ANZCTR search results

This intervention is a novel and time-efficient program designed to enhance students' mental health and wellbeing. The intervention integrates school-based physical activity breaks with Cognitive Behavioural Therapy (CBT) techniques. Our project will evaluate the feasibility of this intervention among senior secondary school students.

This study aims to find out which simulation training method helps nurses perform better during a simulated resuscitation. It compares two approaches: Rapid Cycle Deliberate Practice (RCDP), which involves short, repeated practice with immediate feedback, and Traditional Immersive Simulation (TIS), which uses longer, more realistic scenarios and formal debriefing feedback. The main goal is to see which method results in better resuscitation performance such as faster delivery of defibrillation and higher quality chest compressions. We hypothesize that nurses trained with RCDP will perform this critical step more quickly than those trained with TIS.

This study aims to evaluate a novel mediated reality intervention for clinical use in those with knee osteoarthritis. Previous work has shown that mediated reality can be used to deliver body re-sizing illusions that reduce knee osteoarthritis symptoms. Recently we have worked with end-users to develop a clinic-ready version of this technology. The overarching aim of this project to test the clinic-ready version of this technology and evaluate its feasibility, acceptability, and preliminary efficacy in those with knee osteoarthritis.

The drug colchicine has been shown to be effective for cardiovascular disease prevention in the general population but is there is limited data available on colchicine in patients who are receiving haemodialysis for end-stage kidney disease. This project will aim to study the drug colchicine in patients who are receiving haemodialysis by examining for accumulation of colchicine, adverse effects of colchicine and effectiveness at colchicine at limiting inflammation markers. Three doses of colchicine will be used: 0.25mg three times weekly, 0.5mg three times weekly and 0.5mg daily. Participants will receive each dose of colchicine for 2 weeks sequentially. Findings from this study will provide a basis for larger clinical trials using colchicine in patients on haemodialysis.

Brief Summary: This study investigates the relationship between the immune microenvironment and Minimal Residual Disease (MRD) response in patients with amyloid light chain (AL) Amyloidosis treated with standard-of-care Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (D-VCD). It aims to improve MRD monitoring through novel flow cytometry and mass spectrometry techniques in peripheral blood, and to correlate these with bone marrow MRD assessed via EuroFlow. Aim: Unmet Need While most patients respond well to D-VCD, a subset experiences suboptimal outcomes. There is a need to identify these patients early and refine MRD detection methods to guide treatment decisions more effectively. Who is it for: Adults diagnosed with AL amyloidosis who are receiving first-line treatment with D-VCD, are eligible for MRD assessment and sample collection, and consented onto the Myeloma and Related Disease Registry (MRDR). Study Design: Prospective, observational correlative science study. Peripheral blood samples will be collected at baseline and at the start of the 6 treatment cycles, with bone marrow and blood collected post-induction and prior to maintenance therapy. MRD will be assessed using EuroFlow in bone marrow and novel flow cytometry and mass spectrometry in peripheral blood. It is hoped this study will: Identify immunological markers associated with MRD clearance. Improve MRD detection sensitivity and concordance between bone marrow and peripheral blood. Enable earlier identification of patients at risk of poor outcomes. Support MRD-guided treatment strategies in AL amyloidosis.

This pilot study is designed to evaluate a new co-designed mobile app that delivers cognitive behavioural therapy (CBT) for people with functional dyspepsia (FD), a common upper gastrointestinal disorder. The study will explore whether the app is easy to use, liked by patients, and if it helps to reduce symptoms and improve quality of life. Participants will be randomly assigned to one of three groups: 1) Mobile CBT App for 7 weeks, 2) Zoom CBT for 7 weeks, or 3) Waitlist Control (care as usual) for 7 weeks. Researchers will collect data on adherence to the app, how often participants use the app, and their feedback on using it. They will also measure changes in symptoms, quality of life, and mental health using questionnaires. Additionally, participants will undergo a baseline body surface gastric mapping test to explore if different stomach patterns affect how they respond to the CBT interventions.

The purpose of this study was to examine whether online training could improve Australian dietitians’ capability, opportunity, and motivation towards using specific behaviour change techniques, and their application of these techniques in their practice. Dietitians were randomly assigned to the intervention group, where they completed two interactive online workshops or to the control group who continued on with their usual practice. We expected that those who completed the training would show greater improvements in capability, opportunity, motivation, and the number of and frequency of behaviour change techniques compared with those in the control group.

Atrial fibrillation (AF) is the most common chronic heart rhythm problem and controlling risk factors are pivotal in management. Obstructive Sleep Apnoea (OSA) has emerged as an independent risk factor for AF and is defined by repetitive airway obstruction during sleep which overtime gives rise to AF. Conventional therapy is Continuous Positive Airway Pressure (CPAP) which is worn during sleep to prevent airway collapse. However, CPAP therapy is not all tolerated and Mandibular advancement splints (MAS) device has emerged as alternative therapy to CPAP. Customized MAS is worn during sleep which repositions the jaw anteriorly to keep airway patent. This study aims to evaluate the impact of patient centred approach in management of OSA on AF burden.

This research project will test a new technology called the "Smart Footprint System" and aims to help people, with diabetes, to understand if they have differing foot temperatures to help with foot care. People with diabetes are at high risk of foot wounds, called ulcerations. This new technology can check foot temperature by standing on a mat called the "Smart Footprint" and then sending this information to an App, the "Smart Footprint" App. The mat measures skin temperature on both feet to see if there is a temperature difference between the two feet. If there is, it could mean an ulcer is forming. The aim of this research is to understand if people are willing and able to use the "Smart Footprint System" in their home and also, what worked well and what was challenging when using the system. Research participants need to be 18 or older with either type 1 or type 2 diabetes and with a diagnosis of peripheral neuropathy. For this study 12 participants will be recruited and these will come from two sites, one metro and one regional. This project will measure data from the system but also collect interview data from individuals. It is hoped that this project can show if this system works for people using it in their own home.

In response to growing concerns about the effects of social media on young people’s health and wellbeing, the Australian Government has announced plans to restrict access to social media platforms for children and adolescents aged under 16 years of age, to be enforced through age verification systems. This study aims to assess the potential impact of the national social media age restrictions on adolescent social media use and wellbeing outcomes. This study will collect self-reported data from parent-adolescent dyads (aged 12-17 years) via three surveys conducted before and after (3- and 12-months) the social media age restrictions are implemented. Measures will assess changes to adolescent mental health, sleep quality, physical activity, nutrition, and patterns of social media use prior to, and after, the age restrictions are implemented. The findings will provide timely evidence to inform public health and digital policy and contribute to the limited literature on large-scale social media regulation.