of residential aged care facility (RACF) residents who died in hospital (in emergency, in the acute ward or in the palliative care unit) or at the RACF to quantify easily measurable components of quality end-of-life care. Specific objectives are as follows: 1. To understand the sociodemographic details of end-of-life care patients from residential aged care facilities, including diagnosis, age, sex, cultural and linguistically diverse background, and type of RACF placement. 2. To describe quality indicators of end-of-life care in patients from residential aged care facilities, such as the presence of an advanced care directive, congruence of place of death with preferences, and symptom management. 3. To understand the specialist palliative care and end-of-life care needs of patients from residential aged care facilities, including level of engagement with the various arms of the specialist palliative care service and use of end-of-life care medications. 4. To understand the factors associated with transfer from a residential aged care facility to hospital for end-of-life care. 5. To understand barriers to quality end-of-life care in residential aged care facilities.

Peripheral arterial disease management costs AUD $884 million per year. Post-operative duplex ultrasound surveillance is commonly used, despite limited evidence, based on theoretical benefits. International guidelines explicitly highlight this as a priority research area. This RCT is proposed to definitively evaluate whether ultrasound surveillance provides clinical benefits (preventing vessel occlusion, major adverse limb events or death) following femoropopliteal endovascular intervention compared to clinical surveillance alone. Both surveillance and peripheral arterial disease are costly, and the opportunity to identify cost-effectiveness is significant. This landmark study will provide urgently needed evidence to guide clinical practice, improve patient outcomes, and ensure cost-effective health-resource use.

This study is testing whether a fluoride treatment called Silver Diamine Fluoride (SDF) works better when it is followed by a short burst of light from a dental LED lamp. The treatment will be used on weakened (hypomineralised) molars in children that are planned for removal. We will assess whether using the light reduces sensitivity more than that without the light.

The study is testing a new drug called Tinodasertib to see if it is safe and well tolerated when taken by people who are overweight or obese. The drug is being looked at as a potential treatment to help with weight management. The study will take place at one location and include 64 participants, who will be randomly assigned to one of four groups. One group will get a placebo (a pill with no active drug), the other 3 groups will get either 10mg, 20mg or 30mg of Tinodasertib once a day. Everyone will take their assigned pill daily for 12 weeks, and all participants will also get advice on healthy eating and exercise throughout the study. Before starting the treatment, there is a 3-week screening period to check if people qualify. After the 12-week treatment there is a 3 week follow/up period to monitor participants health.

Health literacy is recognised by the WHO as “a critical determinant of health”. Poor health literacy is known to be associated with a wide range of adverse outcomes, including increased hospitalisation rates and emergency presentations, lower uptake of vaccinations, poor health, and higher risk of death among older people. We validated the HLS-Child-Q15 in English in our VITAL study (RGS5719, ACTRN12622001499774, manuscript in preparation). In the OSTRICH study we want to assess whether a child’s health literacy score as assessed by the HLS-Child-Q15 can predict outcomes after surgery. If outcomes can be predicted by a child’s health literacy score, then the routine assessment of health literacy may be useful in the perioperative management of children and to guide clinical practice when discharging children home after surgery.

This project aims to effectively and sustainably implement midline catheters across Australian paediatric settings and develop a toolkit that is scalable for national implementation. Our vision is to stop unnecessary PIVC pain, complications and reinsertion for children. Over a four-year period, this three-phase project will first co-design an implementation approach, then implement and evaluate it, and finally utilise the findings to develop a national toolkit for change. Phase 1 Co-design of implementation approach to adapt implementation and operational strategies locally, Phase 2 stepped wedge RCT of implementation across regional and tertiary paediatric hospital/wards (study included in this registration), Phase 3 will develop and disseminate a national toolkit for change.

To determine whether acetic acid chromoendoscopy improves the detection rate of sessile serrated lesions during screening colonoscopy in average-risk patients. This outcome is measured by the proportion of colonoscopies that detect histologically confirmed sessile serrated lesion (SSL-DR).